Mitochondria-localized iridium(Ⅲ) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia

查看全文 作　　者：Song [1]Guo;Meiping [1]Han;Ruizhe [1]Chen;Yanling [1]Zhuang;Liang [1]Zou;Shujuan [1]Liu;Wei [1,2]Huang;Qiang [1]Zhao

机构地区：[1]Key Laboratory for Organic Electronics&Information Displays,Institute of Advanced Materials,Nanjing University of Posts&Telecommunications,Nanjing 210023,China;[2]Shaanxi Institute of Flexible Electronics,Northwestern Polytechnical University,Xi'an 710072,China

出　　处：《Science China Chemistry》索引2019年第62卷第12期,共10页

基　　金：supported by the National Funds for Distinguished Young Scientists (61825503);the National Program for Support of Top-Notch Young Professionals;the Priority Academic Program Development of Jiangsu Higher Education Institutions (YX03001);China Postdoctoral Science Foundation Funded Project (2018M642282);Natural Science Foundation of Jiangsu Province of China (BK20180760);Jiangsu Planned Projects for Postdoctoral Research Funds (2018K155C) 摘　　要：Photodynamic therapy(PDT)is a potential way for the tumor treatment.However,it notably suffers the limitation of hypoxia in solid tumors.Thus,it is significant to develop effective photosensitizers which can exhibit excellent therapeutic performance under both normoxia and hypoxia.Herein,we reported four ionic iridium(Ⅲ)complexes(Irl-Ir4)with anthraquinone groups which can regulate their excited state energy levels effectively.Among them,the energy gap of Ir1 was between 1.63 and 2.21 eV,which can match well with that of O2,and the HOMO energy of Ir1 is less than-5.51 eV.Compared with Ir2-Ir4,the luminescent quantum efficiency of Irl was the highest.Particularly,Ir1 can specifically target the mitochondria of the tumor cells.Meanwhile,Ir1 showed high singlet oxygen quantum yields(Ф△)in both solutions and living cells with low cytotoxicity.The results of PDT experiments revealed that Irl,as a photosensitizer,exhibited excellent therapeutic effect not only in normoxia but also in hypoxia condition.We believe that this work is meaningful for developing excellent PDT agents based on cyclometalated Ir(III)complexes via rational ligand modification. 关键词：photodynamic therapy iridium(Ⅲ)complexes anthraquinone groups PHOTOSENSITIZERS singlet oxygen

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Mitochondria-localized iridium(Ⅲ) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia

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