Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery

查看全文 作　　者：Yaping [1]WANG;Songyue [1]CHENG;Wei [1]HU;Xue [1]LIN;Cong [1]CAO;Shufen [2]ZOU;Zaizai [1]TONG;Guohua [1]JIANG;Xiangdong [1]KONG

机构地区：[1]College of Materials Science and Engineering&Institute of Smart Biomedical Materials&Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China;[2]Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices,School of Chemistry,Biology and Materials Science,East China University of Technology,Nanchang 330013,China

出　　处：《Frontiers of Materials Science》索引2021年第15卷第1期,共15页

摘　　要：A glucose-mediated drug delivery system would be highly satisfactory fordiabetes diagnosis since it can intelligently release drug based on blood glucose levels.Herein,a glucose-responsive drug delivery system by integrating glucose-responsivepoly(3-acrylamidophenylboronic acid)(PAPBA)functionalized hollow mesoporous silicananoparticles(HMSNs)with transcutaneous microneedles(MNs)has been designed.Thegrafted PAPBA serves as gatekeeper to prevent drug release from HMSNs atnormoglycemic levels.In contrast,faster drug release is detected at a typicalhyperglycemic level,which is due to the change of hydrophilicity of PAPBA at highglucose concentration.After transdermal administration to diabetic rats,an effectivehypoglycemic effect is achieved compared with that of subcutaneous injection.Theseobservations indicate that the designed glucose-responsive drug delivery system has apotential application in diabetes treatment. 关键词：hollow mesoporous silica nanoparticles transdermal delivery DIABETES glucose-responsive release MICRONEEDLES

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Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery

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