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| 1 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 2 | -MSH inhibits inflammatory signaling in Schwann cells显示文摘 | Teare Katrina A Pearson Richard G Shakesheff Kevin M | 2004 | NeuroReport2004，15，3： | 1 |
| 3 | Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients 显示文摘 | Lamont J M McManamy C S Pearson A D | 2004 | Clin Cancer Res2004，10，： | 1 |
| 4 | A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer显示文摘 | Alvarez E A Wolfson A H Pearson J M | 2009 | Gynecol Oncol2009，113，2： | 1 |
| 5 | Development of a calibration to predict maize seed composition using single kernel near infrared spectroscopy显示文摘 | Baye T M Pearson T C Settles A M | 2006 | Journal of Cereal Science2006，43，： | 1 |
| 6 | Chicken flavor: The identification of some chemical components and the importance of sulfur compounds in the cooked volatile fraction显示文摘 | Minor L J Pearson A M Dawson L E | 1965 | Journal of Food Science1965，30，4： | 1 |
| 7 | The state of pediatric interfacility transport: consensus of the second National Pediatric and Neonatal Interfacility Transport Medicine Leadership Conference 显示文摘 | Woodward G A Insoft R M Pearson Shaver A L | 2002 | Pediatr E- merg Care2002，18，1： | 1 |
| 8 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 9 | Schistosome membrane proteins as vaccines 显示文摘 | Loukas A Tran M Pearson MS | 2007 | Int J Parasitol2007，37，3： | 1 |
| 10 | Assessment of chemotherapy-associated nephrotoxicity in children with cance显示文摘 | SKINNE R PEARSON A D COULTHARD M G | 1991 | Cancer chemotherapy pharmacology1991，28，2： | 1 |
| 11 | Retinal repair by transplantation of photoreceptor precursors显示文摘 | MacLaren RE Pearson RA MacNeil A Douglas RH Salt TE Akimoto M | 2006 | Nature2006，444，7116： | 1 |
| 12 | Under-standing the dynamics of new venture top managementteams cohesion,conflict,and new venture performance显示文摘 | ENSLEY M D PEARSON A W AMASON A C | 2002 | Journal of Business Venturing2002，17，： | 1 |
| 13 | Quantitative analysis of trace elements in geolog-ical materials by laser ablation ICP-MS: Instru- mental operating conditions and calibration values of NIST glassesp显示文摘 | Norman M D Pearson N J Sharma A | 1996 | Geostandards newsletter1996，20，： | 1 |
| 14 | In vitro investigation of fluoride ion release from four resin-modified glass polyalkenoate cements显示文摘 | Musa A Pearson GJ Gelbier M | 1996 | Biomaterials1996，17，10： | 1 |
| 15 | Testing Huntington:Is Hispanic Immigration a Threat to American Identity显示文摘 | LERMAN A NURAKAMI M and PEARSON K | 2007 | Perspectives on Politics2007，，： | 1 |
| 16 | Refraining crisis management显示文摘 | Pearson C M Clair J A | 1998 | Academy of Management Review1998，23，1： | 1 |
| 17 | Lipid oxidation in meat and meat products: a review显示文摘 | LOVE J D PEARSON A M | 1971 | Journal of the American Oil Chemists'' Society1971，48，10： | 1 |
| 18 | Inhibition of chlorophyll synthesis in Hordeum vulgare by 3-amino 2,3-dihydrobenzoic acid (gabaculin)显示文摘 | HILL C M PEARSON S A SMITH AJ | 1985 | Bioscience Reports1985，5，9： | 1 |
| 19 | Anterior chamber implantation after vitreous loss 显示文摘 | PEARSON P A OWEN D G MALISZEWSKI M | 1989 | Br J Ophthalmol1989，73，7： | 1 |
| 20 | Spectral filters and temperature effects on the growth and development of chrysanthemums under low light integral显示文摘 | Khattak A M Pearson S | 2006 | Plant Growth Regul2006，49，： | 1 |
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