维普中文期刊产品整合服务

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

查看全文 作　　者：Cheng [1]Li;Xiaolong [1]Tian;Xiaodong [2]Jia;Jinkai [3]Wan;Lu [1]Lu;Shibo [1]Jiang;Fei [3]Lan;Yinying [2]Lu;Yanling [1]Wu;Tianlei [1]Ying 高影响力作者 机构地区：[1]MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai,China;[2]Department of Comprehensive Liver Cancer,The Fifth Medical Center,Chinese PLA General Hospital,Beijing,China;[3]Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Institutes of Biomedical Sciences,Fudan University,Shanghai,China高影响力机构 出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第4期,共3页高影响力期刊 基　　金：This work was supported by grants from the National Key R&D Program of China(2019YFA0904400);National Natural Science Foundation of China(81822027,81630090);National Megaprojects of China for Major Infectious Diseases(2018ZX10301403,2018ZX10101003);the staff from Core Facility of Microbiology and Parasitology,Shanghai Medical College,Fudan University. 摘　　要：Dear Editor,The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and over 840,000 deaths globally.As the third severe respiratory disease outbreak caused by the coronavirus,COVID-19 has led to much larger infected populations and coverage of geographic areas than SARS and MERS.Such high prevalence of infection has raised significant concerns about the emergence and spread of escape variants,which may evade human immunity and eventually render candidate vaccines and antibody-based therapeutics ineffective.Indeed,some naturally mutated SARS-CoV or MERS-CoV strains from the sequential outbreaks were reported to resist neutralization by the antibodies isolated during the first outbreak1,2. 关 键 词：IMMUNITY eventually RENDER
相关文献

参考文献(9)

引证文献(2)

耦合文献(7)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费