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| 1 | Gain in polycrystalline Nd-doped alumina: leveraging length scales to create a new class of high-energy, short pulse, tunable laser materials显示文摘Traditionally accepted design paradigms dictate that only optically isotropic(cubic)crystal structures with high equilibrium solubilities of optically active ions are suitable for polycrystalline laser gain media.The restriction of symmetry is due to light scattering caused by randomly oriented anisotropic crystals,whereas the solubility problem arises from the need for sufficient active dopants in the media.These criteria limit material choices and exclude materials that have superior thermo-mechanical properties than state-of-the-art laser materials.Alumina(Al_(2)O_(3))is an ideal example;it has a higher fracture strength and thermal conductivity than today’s gain materials,which could lead to revolutionary laser performance.However,alumina has uniaxial optical proprieties,and the solubility of rare earths(REs)is two-to-three orders of magnitude lower than the dopant concentrations in typical RE-based gain media.We present new strategies to overcome these obstacles and demonstrate gain in a RE-doped alumina(Nd:Al_(2)O_(3))for the first time.The key insight relies on tailoring the crystallite size to other important length scales—the wavelength of light and interatomic dopant distances,which minimize optical losses and allow successful Nd doping.The result is a laser gain medium with a thermo-mechanical figure of merit of R_(s)~19,500 Wm^(−1) a 24-fold and 19,500-fold improvements over the high-energy-laser leaders Nd:YAG(R_(s)~800Wm^(−1))and Nd:Glass(R_(s)~1Wm^(−1)),respectively.Moreover,the emission bandwidth of Nd:Al_(2)O_(3) is broad:~13 THz.The successful demonstration of gain and high bandwidth in a medium with superior R_(s) can lead to the development of lasers with previously unobtainable highpeak powers,short pulses,tunability,and high-duty cycles. | Elias H.Penilla Luis F.Devia-Cruz Matthew A.Duarte Corey L.Hardin Yasuhiro Kodera Javier E.Garay | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | A high‐order generalized FEM for through‐the‐thickness branched cracks显示文摘 | C. A.Duarte L. G.Reno A.Simone | 2007 | Int. J. Numer. Meth. Engng2007，，： | 1 |
| 3 | Recipient IL28B Polymorphism Is an Important Independent Predictor of Posttransplant Diabetes Mellitus in Liver Transplant Patients with Chronic Hepatitis C显示文摘 | B. J.Veldt A.Duarte‐Rojo A. J.Thompson K. D.Watt J. K.Heimbach H. L.Tillmann D. D.Goldstein J. G.McHutchison M. R.Charlton | 2012 | American Journal of Transplantation2012，，3： | 1 |
| 4 | Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies显示文摘The COVID-19 pandemic has posed enormous challenges for existing diagnostic tools to detect and monitor pathogens.Therefore,there is a need to develop point-of-care(POC)devices to perform fast,accurate,and accessible diagnostic methods to detect infections and monitor immune responses.Devices most amenable to miniaturization and suitable for POC applications are biosensors based on electrochemical detection.We have developed an impedimetric immunosensor based on an interdigitated microelectrode array(IMA)to detect and monitor SARS-CoV-2 antibodies in human serum.Conjugation chemistry was applied to functionalize and covalently immobilize the spike protein(S-protein)of SARS-CoV-2 on the surface of the IMA to serve as the recognition layer and specifically bind anti-spike antibodies.Antibodies bound to the S-proteins in the recognition layer result in an increase in capacitance and a consequent change in the impedance of the system.The impedimetric immunosensor is label-free and uses non-Faradaic impedance with low nonperturbing AC voltage for detection.The sensitivity of a capacitive immunosensor can be enhanced by simply tuning the ionic strength of the sample solution.The device exhibits an LOD of 0.4 BAU/ml,as determined from the standard curve using WHO IS for anti-SARS-CoV-2 immunoglobulins;this LOD is similar to the corresponding LODs reported for all validated and established commercial assays,which range from 0.41 to 4.81 BAU/ml.The proof-of-concept biosensor has been demonstrated to detect anti-spike antibodies in sera from patients infected with COVID-19 within 1 h. | Lian C.T.Shoute Gaser N.Abdelrasoul Yuhao Ma Pedro A.Duarte Cole Edwards Ran Zhuo Jie Zeng Yiwei Feng Carmen L.Charlton Jamil N.Kanji Shawn Babiuk Jie Chen | 2023 | Microsystems & Nanoengineering2023，9，1： | 0 |
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