Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro

查看全文 作　　者：Zhengyuan [1]Wang;Yao [2]Zhao;Qingxing [3]Wang;Yangfei [1]Xing;Lu [2]Feng;Juan [2]Kong;Chao [4]Peng;Leike [3]Zhang;Haitao [2]Yang;Min [1]Lu

机构地区：[1]Shanghai Institute of Hematology,State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine(Shanghai),Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China;[2]Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology,ShanghaiTech University,Shanghai,China;[3]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,China;[4]National Facility for Protein Science in Shanghai,Zhangjiang Lab,Shanghai Advanced Research Institute,Chinese Academy of Science,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第7期,共4页

基　　金：M.L.was funded by the NSFC(82073292,81622002,81861130368);the SJTU Trans-med Awards Research,the Gaofeng Clinical Medicine Grant(828318);the Shanghai Excellent Youth Academic Leader Program(20XD1422700);the Shanghai Medical and Health Excellent Discipline Leader Development Plan(2018BR36);Shanghai Collaborative Innovation Center for Translational Medicine(TM201902);the Foundation of the National Facility for Translational Medicine(Shanghai)(TMSK-2020-003);the Newton Advanced Fellowship,and the Samuel Waxman Cancer Research Foundation.H.Y.was funded by the Science and Technology Commission of Shanghai Municipality(20431900200);the Department of Science and Technology of Guangxi Zhuang Autonomous Region(2020AB40007);L.Z.was funded by the NSFC(31970165). 摘　　要：Dear Editor,Since the beginning of 2020,the Coronavirus(CoV)Disease 2019(COVID-19)pandemic has posed formidable challenges to public health security.The main protease(Mpro,3CLpro)of CoVs plays essential roles in viral replication,making them attractive targets for antiviral drug development. 关键词：ATTRACTIVE development CASPASE

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Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro

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