A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging

查看全文 作　　者：Jiacheng [1,3]Lin;Qianqian [1]Li;Xiaodong [1]Zeng;Ziyang [1]Chen;Qihang [1]Ding;Yang [1]Li;Hui [1]Zhou;Xianli [2]Meng;Deliang [4]Chen;Zixin [1]Deng;Xuechuan [1]Hong;Yuling [1]Xiao

机构地区：[1]State Key Laboratory of Virology,Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE),School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071,China;[2]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Sichuan 611137,China;[3]Department of Chemistry,University of Cambridge,Cambridge CB21EW,UK;[4]Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry,Chemistry and Chemical Engineering College,Gannan Normal University,Jiangxi 341000,China

出　　处：《Science China Chemistry》索引2020年第63卷第6期,共5页

基　　金：supported by the National Natural Science Foundation of China(81773674,21473041,81573383);Natural Science Foundation of Hubei Province(2017CFB711,2017CFA024,2016ACA126);the Fundamental Research Funds for the Central Universities,Tibet Autonomous Region Science and Technology Plan Project Key Project(XZ201901-GB-11);the Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology(2019020701011429);Project First-Class Disciplines Development Supported by Chengdu University of Traditional Chinese Medicine(CZYJC1903);Health Commission of Hubei Province Scientific Research Project(WJ2019M178,WJ2019M177)。 摘　　要：Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model. 关键词：NIR-II orthotopic osteosarcoma IMAGING

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A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging

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