Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

查看全文 作　　者：Lunzhi [1]Yuan;Huachen [2,3]Zhu;Ming [1]Zhou;Jian [1]Ma;Rirong [2,3]Chen;Liuqin [2,3]Yu;Wenjia [2,3]Chen;Wenshan [2,3]Hong;Jia [2,3]Wang;Yao [1]Chen;Kun [1]Wu;Wangheng [1]Hou;Yali [1]Zhang;Shengxiang [1]Ge;Yixin [1]Chen;Quan [1]Yuan;Qiyi [4]Tang;Tong [1]Cheng;Yi [2,3]Guan;Ningshao [1,5]Xia

机构地区：[1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Life Sciences,School of Public Health,Xiamen University,Xiamen 361000,China;[2]State Key Laboratory of Emerging Infectious Diseases,The University of Hong Kong,Hong Kong,China;[3]Joint Institute of Virology(Shantou University and The University of Hong Kong),Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases,Shantou University,Shantou 515063,China;[4]Department of Microbiology,Howard University College of Medicine,Washington,DC 20059,USA;[5]Research Unit of Frontier Technology of Structural Vaccinology,Chinese Academy of Medical Sciences,Xiamen 361102,China

出　　处：《Protein & Cell》索引2022年第13卷第1期,共6页

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)worldwide.Lungs are the primary target organ of SARS-CoV-2 infection.The mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less investigated.Several clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients. 关键词：ACUTE IMPAIRED PATHOGENESIS

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Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

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