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Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(Ⅱ)metallacycle-loaded biomimic melanin dots

查看全文 作　　者：Chonglu [1]Li;Pei-Pei [2]Jia;Yu-Ling [1]Xu;Feng [1]Ding;Wen-Chao [1]Yang;Yao [1]Sun;Xiao-Peng [3]Li;Guang-Qiang [3]Yin;Lin [2]Xu;Guang-Fu [1]Yang 高影响力作者 机构地区：[1]Key Laboratory of Pesticide&Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079,China;[2]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering,East China Normal University.Shanghai 200062,China;[3]Department of Chemistry,University of South Florida,Tampa 33620,USA高影响力机构 出　　处：《Science China Chemistry》索引2021年第64卷第1期,共9页高影响力期刊 基　　金：the National Key Research and Development Program(2017YFA0505203);the National Natural Science Foundation of China(21672070);the Fundamental Research Funds for the Central Universities;the Opening Projects of Shanghai Key Laboratory of Green Chemistry and Chemical Processes。 摘　　要：Pt(Ⅱ)-based metallacycles,as an important family of supramolecular coordination complexes(SCCs),have exhibited excellent antitumor activity at the cell level.However,the biomedical applications of Pt(Ⅱ)-based metallacycles for animal studies are still hindered by their poor stability,non-targeted tumour,and lack of detectable feedback for evaluating therapeutic progress.Herein,we propose a strategy that introduces melanin dots as a biomedical platform to load bright-emission Pt(Ⅱ)-based metallacycles,thereby constructing a theranostic agent that enables photoacoustic imaging(PAI)-guided chemo-photothermal combinational therapy.Melanin dots act as a protective carrier to preserve the integrity of Pt(Ⅱ)-based metallacycles before uptake by tumour tissues.Meanwhile,the PAI signal from melanin dots furnishes more comprehensive information on the tumour.Moreover,the heat generated after NIR laser irradiation can not only trigger the apoptosis of tumour cells but also promote the deeper penetration of Pt(Ⅱ)-based SCCs into tumour tissue,thus enhancing the efficiency of chemotherapy. 关 键 词：METALLACYCLES supramolecular coordination complexes chemo-photothermal therapy photoacoustic imaging melanin dots
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