Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

查看全文 作　　者：Kendra [1,2]AMcClure;YuiHui [3]Gong;Jun [2]Song;Melinda Vinqvist-[2]Tymchuk;Leslie Campbell [2]Palmer;Lihua [2]Fan;Karen Burgher-[2]MacLellan;ZhaoQi [3]Zhang;Jean-Marc [4]Celton;Charles [2]FForney;[1]ZoëMigicovsky;Sean [1]Myles

机构地区：[1]Department of Plant and Animal Sciences,Faculty of Agriculture,Dalhousie University,Truro,NS B2N 5E3,Canada;[2]Agriculture and Agri-Food Canada,Kentville Research and Development Centre,Kentville,NS B4N 1J5,Canada;[3]College of Horticulture,South China Agriculture University,Guangzhou 510642,China;[4]IRHS,Agrocampus-Ouest,INRA,Universitéd’Angers,SFR 4207 QuaSaV,Beaucouzé,France

出　　处：《Horticulture Research》索引2019年第6卷第1期,共12页

基　　金：supported in part by funding from the Canada Research Chairs program(SM),the National Sciences and Engineering Research Council of Canada(SM),and A-Base funding(NOI-1767)from Agriculture and Agri-Food Canada(JS).ZM was supported by NSF 1546869. 摘　　要：Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing,primarily as dietary antioxidants.Although numerous pre-and post-harvest factors can affect the composition of polyphenols in apples,genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple cultivars.Here we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography(HPLC)data with~100,000 single nucleotide polymorphisms(SNPs)from two diverse apple populations.We found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars,and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic loci.Using GWAS,we identified candidate genes for the production of quercitrin,epicatechin,catechin,chlorogenic acid,4-O-caffeoylquinic acid and procyanidins B1,B2,and C1.Our observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through markerassisted breeding or gene editing. 关键词：EFFECT APPLE CULTIVAR

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Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

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