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| 1 | Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis显示文摘Histone acetylation/deacetylation 是一个动态过程并且在基因规定起一个重要作用。Histone acetylation 动态平衡被 histone acetyltransferases (帽子) 和 deacetylases (HDAC ) 的对手行动调整。植物染色体编码多重帽子和 HDAC。在许多植物开发的一个必要角色处理的 Arabidopsis 帽子基因 AtGCN5/HAG1plays 例如分裂组织功能,房间区别,叶和花的 organogenesis ,并且对象光和寒冷那样的环境条件的回答,在长期的发展开关和短期的可诱导的基因表示的规定显示这顶帽子的一个重要角色。AtGCN5 目标到很多倡导者并且为几 histone H3 离氨酸残余的 acetylation 被要求。到目标倡导者的 AtGCN5 的招募是可能的被和 DNA 有约束力的抄写因素的直接或间接的相互作用或由和 acetylated histone 离氨酸残余的相互作用在目标上调停。在 AtGCN5 和另外的帽子和 HDAC 之间的相互影响被表明控制特定的规章的小径。在光可诱导的基因表示的 AtGCN5 的角色的分析在为 priming 准备染色质承诺建议 AtGCN5 的功能在植物的可诱导的基因激活。 | Caroline Servet Natalia Conde e Silva Dao-Xiu Zhou | 2010 | Molecular Plant2010，3，4： | 14 |
| 2 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 3 | Forest Biodiversity Assessment in Peruvian Andean Montane Cloud Forest显示文摘Cloud forests are unusual and fragile habitats, being one of the least studied and least understood ecosystems. The tropical Andean dominion is considered one of the most significant places in the world as regards biological diversity, with a very high level of endemism. The biodiversity was analysed in an isolated remnant area of a tropical montane cloud forest known as the 'Bosque de Neblina de Cuyas', in the North of the Peruvian Andean range. Composition, structure and dead wood were measured or estimated. The values obtained were compared with other cloud forests. The study revealed a high level of forest biodiversity, although the level of biodiversity differs from one area to another: in the inner areas, where human pressure is almost inexistent, the biodiversity values increase. The high species richness and the low dominance among species bear testimony to this montane cloud forest as a real enclave of biodiversity. | Alicia Ledo Sonia Condés Iciar Alberdi | 2012 | Journal of Mountain Science2012，9，3： | 5 |
| 4 | Stand-level biomass models for predicting C stock for the main Spanish pine species显示文摘Background:National and international institutions periodically demand information on forest indicators that are used for global reporting.Among other aspects,the carbon accumulated in the biomass of forest species must be reported.For this purpose,one of the main sources of data is the National Forest Inventory(NFI),which together with statistical empirical approaches and updating procedures can even allow annual estimates of the requested indicators.Methods:Stand level biomass models,relating the dry weight of the biomass with the stand volume were developed for the five main pine species in the Iberian Peninsula(Pinus sylvestris,Pinus pinea,Pinus halepensis,Pinus nigra and Pinus pinaster).The dependence of the model on aridity and/or mean tree size was explored,as well as the importance of including the stand form factor to correct model bias.Furthermore,the capability of the models to estimate forest carbon stocks,updated for a given year,was also analysed.Results:The strong relationship between stand dry weight biomass and stand volume was modulated by the mean tree size,although the effect varied among the five pine species.Site humidity,measured using the Martonne aridity index,increased the biomass for a given volume in the cases of Pinus sylvestris,Pinus halepensis and Pinus nigra.Models that consider both mean tree size and stand form factor were more accurate and less biased than those that do not.The models developed allow carbon stocks in the main Iberian Peninsula pine forests to be estimated at stand level with biases of less than 0.2 Mg·ha^(-1).Conclusions:The results of this study reveal the importance of considering variables related with environmental conditions and stand structure when developing stand dry weight biomass models.The described methodology together with the models developed provide a precise tool that can be used for quantifying biomass and carbon stored in the Spanish pine forests in specific years when no field data are available. | Ana Aguirre Miren del Río Ricardo Ruiz-Peinado Sonia Condés | 2021 | Forest Ecosystems2021，8，2： | 4 |
| 5 | 几种有机化合物的激光喇曼光谱研究显示文摘本文报道了由实验测定的丙酮、乙醇、乙二醇、异丙醇、甲苯、乙醚、正丁醇和甲酰胺等8个有机化合物在200-3500cm-1范围内的激光喇曼光谱,发现了一些新的正则振动模,并讨论了这些振动模的性质. | Conde Karamoko 李春燕 张瑾 季学韩 崔执凤 | 2004 | 安徽师范大学学报(自然科学版)2004，27，3： | 3 |
| 6 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 7 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 8 | Triiodothyronine and breast cancer显示文摘The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis. | Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 9 | Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support显示文摘 | Paul A. Harris Robert Taylor Robert Thielke Jonathon Payne Nathaniel Gonzalez Jose G. Conde | 2008 | Journal of Biomedical Informatics2008，，2： | 2 |
| 10 | Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease显示文摘 | Wing–Kin Syn Youngmi Jung Alessia Omenetti Manal Abdelmalek Cynthia D. Guy Liu Yang Jiangbo Wang Rafal P. Witek Caitlin M. Fearing Thiago A. Pereira Vanessa Teaberry Steve S. Choi J. Conde–Vancells Gamze F. Karaca Anna Mae Diehl | 2009 | Gastroenterology2009，，4： | 2 |
| 11 | Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles显示文摘为特定的基因 silencing 的小介入 RNA (siRNAs ) 的治疗学的诺言依赖于到细胞质的功能的 siRNAs 的成功的交货。他们到一个确定的交货平台的变化形式例如金 nanoparticles,为治疗疾病并且推进我们细胞的过程的理解提供巨大的潜力。他们的成功或失败依赖于两个进房间和功能的 siRNA 的随后的细胞内部的版本的 nanoparticles 的举起。在这研究,利用金 nanoparticle 对 C-MYC 的 调停siRNA 的交货,我们试图决定我们是否能完成在一个癌症房间击倒与细胞内部的谷胱甘肽的底层排队,并且如果有的话,聚乙烯乙二醇(木钉)决定影响 ligand 密度在上击倒,考虑到决定最佳的 nanoparticle 设计完成 C-MYC 击倒。我们表明那,不管木钉密度,在有相对低的谷胱甘肽层次的房间击倒能被完成,以及为在细胞内部的环境的劈开的 siRNA 的可获得性上的木钉的位的阻碍者的可能的效果。当击倒时,金 nanoparticle 举起经由传播电子显微镜学和集体光谱学被表明被在里面房间 westerns 和 BrdU 加入分别地在蛋白质和生理的层次(在 S 阶段的房间) 决定。 | Mark McCully Yulan Hernandez Joao Conde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling Catherine C. Berry | 2015 | Nano Research2015，8，10： | 2 |
| 12 | Postpartum hemolytic uremic syndrome:a rare entity and a treatment challenge 显示文摘 | Alsina Segui E Martin Conde M Craver Hospital L Fernandez Oiraldez E | 2008 | Nefrologia2008，28，： | 1 |
| 13 | Ice in prefermented frozen bread dough-an investigation based on calorimetry and microscopy显示文摘 | Baier S A Handschin S Conde P B | 2005 | Cereal Chemistry2005，82，6： | 1 |
| 14 | Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis显示文摘 | García S Mera A Conde C | 2009 | Rheumatology (Oxford)2009，48，5： | 1 |
| 15 | Cladding of Ni-Cr-B-Si coatings with a high power diode laser显示文摘 | Conde A Zubiri F Damborenea J | 2002 | Materials Science and Engineering A2002，334，2： | 1 |
| 16 | Cigarette smoking during pregnancy and risk of preeclampsia:a systematic review显示文摘 | Conde Qgudelo A Althabe F Belizan JM | 1999 | Am J Obstet Gynecol1999，181，： | 1 |
| 17 | Cladding of Ni2Cr2B2Si Coatings with a High Power Diode Laser显示文摘 | Conde A Zubiri F de Damborenea J | 2002 | Materials Science and Engineering A2002，33，4： | 1 |
| 18 | Determination of esters in dry and sweet white wines by headspace solid-phase microextraction and gas chromatography 显示文摘 | RODRIGUEZ-BENCOMO J J CONDE JE RODRIGUEZ-DELGADO MA | 2002 | J Chromatogr A2002，963，： | 1 |
| 19 | Microtubule assembly, organization and dynamics in axons and dendrites 显示文摘 | CONDE C CACERES A | 2009 | Nat Rev Neurosci2009，10，5： | 1 |
| 20 | Quality of life and ad- verse events after radiotherapy in gynecologic caneer survivors: a cohort study 显示文摘 | Vaz AF Conde DM Costa - Paival | 2011 | Arch Gynecol Obstet2011，284，6： | 1 |
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