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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | 基于LACP协议的链路聚合状态机模块的实现显示文摘首先介绍了链路聚合技术的背景和基本概念,接着说明了LACP协议(Link Aggregation Control Protocol)的内容和原理,其中LACP状态机模块控制着整个LACP协议的运转,是保证基于LACP协议的链路聚合可以有效工作的核心和关键模块。最后以802.3ad的LACP协议为基础,利用有限状态机的设计方法,实现并优化了LACP协议状态机模块的功能。经测试,该模块功能运行正常,能够正确处理协议运行的各种情况。 | 郑涛 郭裕顺 | 2010 | 计算机系统应用2010，19，5： | 17 |
| 3 | A multi-step approach for block-cave production scheduling optimization显示文摘Production schedules that provide optimal operating strategies while meeting practical,technical,and environmental constraints are an inseparable part of mining operations.Relying only on manual planning methods or computer software based on heuristic algorithms will lead to mine schedules that are not the optimal global solution.Mathematical mine planning models have been proved to be very effective in supporting decisions on sequencing the extraction of material in mines.The objective of this paper is to develop a practical optimization framework for caving operations’production scheduling.To overcome the size problem of mathematical programming models and to generate a robust practical near-optimal schedule,a multi-step method for long-term production scheduling of block caving is presented.A mixed-integer linear programming(MILP)formulation is used for each step.The formulations are developed,implemented,and verifed in the TOMLAB/CPLEX environment.The production scheduler aims to maximize the net present value of the mining operation while the mine planner has control over defned constraints.Application and comparison of the models for production scheduling using 298 drawpoints over 15 periods are presented. | Yashar Pourrahimian Hooman Askari-Nasab Dwayne D.Tannant | 2013 | International Journal of Mining Science and Technology2013，23，5： | 13 |
| 4 | Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease显示文摘Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral abnormalities.The poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s disease.The occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of neurodegeneration.Recently,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional perturbations.Despite mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both pathologies.Thus,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been proposed.Among others,the immune system seems to be strongly involved in amyloid-beta and tau pathologies.Other factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau hyperphosphorylation.Interestingly,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical trials.Likewise,it has been shown that tau-immunotherapy also reduces amyloid-beta levels.Thus,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapies at early stages of the disease have recently been proposed as a strategy to stop the progression of Alzheimer’s disease. | Alejandro R.Roda Gabriel Serra-Mir Laia Montoliu-Gaya Lidia Tiessler Sandra Villegas | 2022 | Neural Regeneration Research2022，17，8： | 13 |
| 5 | Feature-Based Aggregation and Deep Reinforcement Learning:A Survey and Some New Implementations显示文摘In this paper we discuss policy iteration methods for approximate solution of a finite-state discounted Markov decision problem, with a focus on feature-based aggregation methods and their connection with deep reinforcement learning schemes. We introduce features of the states of the original problem, and we formulate a smaller 'aggregate' Markov decision problem, whose states relate to the features. We discuss properties and possible implementations of this type of aggregation, including a new approach to approximate policy iteration. In this approach the policy improvement operation combines feature-based aggregation with feature construction using deep neural networks or other calculations. We argue that the cost function of a policy may be approximated much more accurately by the nonlinear function of the features provided by aggregation, than by the linear function of the features provided by neural networkbased reinforcement learning, thereby potentially leading to more effective policy improvement. | Dimitri P.Bertsekas | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 12 |
| 6 | Frequency control of future power systems: reviewing and evaluating challenges and new control methods显示文摘Integration of more renewable energy resources introduces a challenge in frequency control of future power systems.This paper reviews and evaluates the possible challenges and the new control methods of frequency in future power systems.Different types of loads and distributed energy resources(DERs) are reviewed.A model representation of a population of the water heater devices for the demand side frequency response is considered.A model representation of a population of battery energy storage system(BESS)-based DERs such as smart electric vehicles(EVs) charging, large-scale BESSs, and residential and non-residential BESSs, are highlighted.The simplified Great Britain power system and the 14-machine South-East Australian power system were used to demonstrate the effectiveness of the new methods in controlling power system frequency following a disturbance.These new methods are effective in recovering the fallen frequency response and present a great potential in controlling the frequency in future power systems. | Zeyad Assi OBAID Liana M.CIPCIGAN Lahieb ABRAHIM Mazin T.MUHSSIN | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 8 |
| 7 | Cuproptosis:a new v form of programmed cell death显示文摘A recent study by Tsvetkov et al.was published in Science and proposed a novel form of copper-induced cell death.Tsvetkov et al.revealed that excess intracellular copper induces the aggregation of lipoylated dihydrolipoamide S-acetyltransferase(DLAT),which is associated with the mitochondrial tricarboxylic acid(TCA)cycle,resulting in proteotoxic stress and leading to a novel form of cell death termed cuproptosis[1]. | Yongqiang Wang Long Zhang Fangfang Zhou | 2022 | Cellular & Molecular Immunology2022，19，8： | 8 |
| 8 | Effect of Liangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome显示文摘Objective:To investigate the effects of Uangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome induced by mutifactor stimuli.Methods:SD rats were divided into control, model,Uangxuehuayu Recipe(high,middle and low dose,18,9,4.S g/kg accordingly).Except the control group,blood stasis model was established in the rest groups.The hemorheological parameters were measured and compared.Results:Blood viscosity at high,moderate and low level in rats with blood stasis significantly increased(P<0.05),but blood viscosity at high level and plasma viscosity was significantly decreased in rats induced by some stimuli after Uangxuehuayu Recipe were intra-gastrically administered for I weeks(P<0.01,P<0.05). Conclusions:Uangxuehuayu Recipe is effective in improving hemorheology,and has important application value in the prevention of occurrence and development of ischemic stroke. | Song-Yi Ning Biao-Ping Jiang Li Xu Tai-Hui Fang Mian-Hua Wu | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 7 |
| 9 | Asphaltenes: Separations, structural analysis and applications显示文摘Asphaltenes, complex aromatic compounds from various carbonaceous sources, could be obtained by solvent dissolution, filtration and adsorption. It was difficult to clarify the molecular structures and chemical properties of asphaltene due to its structural similarity, composition complexity and source dependences. Many techniques, like Mass spectrometry, Chromatography, Nuclear magnetic resonance spectroscopy, Infrared spectroscopy, Roman spectroscopy, Fluorescence spectroscopy, X-ray diffraction analysis and Small-angle scattering techniques and so on, have revealed some valuable descriptions of asphaltenes chemical compositions and fundamental structures. Moreover, advanced Mass spectrometry,Atomic force microscopy and Scanning tunneling microscopy could provide more clear and essential molecular compounds and structures in asphaltenes. In addition, several asphaltenes models have succeeded to illustrate aggregation properties asphaltene. In this work, the progress on asphaltene separation, characterization and application was summarized, and the similarities and differences between coal-derived asphaltenes and petroleum asphaltenes were compared. Furthermore, the reactivity of asphaltenes has been discussed in the aspect of hydroprocessing, pyrolysis and gasification. Asphaltene was excellent carbon precursor for functional carbon material due to its high aromaticity and carbon yield;several porous carbon nanosheets from asphaltenes that would be prospective electrode materials after being graphitized were shown. Pitch-based carbon fiber derived from coal-derived asphaltenes displayed a tensile strength of 1.0 GPa and elastic modulus of 350 MPa, respectively. These powerful advances will provide asphaltenes promising developments. | Pingping Zuo Shijie Qu Wenzhong Shen | 2019 | Journal of Energy Chemistry2019，28，7： | 7 |
| 10 | Host compatibility interacts with seed dispersal to determine smallscale distribution of a mistletoe in Xishuangbanna,Southwest China显示文摘Aims Mistletoe infection between intra- and interspecific hosts can be restricted by seed dispersal, host–mistletoe compatibility and other factors, yet few studies have linked seed dispersal and seedling establishment together for understanding mistletoe plant distribution and demography together in different anthropogenic disturbance forest types at a local scale. The objectives of this study were to examine how three factors—seed disperser behavior, post-dispersal host compatibility and canopy cover—affect the spatial distribution of a generalist mistletoe Dendrophthoe pentandra (Loranthaceae) in plantation and rainforest within Xishuangbanna, Southwest China.MethodsWe observed mistletoe D. pentandra infection patterns at the scale of individual trees and sixteen 400-m2 forest plots in adjacent plantation and rainforest within Xishuangbanna. To elucidate what determines infection patterns at different scales and in different forest types, we observed the behavior of major avian seed dispersers and carried out a seed inoculation experiment to examine how post-dispersal compatibility and light incidence affect the infection of different hosts.Important FindingsDendrophthoe pentandra displayed an aggregated distribution and infected 10 species in our study site, with a significantly higher infection prevalence and intensity in the plantation than in the tropical forest. Different seed dispersers provided contrasting initial mistletoe templates: the specialist frugivore Dicaeum concolor (plain flowerpecker) preferred to fly between mistletoes in infected trees in the plantation and likely intensified existing infections. In contrast, the dietary generalist Pycnonotus jocosus(red-whiskered bulbul) was more likely to visit uninfected trees, thereby establishing new infections. Thus, seed dispersal appears to be an important determinant of the mistletoes distribution, with deposition patterns providing an initial distribution template and determining small-scale patterns. However, post-dispersal and abiotic factors revealed that different host compatibilities and levels of light incidence in different habitats affected the survival of D. pentandra seedlings. Hence, our findings suggest that seed dispersal interacts with host compatibility and canopy cover to determine establishment success, survival and the observed distribution patterns. | Yahuang Luo Yi Sui Jianmin Gan Ling Zhang | 2016 | Journal of Plant Ecology2016，9，1： | 6 |
| 11 | Dispersion stability of thermal nanofluids显示文摘Thermal nanofluids, the engineered fluids with dispersed functional nanoparticles, have exhibited extraordinary thermophysical properties and added functionalities, and thus have enabled a broad range of important applications. The poor dispersion stability of thermal nanofluids, however, has been considered as a longexisting issue that limits their further development and practical application. This review overviews the recent efforts and progresses in improving the dispersion stability of thermal nanofluids such as mechanistic understanding of dispersion behavior of nanofluids, examples of both water-based and oil-based nanofluids,strategies to stabilize nanofluids, and characterization techniques for dispersion behavior of nanofluids. Finally,on-going research needs, and possible solutions to research challenges and future research directions in exploring stably dispersed thermal nanofluids are discussed. | Fan Yu Yingying Chen Xingbo Liang Jiale Xu Chiahsun Lee Qi Liang Peng Tao Tao Deng | 2017 | Progress in Natural Science:Materials International2017，27，5： | 5 |
| 12 | Cuproptosis:lipoylated TCA cycle proteins-mediated novel cell death pathway显示文摘In a recent study published in Science,Tsvetkov et al1.shed a light on a new form of cell death,copper-dependent cell death(termed cuproptosis).They defined“cuproptosis”as a nonapoptotic cell death pathway.They have demonstrated that copper directly binds to lipoylated components of the tricarboxylic acid(TCA)cycle.Then aggregation of these copper-bound,lipoylated mitochondrial proteins and subsequent Fe-S cluster protein loss triggered proteotoxic stress and a distinct form of cell death. | Su-Ran Li Lin-Lin Bu Lulu Cai | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 5 |
| 13 | Development of aggregated state chemistry accelerated by aggregation-induced emission显示文摘Light is an essential ingredient of human civilization, and has been tightly associated with society and everyone’s daily life. Light can be emitted from various kinds of luminophores, and the concept of aggregation-induced emission(AIE)was a breakthrough in the field of organic light-emitting materials, which experienced stages of pursuing truth, discarding prejudices and creating new knowledge. | Yujun Xie Zhen Li | 2021 | National Science Review2021，8，6： | 5 |
| 14 | 血小板聚集功能生物参考区间验证显示文摘目的对血小板聚集仪CHRONO-LOG CA 560的生物参考区间进行验证,以保证其适用于临床。方法按美国临床实验室标准化委员会NCCLS C28-A2推荐的方法,验证项目选择健康参考个体20例,用仪器CHRONO-LOGCA 560血小板聚集仪进行检测。结果 20例健康个体数据中,以胶原作为聚集剂95%结果符合厂家提供的生物参考区间,而另外两个聚集剂二磷酸酰苷(ADP)和肾上腺素的结果则100%符合该生物参考区间。结论原厂家提供的生物区间适用于广东省地区人群,可供使用。实验验证简单易行,容易发现生物参考区间的偏离,值得建立完善的验证制度和程序,并推广应用。 | 马建宏 李广华 周东铭 梁玲 黄美群 欧阳维富 黄锦维 贾雪 | 2010 | 血栓与止血学2010，16，6： | 4 |
| 15 | Studies on bio-antioxidants——Ⅱ.An ESR study on the antioxidant efficiency of ascorbyl palmitate in micelles显示文摘The kinetics for the reaction of ascorbyl palmitate and 4-hydroxy-TEMPO,4-methoxy-TEMPO or 4-hexanoyloxy-TEMPO in CTAB and SDS micelles was studied by ESR spectroscopy.It was found that the behavior of ascorbyl palmitate is remarkably different from ascorbic acid in theirantioxidant activity in micelles.The predominant factors governing the activity in micelles involvethe lipophilicity of the antioxidant and the oxidant,the charge type of the substrates and the concentra-tion of the surfactant.As high as 2×10~4 fold rate variation was observed by changing the lipophilicityof the antioxidant and the microenvironment of the reaction medium. | LIU,Zhong-Li HAN,Zheng-Xu CHENG,Pin WU,Lung-Min LIU,You-Cheng National Laboratory on Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou,730000 | 1991 | Chinese Journal of Chemistry1991，9，2： | 4 |
| 16 | Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease:two triggers, one disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder that affects millions worldwide.Due to population ageing,the incidence of AD is increasing.AD patients develop cognitive decline and dementia,features for which is known,requiring permanent care.This poses a major socio-economic burden on healthcare systems as AD patients’relatives and healthcare workers are forced to cope with rising numbers of affected people.Despite recent advances,AD pathological mechanisms are not fully understood.Nevertheless,it is clear that the amyloid beta(Aβ)peptide,which forms amyloid plaques in AD patients’brains,plays a key role.Type 2 diabetes,the most common form of diabetes,affects hundreds of million people globally.Islet amyloid polypeptide(IAPP)is a hormone coproduced and secreted with insulin in pancreatic β-cells,with a key role in diabetes,as it helps regulate glucose levels and control adiposity and satiation.Similarly to Aβ,IAPP is very amyloidogenic,generating intracellular amyloid deposits that causeβ-cell dysfunction and death.It is now clear that IAPP can also have a pathological role in AD,decreasing cognitive function.IAPP harms the blood-brain barrier,directly interacts and co-deposits with Aβ,promoting diabetes-associated dementia.IAPP can cause a metabolic dysfunction in the brain,leading to other diabetes-related forms of AD.Thus,here we discuss IAPP association with diabetes,Aβand dementia,in the context of what we designate a“diabetes brain phenotype”AD hypothesis.Such approach helps to set a conceptual framework for future IAPP-based drugs against AD. | Sofia Ferreira Ana F.Raimundo Regina Menezes Ivo C.Martins | 2021 | Neural Regeneration Research2021，16，6： | 4 |
| 17 | Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT显示文摘We aimed to measure platelet function and its relationship with β2-GPI in prolonged isolated thrombocytopenia(PT) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Fifty-six patients with PT and 60 allo-HSCT recipients without PT(non-PT controls) were enrolled.Platelet aggregation and activation,β2-GPI and anti-β2-GPI antibody levels,vWF antigen,and vWF activity were analyzed.The effect of β2-GPI on platelet aggregation was also measured ex vivo.Results showed that ADP-induced platelet aggregation significantly increased(39%±7.5% vs.23%±8.5%,P=0.032),and the platelet expression of both CD62 p(33.6%±11.6% vs.8.5%±3.5%,P<0.001) and PAC-1(42.4%±7.6% vs.6.8%±2.2%,P<0.001) was significantly higher in patients with PT than in those without PT.Significantly lower β2-GPI levels(164.2±12 μg m L^-1 vs.234.2±16 μg mL^-1,P<0.001),higher anti-β2-GPI IgG levels(1.78±0.46 U mL^-1 vs.0.94±0.39 U mL^-1,P<0.001),and increased vWF activity(133.06%±30.50% vs.102.17%±25.90%,P<0.001) were observed in patients with PT than in those without PT.Both ADPinduced platelet aggregation(n=116,r^2=-0.5042,P<0.001) and vWF activity(n=116,r^2=-0.2872,P<0.001) were negatively correlated with β2-GPI levels.In summary,our data suggested that platelet aggregation and activation were significantly higher in patients with PT than in those without PT,which might be associated with reduced β2-GPI levels.The reduced β2-GPI levels might be due to the existence of anti-β2-GPI IgG. | Haixia Fu Jingzhong Zhao Lanping Xu Kaiyan Liu Yu Wang Huan Chen Wei Han Jingzhi Wang Fengrong Wang Xiaojun Huang Xiaohui Zhang | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 18 | Simulation of micro-behaviors including nucleation,growth,and aggregation in particle system显示文摘A new method for the solution of population balance equations(PBE) describing the micro-processes such as nucleation,growth,aggregation of particle swarms in a multiphase system is proposed.The method is based on the fixed pivot moment and allows arbitrary number of moments to be tracked si-multaneously.By expressing PBEs for both batch and continuous operations in a general form,and using weighted residual method to derive the moment equations,different moments can be tracked directly.The numerical density function is assumed to be a summation of several weighted Dirac Delta functions,and the integral and derivative terms in PBEs are transformed to a summation in order to reduce computational cost.Simulations of a batch nucleation-growth process and a continuous ag-gregation-growth process have demonstrated good agreement with the corresponding analytical solu-tions,with relative errors less than 108%.Simulation of a combined nucleation-growth-aggregation process,which does not have an analytical solution,is also included,so as to reproduce the mi-cro-behaviors of such a complex system,demonstrating the feasibility and reliability of this method. | GU ZhaoLin SU JunWei JIAO JianYing XU X Yun | 2009 | Science China Chemistry2009，52，2： | 4 |
| 19 | α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome显示文摘The presence of intraneuronal Lewy bodies(LBs) and Lewy neurites(LNs) in the substantia nigra(SN) composed of aggregatedα-synuclein(α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease(PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity. The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology. | Rui Wang Hongyang Sun Haigang Ren Guanghui Wang | 2020 | Science China(Life Sciences)2020，63，12： | 4 |
| 20 | Approximation for a scheduling problem with application in wireless networks显示文摘A network of many sensors and a base station that are deployed over a region is considered.Each sensor has a transmission range,an interference range and a carrier sensing range,which are r,αr and βr,respectively.In this paper,we study the minimum latency conflict-aware many-to-one data aggregation scheduling problem:Given locations of sensors along with a base station,a subset of all sensors,and parameters r,α and β,to find a schedule in which the data of each sensor in the subset can be transmitted to the base station with no conflicts,such that the latency is minimized.We designe an algorithm based on maximal independent sets,which has a latency bound of(a+19b)R + Δb-a + 5 time slots,where a and b are two constant integers relying on α and β,Δ is the maximum degree of network topology,and R is the trivial lower bound of latency.Here Δ contributes to an additive factor instead of a multiplicative one,thus our algorithm is nearly a constant(a+19b)-ratio. | ZHU QingHua & LI DeYing Key Laboratory of Data Engineering and Knowledge Engineering,MOE,School of Information,Renmin University of China,Beijing 100872,China | 2010 | Science China Mathematics2010，53，6： | 4 |
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