Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis:An opinion review

查看全文 作　　者：Paul [1]Brennan;Kathleen [2]Clare;Jacob [1]George;John F [1]Dillon

机构地区：[1]Department of Molecular and Clinical Medicine,University of Dundee,Ninewells Hospital and Medical School,Dundee DD19SY,United Kingdom;[2]Department of Neurology,Queen Elizabeth Hospital,Glasgow G514TF,United Kingdom

出　　处：《World Journal of Gastroenterology》索引2020年第26卷第15期,共8页

摘　　要：There has long been a recognised association between non-alcoholic fatty liver disease(NAFLD)and the composite aspects of the metabolic syndrome.Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD.There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD.Given the increased economic and health burden associated with the NAFLD epidemic,improved methods of population-based,minimally-invasive methods and biomarkers are clearly highly sought and necessary.In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process. 关键词：Non-alcoholic FATTY LIVER disease Non-alcoholic steatohepatitis Uric acid URATE Non-invasive fibrosis markers FATTY LIVER index

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Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis:An opinion review

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