Binding to m6A RNA promotes YTHDF2-mediated phase separation

查看全文 作　　者：Jiahua [1]Wang;Liyong [1]Wang;Jianbo [1,3]Diao;Yujiang Geno [5]Shi;Yang [2,3]Shi;Honghui [4]Ma;Hongjie [1]Shen

机构地区：[1]Center for Medical Research and Innovation,Shanghai Pudong Hospital,Fudan University Pudong Medical Center and Institutes of Biomedical Sciences,Fudan University,Shanghai 201399,China;[2]Division of Newborn Medicine and Epigenetics Program,Department of Medicine,Boston Children's Hospital,Boston,MA 02115,USA;[3]Cell Biology Department,Harvard Medical School,Boston,MA 02115,USA;[4]Key Laboratory of Arrhythmias of the Ministry of Education of China,East Hospital,Tongji University School of Medicine,Shanghai 200120,China;[5]Division of Endocrinology,Diabetes and Hypertension,Department of Medicine,Brigham and Women's Hospital,Harvard Medical School,Boston,MA,USA

出　　处：《Protein & Cell》索引2020年第11卷第4期,共4页

摘　　要：Dear Editor,As one of the most abundant modifications on mRNA in mammal,A^6-methyladenosine(m6A)has been demonstrated to play important roles in various biological processes including nuclear RNA export,mRNA splicing,miRNA processing,mRNA degradation and translation(Shi et al.,2019).Importantly,different m6A reader proteins have been shown to play central roles in these processes. 关键词：al. processes. m6A

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Binding to m6A RNA promotes YTHDF2-mediated phase separation

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