|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010显示文摘Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. | Chakshu Sharma Karim M Eltawil Paul D Renfrew Mark J Walsh Michele Molinari | 2011 | World Journal of Gastroenterology2011，17，7： | 28 |
| 2 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 3 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 4 | 一个新型的毫米波无线信号光纤传输系统及本振信号远程传送结构(英文)显示文摘提出一个新型的毫米波光纤传输系统及本振信号远程传送的结构.此技术能为将来使用皮蜂窝网络提供宽带无线接入服务给出一个简单的基站接入点解决方案.计算和仿真结果表明,在激光器输出功率为-6.5 dBm,光放大增益为6 dB,激光线宽为1 MHz,75 MHz或150 MHz,误码率不超过10-9的情形下,622 Mbit/s的下行相移键控信号能够在传统单模光纤上传输超过30 km的距离.在具有相对大的激光器线宽150 MHz和光纤距离为30 km时,由激光器相位噪音和光纤色散所引起的(通过远程传送的)毫米波本振信号的额外相位误差的方差仅为1.74°. | 周明拓 Sharma A B 张建国 Fujise M | 2006 | 光子学报2006，35，11： | 7 |
| 5 | Adherence to self-care practices, glycemic status and influencing factors in diabetes patients in a tertiary care hospital in Delhi显示文摘AIM To assess the adherence to self-care practices,glycemic status and influencing factors in diabetes patients.METHODS This was a cross-sectional observational analysis of baseline data from a quasi-experimental study conducted among 375 diabetic patients aged between 18 to 65years at a major public tertiary care centre in New Delhi,India during February-September’2016.The Summary of Diabetes Self-care activities measure was used to assess medical adherence in diabetic patients.Open ended questions were used to identify facilitators and inhibitors of medical adherence.RESULTS Mean age of the study subjects was 49.7±10.2 years.A total of 201 men and 174 women were enrolled in the study.Three hundred nine(82.4%)subjects were adherent to their intake of anti-diabetic medication.On binary logistic regression,education level below primary school completion and absence of hypertensioncomorbidity were found to be independent predictors of medication non-adherence.Sociocultural resistance was an important factor impeding outdoor exercise among younger women.Knowledge of diabetes in the study subjects was low with mean score of 3.1±2(maximum score=10).Suboptimal glycemic control was found in259(69%)subjects which was significantly more likely in patients on Insulin therapy compared to those on Oral Hypoglycemic agents alone(P<0.006).DISCUSSION Our study found a large gap existed between selfreported medication adherence and glycemic control.This suggests the need for enhanced physician focus for diabetic patient management. | Saurav Basu Suneela Garg Nandini Sharma M Meghachandra Singh Sandeep Garg | 2018 | World Journal of Diabetes2018，9，5： | 4 |
| 6 | Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India显示文摘瞄准:描述播送输送的病毒(TTV ) 的流行与在在诺思 India.METHODS 的肝疾病的不同形式的肝炎 A-E 病毒的感染联合的感染:从一个总数的血清 137 个病人数,包括 37 有尖锐病毒的肝炎( AVH )的病人,有长期的病毒的肝炎( CVH )的 37 个病人,有肝硬变的 31 个病人和有暴发性的肝的失败( FHF )的 32 个病人,为 TTV-DNA 和肝炎 A-E 病毒的标记两个都被分析。肝炎 B (HBV ) 的存在,丙肝病毒(HCV ) 和肝炎 E 病毒(HEV ) 感染在不同的组在不同比例被检测。而且, TTV-DNA 同时在 100 健康供血者 also.RESULTS 被测试:任何一个都没病人有肝炎 A 病毒(HAV ) 和肝炎 D 病毒(HDV ) 感染。TTV-DNA 的全面流行与 FHF 与 AVH,有 CVH 的 18.9% 盒子,有肝硬化的 48.4% 盒子和 9.4% 盒子在 27.1% 情况中被检测。同时在 100 健康供血者测试的 TTV-DNA 显示出 27% 确实。在与另外的肝炎建立在 TTV 感染之间的一种关系上病毒的感染, TTV 在这些疾病组与 HBV, HCV 和 HEV 表明了合作感染。有中高音的 TTV 的关联在重量的单位铺平一没在感染 TTV 的病人表明高中高音水平,建议那 TTV 不引起严重的肝 damage.CONCLUSION:TTV 感染在印度在病人和健康个人两个都是流行的。然而,它没与另外的肝炎有任何重要关联病毒的感染,它也不与肝疾病在病人生产严重的肝损坏的一条证据。 | M Irshad Y Sharma I Dhar J Singh YK Joshi | 2006 | World Journal of Gastroenterology2006，12，15： | 3 |
| 7 | Transfusion transmitted virus: A review on its molecular characteristics and role in medicine显示文摘现在的评论给输送的更新的概述播送病毒(TTV ) ,一个新奇代理人在与它的分子的特征的关系,流行病学的特征,传播的模式,组织向性,致病,在各种各样的疾病的角色和它从身体的根除。TTV,一个 DNA 病毒,一个单身者被搁浅,非包,有包括 3852 的一个小、 covalently 关上的圆形的染色体的长 DNA 病毒基于的 3.8 kb。它是尝试性地指明的 Circinoviridae 病毒。TTV 染色体顺序是异构的并且揭示六不同遗传型和几种子类型的存在。TTV 被报导了不仅经由非肠道的线路,而且经由交替的线路播送。这个病毒也在不同非人类的首领被检测了。目前, TTV 被聚合酶链反应(PCR ) 没有另外的可得到的诊断试金检测。它全球性显示出它的存在并且在健康的人的高百分比人口以及在各种各样的疾病组被检测。开始,它应当与肝疾病有强壮的协会;然而,几乎没有小证据在引起肝疾病显示出它的肝向性和贡献。它在牙齿过敏细胞溶解病人显示出高流行,向它在肾的疾病的意义指。另外, TTV 与几传染、非传染的疾病被联系。不过,它的准确致病是还没清楚的, TTV 病毒可能住并且在骨髓房间和外部血乘单音的原子房间(PBMC ) 。最近,被尝试了根除有干扰素治疗的这个病毒。更多的信息仍然被需要解脱与 TTV 有关的各种各样的谜。 | M Irshad YK Joshi Y Sharma I Dhar | 2006 | World Journal of Gastroenterology2006，12，32： | 3 |
| 8 | Interdependent regulation of intracellular acidification and SHP-1 in apoptosis显示文摘 | Thangaraju M Sharma K Liu D | 1999 | Cancer Res1999，59，： | 2 |
| 9 | p53 protein overexpression in low grade dysplasia (LGD) in barrett’s esophagus: Immunohistochemical marker predictive of progression显示文摘 | Allan P Weston Sushanta K Banerjee Prateek Sharma Trang M Tran Robert Richards Rachel Cherian | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 10 | Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients显示文摘 | Sharma K Robert V Beckie M | 1997 | Kidney Inter1997，51，： | 2 |
| 11 | Role of ligaments and facets in lumbar spinal stability显示文摘 | Sharma M Lanrana NA Rodriguez J | 1995 | Spine1995，20，6： | 1 |
| 12 | Salt-stress-induced proline accumulation in germinating embryos:Evidence suggesting a role of proline in seed germination显示文摘 | THAKUR M SHARMA A D | 2005 | Arid Environments2005，62，： | 1 |
| 13 | Epidemiological observation on goatpox in Himachal Pradesh 显示文摘 | BATTA M K KATOCH R C SHARMA M T | 1999 | Indian Vet J1999，76，8： | 1 |
| 14 | Angiotensin II receptor blockade:a novel strategy to prevent immunosup - pressant-associated cancer progression 显示文摘 | Maluccio M Sharma V Lagman M | 2001 | Transplant Proc2001，33，： | 1 |
| 15 | Effect of surfactant on leaching of pendimethalin in Florida candler fine sand显示文摘 | Sharma S D Singh M | 2007 | Bull Environ Contam Toxicol2007，78，： | 1 |
| 16 | Histological analysis of lesions of the pineal region:a retrospective study of 12 years显示文摘 | Kumar P Tatke M Sharma A | 2006 | Pathol Res Pract2006，202，2： | 1 |
| 17 | In-gel detection of urease activity by nitroprusside-thiol reaction 显示文摘 | SHARMA V CHAUDARY R KHURANA J M | 2008 | Phytochem Anal2008，19，2： | 1 |
| 18 | A Novel Approach To Investigate the Uptake and Internalization of Escherichia coli O157:H7 in Spinach Cultivated in Soil and Hydroponic Medium 显示文摘 | Sharma M Ingram D T Patel J R | 2009 | J Food Protection2009，72，7： | 1 |
| 19 | Persistently high HIV seroprevalence among adult tuberculosis patients at a tertiary care centre in Delhi显示文摘 | Piramanayagam P Tahir M Sharma SK | 2007 | Indian J Med Res2007，125，2： | 1 |
| 20 | Role of ligaments and facets in lumbar spinal stability 显示文摘 | Sharma M Langrana NA Rodriguez J | 1995 | Spine (Phila Pa 1976)1995，20，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员