Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system:more than just receptor cooperation?

查看全文 作　　者：Darius [1]Widera;Rocío Martínez [1,2]Aguilar;Graeme [3]S.Cottrell

机构地区：[1]Stem Cell Biology and Regenerative Medicine Group,School of Pharmacy,University of Reading,Whiteknights campus;[2]Unidad de Inmunología,IBIMER,Universidad de Granada;[3]Cellular and Molecular Neuroscience,School of Pharmacy,University of Reading

出　　处：《Neural Regeneration Research》索引2019年第14卷第7期,共6页

摘　　要：Toll-like receptor 4(TLR4) and protease-activated receptor 2(PAR2) play pivotal roles in the mammalian innate immune response.Notably,in addition to their involvement in detection of invading pathogens,PAR2 and TLR4 modulate the levels of cell death-induced sterile inflammation by activating pro-or anti-inflammatory downstream signaling cascades.Within the central nervous system,there is emerging evidence that both receptors are involved in synaptic transmission and brain plasticity.Furthermore,due to their prominent role in mediating neuroinflammation,PAR2 and TLR4 are associated with development and progression of neurodegenerative disorders including but not limited to Alzheimer's disease,Parkinson's disease and multiple sclerosis.In this article,we summarise the current knowledge on the cooperation between PAR2 and TLR4,discuss the potential cross-talk levels and highlight the impact of the cross-coupling on neuroinflammation. 关键词：signaling inflammation proteases MYELOID of differentiation primary response gene 88 TIR-domain containing ADAPTOR inducing INTERFERON lipopolysaccharide TLR4 PAR2

相关文献

参考文献（44）
引证文献（3）
耦合文献（0）

参考文献(44)

引证文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system:more than just receptor cooperation?

参考文献(44)

引证文献(3)

用户提示