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Glioblastoma vaccine tumor therapy research progress

查看全文 作　　者：Tong [1]Zhao;Chunwang [1]Li;Hongliang [1]Ge;Yuanxiang [1,2,3]Lin;Dezhi [1,2,3,4,5]Kang 高影响力作者 机构地区：[1]Department of Neurosurgery,Neurosurgery Research Institute,the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,People’s Republic of China;[2]Fujian Key Laboratory of Precision Medicine for Cancer,the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,People’s Republic of China;[3]Key Laboratory of Radiation Biology of Fujian higher education institutions,the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,People’s Republic of China;[4]Clinical Research and Translation Center,the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,People’s Republic of China;[5]Fujian Institute for brain disorders and brain science,the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,People’s Republic of China高影响力机构 出　　处：《Chinese Neurosurgical Journal》索引2022年第8卷第2期,共5页高影响力期刊 基　　金：This work was supported by Joint Funds for the Innovation of Science and Technology, Fujian Province(No. 2020Y9103);Fujian Provincial Health Technology Project(No.2021QNA025) 摘　　要：Glioblastoma(GBM)is the most common primary malignancy of the central nervous system in adults.The prognosis for late-stage glioblastoma(World Health Organization grade IV astrocytic glioma)is very poor.Novel treatment options are sought after and evaluated by clinicians and researchers,and remarkable advances have been made in surgical techniques,radiotherapy,and chemotherapy.However,the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few months.There has been notable progress in the field of immunotherapy,particularly with the use of tumor vaccines,for treating glioblastoma;especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell vaccines.However,the results of the current clinical trials for vaccination are not satisfactory.This article reviews the progress in the development of vaccines for glioblastoma. 关 键 词：GLIOBLASTOMA Vaccine therapy IMMUNOTHERAPY Tumor microenvironment REVIEW
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