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Preparation and Pharmacodynamic Evaluation of Kang Zhu Gan Lu Oral Proliposome, a New Hypoglycemic Tibetan Medicine

查看全文 作　　者：Weini [1]DAI;Yu [1]MAO;Lingmin [1]LIN;Xinran [1]MI 高影响力作者 机构地区：[1]College of Pharmacy, Southwest Minzu University高影响力机构 出　　处：《Medicinal Plant》索引2019年第10卷第5期,共5页高影响力期刊 基　　金：Supported by Integration and industrialization demonstration of comprehensive utilization and development of the unique ecological Malus torangoades(Rehd.)Hughes in the Qinghai-Tibet Plateau(Guo Ke Fa Nong[2012]745) 摘　　要：[Objectives]To effectively solve the problem of poor oral bioavailability of total flavonoids in Kang Zhu Gan Lu(ZYZH),a new hypoglycemic Tibetan solid preparation,ZYZH oral proliposome was prepared by modern preparation method,and its hypoglycemic effect was evaluated.[Methods]ZYZH proliposome was prepared by carrier deposition method,and its particle morphology and Zeta potential were detected.Taking encapsulation efficacy as indictor,the optimal prescription and preparation process of ZYZH oral proliposome were screened by orthogonal experiment.In addition,the hypoglycemic activity of ZYZH oral liposome in alloxan-induced hyperglycemic mice was studied.[Results]The repose angle,average particle size,encapsulation efficiency,and Zeta potential of ZYZH proliposome are 34.2°,(442.5±3.5)nm,67.7%and(-47.2±3.4)mV,respectively.Compared with the model group,the fasting blood glucose level of the hyperglycemic mice significantly declined(P<0.01),and their body weight changed insignificantly after four weeks of oral administration of ZYZH proliposome(P>0.05).[Conclusions]The preparation process of ZYZH oral proliposome is characterized by simple operation,high encapsulation efficiency and good stability.The new hypoglycemic Tibetan drug ZYZH oral liposome has obvious hypoglycemic effect on alloxan-induced hyperglycemic mice. 关 键 词：Proliposome ENCAPSULATION efficiency TIBETAN medicine Diabetes
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