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Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

查看全文 作　　者：Lisha [1]Zhu;Dan [2]Luo;Yan [1]Liu 高影响力作者 机构地区：[1]Laboratory of Biomimetic Nanomaterials,Department of Orthodontics,Peking University School and Hospital of Stomatology,National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing Key Laboratory of Digital Stomatology,Beijing,China;[2]State Key Laboratory of Heavy Oil Processing,College of New Energy and Materials,Beijing Key Laboratory of Biogas Upgrading Utilization,China University of Petroleum(Beijing),Beijing,China高影响力机构 出　　处：《International Journal of Oral Science》索引2020年第12卷第1期,共15页高影响力期刊 基　　金：The authors acknowledge the financial support from the Beijing Municipal Natural Science Foundation No.2184119(D.L.)and No.L182005(Y.L.);the Projects of Beijing Nova Programme No.Z171100001117018(Y.L.);Beijing Nova Programme Interdisciplinary Cooperation Project No.Z181100006218135(Y.L.and D.L.);the National Natural Science Foundations of China No.81571815(Y.L.),No.81871492(Y.L.)and No.51902344(D.L.);the Science Foundation of China University of Petroleum No.2462018BJB002(D.L.). 摘　　要：Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage.However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering(TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration. 关 键 词：STRUCTURE STORES protective
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