The neuroprotective efets of total flavones of Dracoce phalum moldavica L.on Parkinson's disease model in mouse

查看全文 作　　者：Zhou [1]Lili;Mo [1]Chaoran;Liu [1]Xinlang;Sun [1]yihong;Jia [1]Jianxin;Yang [1]Zhanjun 机构地区：[1]Baotou Medical College,Baotou 014040 出　　处：《解剖学杂志》索引2021年第44卷第S01期,共1页 摘　　要：It was found that the extract of total flavones from Dracoce phalum moldavica L.(TFD)could exert neuroprotective effect on moase Parkinson's disease(PD)model,but the underlying mechanisms remained unclear.The aim of this study was to detect the mechanisms of TFD neuroprotective effect on PD mice.The PD model was established by injection with MPTP to mice.Using behavioral experiment and ELISA test as well as immunohistochemistry and Western blot analysis,the following parameters were examined:①the falling latency and climbing time,②the content of serum MDA as well as activities of SOD and GSH-Px,③the count of dopaminergic neurons with expression of TH in the substantia nigra of model mice,and④the expression levels of TH,caspase-3,Bcl-2 and Bax in the midbrain tissue. 关 键 词：protective flavones IMMUNOHISTOCHEMISTRY