Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

查看全文 作　　者：Honglei [1]Chen;Edward J [1]Zhao;Wen [1]Zhang;Yi [2]Lu;Rui [1]Liu;Xuemei [3]Huang;Anna J Ciesielski-[2]Jones;Michele A [2]Justice;Deborah S [2]Cousins;Shyamal [4]Peddada

机构地区：[1]Epidemiology Branch,National Institute of Environmental Health Sciences,111 T.W.Alexander Dr.,P.O.Box 12233,Mail drop A3-05,Research Triangle Park,NC 27709,USA;[2]Social&Scientific Systems,Inc.,Durham,North Carolina,USA;[3]Departments of Neurology,Radiology,Neurosurgery,Pharmacology,&Kinesiology,Pennsylvania State University-Milton S.Hershey Medical Center,Hershey,Pennsylvania,USA;[4]Biostatistics Branch,National Institute of Environmental Health Sciences,Research Triangle Park,NC,USA

出　　处：《Translational Neurodegeneration》索引2015年第4卷第1期,共8页

基　　金：by the intramural research program of the NIH,the National Institute of Environmental Health Sciences(Z01-ES-101986). 摘　　要：Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. 关键词：Parkinson’s disease Nonmotor symptoms Meta-analysis PREVALENCE Natural history

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Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

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