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Tofu as excellent scaffolds for potential bone regeneration

查看全文 作　　者：Keqing [1,2]Huang;Guiting [1,2]Liu;Zhipeng [2,3]Gu;Jun [1,2]Wu 高影响力作者 机构地区：[1]Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province,School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006,China;[2]Research Institute of Sun Yat-sen University in Shenzhen,Shenzhen 518057,China;[3]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2020年第31卷第12期,共5页高影响力期刊 基　　金：the National Natural Science Foundation of China(No.51503129);Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029);the funding from the Science and Technology Program of Guangzhou(No.201707010094);Science and Technology Planning Project of Shenzhen(No.JCYJ20180307163534533)。 摘　　要：Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification.Hereon,we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering.In addition,the collagen has been introduced by simple coating to further enha nce the surface compatibility of the tofubased scaffold in bone regeneration.The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility.Notably,the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins,leading to better bone regeneration after 2 months of implantation.All the results indicated that to fu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities. 关 键 词：Bone regeneration Scaffolds TOFU COLLAGEN MACROPHAGES
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