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Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract

查看全文 作　　者：Xiaolin [1,2]Liu;Yue [1,2]Ma;Ying [1,2]Yu;Wenhui [1,2]Zhang;ingjing [1]Shi;Xuan [1]Zhang;Min [1]Dai;Yuhan [2,4,5,6]Wang;Hao [2,4,5,6]Zhang;Jiahe [2,4,5,6]Zhang;Jianghua [2,4,5,6]Shen;Faming [3,7]Zhang;Moshi [2,4,5,6]Song;Jun [1,2]Wang 高影响力作者 机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;[2]UniversityofChineseAcademyof Sciences,Beijing100049,China;[3]Medical Center for Digestive Diseases,the Second Affliated Hospital of Nanjing Medical University,Nanjing 210011,China;[4]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing,100101,China;[5]Institute for Stem cell and Regeneration,Chinese Academy of Sciences,Beijing,100101,China;[6]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China;[7]Key Lab of Holistic Integrative Enterology,Nanjing Medical University.Nanjing 210011,China高影响力机构 出　　处：《Protein & Cell》索引2023年第14卷第4期,共5页高影响力期刊 基　　金：supported by the National Key Research and Development Program of China(2018YFC2000500);the National Natural Science Foundation of China(91857101);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020000);the National Natural Science Foundation of China(81922027,81870228,and 81921006);Beijing Natural Science Foundation(Q20031)and the State Key Laboratory of Membrane Biology. 摘　　要：Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). 关 键 词：ORGANS INTESTINE CIRCADIAN
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