Tannin inhibits HIV-1 entry by targeting gp41

查看全文 作　　者：[1]LinLUE;Shu-[2]wenLIU;Shi-[2]boJIANG;Shu-[1]guangWU

机构地区：[1]InstituteofPharmacenticalSciencesoftheFirstMediealUniversityofPLA,KeyLabofGDforScreeningofNewDrug,Guangzhou,Guangdong510515,China;[2]LindsleyFKimballResearchInstitute,NewYorkBloodCenter,NewYork,NY10021,USA

出　　处：《Acta Pharmacologica Sinica》索引2004年第25卷第2期,共6页

基　　金：This project was supported by the National High Technology Foundation of China ('863' Project: 2001AA214201); National Natural Science Foundation of China (301400220); Chinese Army Medical Science and Technology Foundation (01Z051);Guangdong P 摘　　要：AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell. 关键词：丹宁酸人类免疫缺陷病毒-1 艾滋病靶细胞病毒复制 ELISA

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Tannin inhibits HIV-1 entry by targeting gp41

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