α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome

查看全文 作　　者：Rui [1]Wang;Hongyang [1]Sun;Haigang [1]Ren;Guanghui [1]Wang

机构地区：[1]Laboratory of Molecular Neuropathology,Jiangsu Key Laboratory of Neuropsychiatric Diseases&Department of Pharmacology,College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China

出　　处：《Science China(Life Sciences)》索引2020年第63卷第12期,共10页

基　　金：supported by the National Natural Science Foundation of China(31871023,31970966);the National Key Scientific Research and Development Program of China(2016YFC1306000);Suzhou Clinical Research Center of Neurological Disease(Szzx201503);the Priority Academic Program Development of Jiangsu Higher Education Institutions。 摘　　要：The presence of intraneuronal Lewy bodies(LBs) and Lewy neurites(LNs) in the substantia nigra(SN) composed of aggregatedα-synuclein(α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease(PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity. The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology. 关键词：Α-SYNUCLEIN Lewy pathology MITOCHONDRIA LYSOSOME AGGREGATION transmission

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α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome

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