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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 3 | Safety assessment of black cumin fixed and essential oil in normal Sprague Dawley rats: serological and hematological indices显示文摘 | TAUSEEF S M BUTT M S ANJUM F M | 2009 | Food and Chemistry Toxicology2009，47，： | 1 |
| 4 | Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery 显示文摘 | Kermode J Butt W Shann F | 1991 | Br Heart J1991，66，： | 1 |
| 5 | Pattern of head and neck malignant neoplasms in HIV-infecled pa tients in Kenya显示文摘 | Butt FM Chindia ML Rana F | 2008 | Int J Oral Maxillofac Surg2008，37，10： | 1 |
| 6 | Pattern of head and neck malignant neoplasms in HIV-infected patients in Kenya显示文摘 | Butt FM Chindia ML Rana F | 2008 | Int J Oral Maxillofac Surg2008，37，10： | 1 |
| 7 | Overview transient liquid phase bonding 显示文摘 | Gale W F Butts D A | 2004 | Science and Technology of Welding and Joining2004，9，4： | 1 |
| 8 | A pilot study assessing the prognostic value of CK18 and n DNA biomarkers in severe sepsis patients显示文摘 | Moore DJ Greystoke A Butt F | 2012 | Clin Drug Investig2012，32，3： | 1 |
| 9 | Characteriszation of foulants by autopsy of RO desalination membranes显示文摘 | Butt F H Rahman F Badumthamal U | 1997 | Desalination1997，114，： | 1 |
| 10 | Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache:a multi - center randomized clinical trial 显示文摘 | Dunning JR Butts R Mourad F | 2016 | BMC Musculoskelet Disord2016，17，1： | 1 |
| 11 | An intematioinal, multicenter, randomized phase III study of firstline erlotinib followed by second - line cisplatin/gemcitabine versus firstline cisplatin/gemcitabine followed by second - line erlotinib in advanced non - small - cell lung cancer: Treatment rationale and protocol dynamics of the TORCH trial 显示文摘 | Gridelli C Butts C Ciardiello F | 2008 | Clin Lung Cancer2008，9，4： | 1 |
| 12 | 查看详情显示文摘 | Feltin E Carlin J F Dorsaz J Christmann G Butte R Latigt M Ilegems M Grandjean N | | 0，，： | 1 |
| 13 | Evaluation of SHMP and advanced scale inhibitor for control of CaSO4,SrSO4 and CaCO3 scales in RO desalination显示文摘 | F H Butt F Rahman U Baduruthamal | 1997 | Desalination1997，109，3： | 1 |
| 14 | Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance显示文摘 | Sun Y Butte N F Garcia J M | 2008 | Endocrinology2008，149，2： | 1 |
| 15 | TNF-alpha: a risk fac- tor for ischemic stroke 显示文摘 | Bokhari FA1 Shakoori TA Butt A Ghafoor F | 2014 | J Ayub Med Coil Abbottabad2014，26，2： | 1 |
| 16 | Rice Bran: A Novel Functional Ingredient 显示文摘 | Sharif M K Butt M S Anjum F M | 2014 | Critical reviews in food science and nutrition2014，54，6： | 1 |
| 17 | Numerical model of impact-damped continuous systems 显示文摘 | Butt A S Akl F A | 1997 | Journal of Engineering Mechanics1997，，： | 1 |
| 18 | An international multicenter, randomized phase Ⅲ study of first line erlotinib followed by second line cisplatin/gcmcitabine versus first line cisplatin/gemcitabine followed by second line erlotinib in ad vanced non small cell lung cancer; treatment rationale and protocol dynamics of the TORCH trial显示文摘 | Gridelli C Butts C Ciardiello F | 2008 | Clin Lung Canc- er2008，9，4： | 1 |
| 19 | Numerical model of impact-damped continu-ous systems显示文摘 | Butt A S Akl F A | 1997 | Journal of Engineering Mechanics1997，123，4： | 1 |
| 20 | De velopment of predictive models for end use quality of springwheat's through canonical analysis显示文摘 | Butt M S Anjum F M van Zuilichem D J Shaheen M | 2001 | International Journal of Food Science and Technology2001，36，： | 1 |
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