Neuroprotective measures in children with traumatic brain injury

查看全文 作　　者：Shruti [1]Agrawal;Ricardo Garcia [1]Branco

机构地区：[1]Department of Paediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust

出　　处：《World Journal of Critical Care Medicine》索引2016年第5卷第1期,共11页

摘　　要：Traumatic brain injury(TBI) is a major cause of death and disability in children. Severe TBI is a leading cause of death and often leads to life changing disabilities in survivors. The modern management of severe TBI in children on intensivecare unit focuses on preventing secondary brain injury to improve outcome. Standard neuroprotective measures are based on management of intracranial pressure(ICP) and cerebral perfusion pressure(CPP) to optimize the cerebral blood flow and oxygenation, with the intention to avoid and minimise secondary brain injury. In this article, we review the current trends in management of severe TBI in children, detailing the general and specific measures followed to achieve the desired ICP and CPP goals. We discuss the often limited evidence for these therapeutic interventions in children, extrapolation of data from adults, and current recommendation from paediatric guidelines. We also review the recent advances in understanding the intracranial physiology and neuroprotective therapies, the current research focus on advanced and multi-modal neuromonitoring, and potential new therapeutic and prognostic targets. 关键词：PAEDIATRICS INTRACRANIAL pressure TRAUMATIC brain injury Neuroprotection PAEDIATRIC critical care Advanced NEUROMONITORING

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Neuroprotective measures in children with traumatic brain injury

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