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| 1 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 4 | Blockade of the Bcr - abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5 - dependent expression of Bcl - X1 显示文摘 | Horita M Andreu E J Benito A | 2000 | J Exp Med2000，191，6： | 1 |
| 5 | Epidemiology of sepsis in the Valencian Community (Spain),1995-2004显示文摘 | Andreu Ballester J C Ballester F González Sánchez A | | 0，，7： | 1 |
| 6 | Familial multiple symmetric lipomatosis assoeiated with the A8344G mutation of mitochondrial DNA显示文摘 | Gamez J Playan A Andreu AL | 1998 | Neurology1998，51，1： | 1 |
| 7 | An analysis of e-business adoption and itsimpact on relational quality in travel agency-supplier relationships显示文摘 | Andreu L Aldás J Bigné J E Mattila A S (2010) | 2010 | Tourism Management2010，，： | 1 |
| 8 | Epidemiology of sepsis in the Valencian Community(Spain),1995-2004显示文摘 | Andreu Ballester JC Ballester F González Sánchez A | 2008 | Infect Control Hospital Epidemiol2008，29，7： | 1 |
| 9 | Ureaplasma urealyticum and pertussis-like syndrom显示文摘 | Ferrer Marcelles A Moraga-Hop FA Andreu Domingo A | 2000 | An Esp Rediatr2000，52，3： | 1 |
| 10 | B2B services 1T adoption in travel agency supply chains显示文摘 | Bigné J E Ald(a)s J Andreu L(2008) | 2008 | Journal of Services Marketing2008，，： | 1 |
| 11 | Blockade, of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5- dependent expression of Bcl-XI显示文摘 | Horita M Andreu EJ Benito A | 2000 | J Exp Med2000，191，6： | 1 |
| 12 | Accumulation of cytosolic glyceraldehydes-3-phosphate dehydrogenase RNA under biological stress conditions and elicitor treatments in potato显示文摘 | Laxalt A M Cassia R O Sanllorenti P M Madrid E A Andreu A B Daleo GR Conde R D Lamattina L | | 0，，： | 1 |
| 13 | Acute cellular rejection in liver transplant recipients under cyclosporine immunosuppression:predictive factors of response to antirejection therapy显示文摘 | Andreu H Rimola A Bruguera M Navasa M Cirera I Grande L | 2002 | Transplantation2002，73，： | 1 |
| 14 | Mechanical properties of cross-linked collagen meshes after human adipose derived stromal cellsseeding显示文摘 | Ochoa I Pea E Andreu EJ | 2011 | J Biomed Mater Res A2011，96，2： | 1 |
| 15 | Diseases of oxidative phosphorylation due to mtDNA mutations 显示文摘 | DiMauro S Andreu A L Musumeci O Bonilla E | 2001 | Semin Neurol2001，21，3： | 1 |
| 16 | Pneumonia presentation of an endobronchial chondroma 显示文摘 | Pastir E Andreu A Llombart M | 2004 | An Med Interna2004，21，11： | 1 |
| 17 | Sequence analysis of the entire mitochondrial genome in parkinson's disease 显示文摘 | Vives-Bauza C Andreu A Manfredi G | 2002 | Biochem Biophys Res Commtm2002，290，： | 1 |
| 18 | Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA 显示文摘 | ANDREU A L HANNA M G REICHMANN H | 1999 | N EnglJMed1999，341，14： | 1 |
| 19 | A receptor for the enantioselective recognition of phenylalanine and tryptophan under neutral conditions 显示文摘 | GALAN A ANDREU D ECHAVARREN A M | 1992 | J Americ Chem Soc1992，114，4： | 1 |
| 20 | Modeling,simulation and control of event-driven operations in process systems显示文摘 | R Vallette H pingaud A Pages D Andreu J C Pascal | 1995 | FTFA 95 Proceodings1995，3，： | 1 |
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