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| 1 | 三峡工程对生态环境与生态系统的影响及政策分析模型研究显示文摘三峡工程作为一项世界举世瞩目的特大水利水电工程,一直备受公众的关注和争论,其利弊之争一直没有停止。其中,关于三峡工程对生态环境与生态系统的影响也是众说纷纭,但从总体上看,目前关于三峡工程对生态环境与生态系统影响的研究主要侧重于微观的、局部的、分学科的定量研究,而宏观的政府政策层面的研究比较少,尤其是关于三峡工程对生态环境和生态系统影响的政策分析模型研究更少,几乎没有。基于此,本文通过尽可能全面地收集、整理近些年来公开发表的权威资料和数据,在考虑经济、社会、环境和生态等多种因素影响下,通过分析和计算,运用环境影响经济损益的分析方法,从三峡水库对生态环境的影响因子中,筛选出起主导作用的几个因素,从经济价值的角度解释三峡工程对生态环境与生态系统的影响:即有利的影响主要是节能减排与防洪抗旱带来的经济效益,不利的影响主要是泥沙淤积、水污染和地质灾害。并通过进一步比较分析,结合权威专家的利弊观点梳理,得出三峡工程对生态环境与生态系统的总体影响是利大于弊的客观结论。在此基础上构建了改善三峡生态环境和生态系统影响政策分析体系模型,具体构建分析了五个方面的政策模型,并对政府政策进行了分析与建议,这五个方面的政策分析模型是:健全监督管理体制的政策分析模型;联动调度协调机制的科学管理的政策分析模型;采取'蓄清排浑'的政策分析模型;转变集中管理的水污染问题政策分析模型;建立多元主体防治与保护体系的地质灾害问题的政策分析模型。 | 王树文 祁源莉 Farhed A.Shah | 2015 | 中国人口·资源与环境2015，25，5： | 9 |
| 2 | Use of Sewage Sludge After Liming as Fertilizer for Maize Growth显示文摘农业土地上的污水污泥的使用为它的处理提供一种选择。因此,现在的学习的目的是评估使用在巴基斯坦生产的工业污水污泥的可行性,作为农业化肥。与 250 g kg 修改的农业土壤 ? 1 污水污泥与或没有石灰处理被用于普通本地谷类罪的生长,玉米(Zea 玉米) 。在污泥样品的踪迹和有毒的金属的活动性被使用一个修改 BCR 顺序的抽取过程估计。单个抽取过程由温和提炼之物(CaCl2 ) 和水的申请组成,为容易可溶的金属部分的比例的评价。为了在顺序的抽取过程的每步检查分析结果,踪迹的集中和有毒的金属的精确,被总结并且与全部的金属集中相比。植物可得到的金属满足,由 deionized 水和 0.01 摩尔 L 显示了? 1 CaCl2 答案抽取部分和顺序的抽取的可交换的部分,显著地减少了( P < 0.05 )用石灰申请因为在更高的 pH 的减少的金属可获得性,除了在 Cd 和 Cu 的情况中,其活动性是,稍微增加了。污泥改正提高了玉米的干燥重量收益,增加为有石灰处理的土壤是更明显的。施用石灰污水污泥在谷物纸巾减少了踪迹和有毒的金属内容除了 Cu 和 Cd,它在这些金属的可允许的限制下面。现在的实验证明施用石灰是在在修改污泥的土壤便于玉米的生长的一个重要因素。 | M.K.JAMALI T.G.KAZI M.B.ARAIN H.I.AFRIDI A.R.MEMON N.JALBANI A.SHAH | 2008 | Pedosphere2008，18，2： | 5 |
| 3 | Fast and sensitive LC–MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma显示文摘A sensitive and rapid liquid chromatography-tandem mass spectrometry(LC–MS/MS) method has been developed for the simultaneous determination of lisinopril(LIS) and hydrochlorothiazide(HCTZ) in human plasma using their labeled internal standards(ISs). Sample pre-treatment involved solid phase extraction on Waters Oasis HLB cartridges using 100 μL of plasma, followed by liquid chromatography on Hypersil Gold C_(18)(50 mm×3.0 mm, 5 μm) column. The analytes were eluted within 2.0 min using acetonitrile-5.0 m M ammonium formate, p H 4.5(85:15, v/v) as the mobile phase. The analytes and ISs were analyzed in the negative ionization mode and quantified using multiple reaction monitoring. The method showed excellent linearity over the concentration range of 0.50–250.0 ng/m L for both the analytes. The intra-batch and inter-batch precision(% CV) was ≤5.26% and their extraction recoveries were in the range of 96.6%–103.1%. Matrix effect evaluated in terms of IS-normalized matrix factors ranged from 0.97 to 1.03 for both the analytes. The validated method was successfully applied to determine the plasma concentration of the drugs using 10 mg lisinopril and 12.5 mg hydrochlorothiazide fixed dose formulation in 18 healthy Indian volunteers. | Jaivik V.Shah Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 5 |
| 4 | The role of cofilin in age-related neuroinflammation显示文摘Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain unclear.The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment.This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly.In this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during neuroinflammation.We also discuss other factors contributing to brain aging and neuroinflammation. | Amsha S.Alsegiani Zahoor A.Shah | 2020 | Neural Regeneration Research2020，15，8： | 3 |
| 5 | Application of an LC–MS/MS method for the analysis of amlodipine,valsartan and hydrochlorothiazide in polypill for a bioequivalence study显示文摘A sensitive and selective method has been proposed for the simultaneous determination of amlodipine(AML),valsartan(VAL) and hydrochlorothiazide(HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry(LC–MS/MS). The analytes and their deuterated analogs were quantitatively extracted from100 μL human plasma by solid phase extraction on Oasis HLB cartridges. The chromatographic separation of the analytes was achieved on a Chromolith RP18 e(100 mm × 4.6 mm) analytical column within 2.5 min. The resolution factor between AML and VAL, AML and HCTZ, and VAL and HCTZ was 2.9, 1.5 and 1.4, respectively,under isocratic conditions. The method was validated over a dynamic concentration range of 0.02–20.0 ng/m L for AML, 5.00–10,000 ng/m L for VAL and 0.20–200 ng/m L for HCTZ. Ion-suppression/enhancement effects were investigated by post-column infusion technique. The mean IS-normalized matrix factors for AML, VAL and HCTZ were 0.992, 0.994 and 0.998, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was ≤ 5.56% and the recovery was in the range of 93.4%–99.6% for all the analytes. The method was successfully applied to a bioequivalence study of 5 mg AML + 160 mg VAL + 12.5 mg HCTZ tablet formulation(test and reference) in 18 healthy Indian males under fasting. The mean log-transformed ratios of C max, AUC0–120 h and AUC0-inf and their 90% CIs were within 90.2%–102.1%. The assay reproducibility was demonstrated by reanalysis of 90 incurred samples. | Jaivik V.Shah Jignesh M.Parekh Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 3 |
| 6 | Biliary Strictures in 130 Consecutive Right Lobe Living Donor Liver Transplant Recipients: Results of a Western Center显示文摘 | S. A.Shah D. R.Grant I. D.McGilvray P. D.Greig M.Selzner L. B.Lilly N.Girgrah G. A.Levy M. S.Cattral | 2006 | American Journal of Transplantation2006，，1： | 2 |
| 7 | 美国放射学院适宜性标准:肩关节置换术后影像学检查(续)显示文摘过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分。第一部分阐述了对各种影像学检查模式的总体探讨,包括X线片、计算机断层扫描、核磁共振成像、超声、核医学以及它们提供有益的以治疗为导向的信息时所发挥的作用。第二部分重点研究最佳影像学方法的选择,用于肩关节置换术的并发症,包括无菌性松动、感染、骨折、肩袖肌腱撕裂和神经损伤。在本报告中所提供的美国放射学院适宜性标准循证指南,是通过广泛分析来自同行评审期刊的现有医学文献,并应用行之有效的方法学而完成的(兰德/加州大学洛杉矶分校的适宜性方法以及推荐评价、发展和评估分级),它们用于特殊临床情况下的影像学检查和治疗措施的适宜性评价。多学科专家小组对指南进行了进一步的分析和审查。由于用于推荐合适成像算法的数据会出现不足或模棱两可,在这种情况下,专家意见可能对现有证据进行补充。为此,将美国《放射学院适宜性标准:肩关节置换术后影像学检查》翻译成中文,供同道参考。 | 张晓萌 陈建海 Soterios Gyftopoulos Zehava S.Rosenberg Catherine C.Roberts Jenny T.Bencardino Marc Appel Steven J.Baccei R.Carter Cassidy Eric Y.Chang Michael G.Fox Bennett S.Greenspan Mary G.Hochman Jon A.Jacobson Douglas N.Mintz Joel S.Newman Nehal A.Shah Kirstin M.Small Barbara N.Weissman | 2017 | 中华肩肘外科电子杂志2017，5，4： | 2 |
| 8 | 50 years of scanning electron microscopy of bone——a comprehensive overview of the important discoveries made and insights gained into bone material properties in health,disease,and taphonomy显示文摘Bone is an architecturally complex system that constantly undergoes structural and functional optimisation through renewal and repair.The scanning electron microscope (SEM) is among the most frequently used instruments for examining bone.It offers the key advantage of very high spatial resolution coupled with a large depth of field and wide field of view.Interactions between incident electrons and atoms on the sample surface generate backscattered electrons,secondary electrons,and various other signals including X-rays that relay compositional and topographical information.Through selective removal or preservation of specific tissue components (organic,inorganic,cellular,vascular),their individual contribution(s) to the overall functional competence can be elucidated.With few restrictions on sample geometry and a variety of applicable sample-processing routes,a given sample may be conveniently adapted for multiple analytical methods.While a conventional SEM operates at high vacuum conditions that demand clean,dry,and electrically conductive samples,non-conductive materials (e.g.,bone) can be imaged without significant modification from the natural state using an environmental scanning electron microscope.This review highlights important insights gained into bone microstructure and pathophysiology,bone response to implanted biomaterials,elemental analysis,SEM in paleoarchaeology,3D imaging using focused ion beam techniques,correlative microscopy and in situ experiments.The capacity to image seamlessly across multiple length scales within the meso-micro-nano-continuum,the SEM lends itself to many unique and diverse applications,which attest to the versatility and user-friendly nature of this instrument for studying bone.Significant technological developments are anticipated for analysing bone using the SEM. | Furqan A.Shah Krisztina Ruscsák Anders Palmquist | 2019 | Bone Research2019，7，2： | 2 |
| 9 | Determination of lercanidipine in human plasma by an improved UPLC–MS/MS method for a bioequivalence study显示文摘An improved and reliable ultra-performance liquid chromatography/tandem mass spectrometry(UPLC–MS/MS) method has been developed and validated for the determination of lercanidipine in human plasma. Plasma samples with lercanidipine-d3 as an internal standard(IS) were prepared by solid phase extraction on Phenomenex Strata-X cartridges using 100 μL of human plasma. Chromatographic analysis was performed on UPLC BEH C_(18)(50 mm*2.1 mm, 1.7μm) column under isocratic conditions. Linear calibration curves were obtained over a wide dynamic concentration range of 0.010–20.0 ng/mL. Matrix effect was assessed by post-column infusion, post-extraction spiking and standard-line slope methods.The mean extraction recovery was >94% for the analyte and IS. Inter-batch and intra-batch precision(%CV) across five quality controls was <5.8%. Bioequivalence study was performed with 36 healthy subjects after oral administration of 10 mg of lercanidipine and the assay reproducibility was evaluated by reanalysis of 133 incurred samples. | Darshan V.Chaudhary Daxesh P.Patel Priyanka A.Shah Jaivik V.Shah Mallika Sanyal Pranav S.Shrivastav | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 10 | In‐hospital mortality from liver resection for hepatocellular carcinoma显示文摘 | Jessica P.Simons Sing ChauNg Joshua S.Hill Shimul A.Shah Jennifer F.Tseng | 2010 | Cancer2010，，7： | 1 |
| 11 | Anthelmintic, antimicrobial, antioxidant and cytotoxic activity of Caltha palustris var. alba Kashmir, India显示文摘The methanolic extract obtained from the root portion of Caltha palustris var. alba was evaluated for its anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition(WMI) assay and fecal egg count reduction(FECR) assay, respectively. The extract was subjected to antimicrobial activity using agar-well diffusion method against different bacterial strains. In addition the extract was evaluated for cytotoxic and antioxidant activity against cultured THP-1(Leukemia), A-549(Lung), HCT-15(Colon), Cervix(HeLa) and PC-3(Prostrate) cell lines by SRB and DPPH radical scavenging assays. The extract used resulted in mean %WMI of 94.44%, as observed when the worms were put in lukewarm buffer for 30 min after exposure to different treatments. The mean mortality index of the sample was 0.95. The lethal concentration(LC50) was 0.11 mg·mL-1. Cell lines were exposed to concentration of 100 μg·mL-1 of extract for 48 h, which reduced the viability of these cell lines. The same plant extract also showed 55.58% DPPH radical scavenging activity. | Sofi Mubashir Mohd Yousuf Dar Bashir A.Lone M.Iqbal Zargar Wajaht A.Shah | 2014 | Chinese Journal of Natural Medicines2014，12，8： | 1 |
| 12 | Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems显示文摘Intracerebral hemorrhage(ICH)is a subtype of stroke associated with higher rates of mortality.Currently,no effective drug treatment is available for ICH.The molecular pathways following ICH are complicated and diverse.Nucleic acid therapeutics such as gene knockdown by small interfering RNAs(siRNAs)have been developed in recent years to modulate ICH’s destructive pathways and mitigate its outcomes.However,siRNAs delivery to the central nervous system is challenging and faces many roadblocks.Existing barriers to systemic delivery of siRNA limit the use of naked siRNA;therefore,siRNA-vectors developed to protect and deliver these therapies into the specific-target areas of the brain,or cell types seem quite promising.Efficient delivery of siRNA via nanoparticles emerged as a viable and effective alternative therapeutic tool for central nervous system-related diseases.This review discusses the obstacles to siRNA delivery,including the advantages and disadvantages of viral and nonviral vectors.Additionally,we provide a comprehensive overview of recent progress in nanotherapeutics areas,primarily focusing on the delivery system of siRNA for ICH treatment. | Daniyah A.Almarghalani Sai H.S.Boddu Mohammad Ali Akhila Kondaka Devin Ta Rayyan A.Shah Zahoor A.Shah | 2022 | Neural Regeneration Research2022，17，8： | 1 |
| 13 | Some New Inequalities for Wavelet Frames on Local Fields显示文摘Wavelet frames have gained considerable popularity during the past decade,primarily due to their substantiated applications in diverse and widespread fields of science and engineering. Finding general and verifiable conditions which imply that the wavelet systems are wavelet frames is among the core problems in time-frequency analysis. In this article, we establish some new inequalities for wavelet frames on local fields of positive characteristic by means of the Fourier transform. As an application,an improved version of the Li-Jiang inequality for wavelet frames on local fields is obtained. | Firdous A.Shah Owais Ahmad Neyaz A.Sheikh | 2017 | Analysis in Theory and Applications2017，33，2： | 1 |
| 14 | Invasion by Conyza sumatrensis alters soil microbial community structure in urban ecosystems显示文摘Introduction:Whether invasive plants stimulate or inhibit the soil microbial diversity is still an open question.Despite large-scale invasion by Conyza sumatrensis(Retz.)E.Walker in the urban ecosystems of the Srinagar city of the Kashmir Himalayan region,limited information exists on its impact,particularly,on the belowground microbial diversity.The present study was thus conducted to compare the soil microbial(bacterial and ascomycetous fungal)diversity between the sites invaded by C.sumatrensis and un-invaded(control)sites.Methods:Soil metagenome was extracted from C.sumatrensis invaded and un-invaded plots at the three study sites.A total of six plots(5×5 m each in size),including three invaded by C.sumatrensis and three un-invaded plots were nested within each study site.DNA after amplification was subject to denaturing gradient gel electrophoresis(DGGE);the bands were extracted from the DGGE gel,re-amplified,and sequenced for identification of the species.Results:The number of bacterial species was reduced in the invaded plots at two out of the three sites while as it was relatively higher in the un-invaded plots with many species exclusively found in these plots.Fungal species richness was higher in the invaded plots compared to the un-invaded plots at all the three sites.Also,more fungal species were found to occur exclusively in the invaded plots without being represented in the un-invaded plots.Conclusions:Invasion by C.sumatrensis alters soil microbial community structure in the urban ecosystems in the Kashmir Himalaya.How this species does so and what benefits does it draw from such alteration promise to be an interesting future discourse. | Nazima Rasool Zafar A.Reshi Damase P.Khasa Mudasir Roshan Manzoor A.Shah | 2016 | Ecological Processes2016，5，1： | 1 |
| 15 | Predicting plant invasiveness from native range size: clues from the Kashmir Himalaya显示文摘Aims In view of the growing interest in modelling the potential spread of invasive species,prediction of plant invasiveness on the basis of native range size holds considerable promise.Our objective was to use a simple model to evaluate whether a wider native range predisposes plant species to become invasive in non-native regions and to easily identify potential invaders on this basis.The Kashmir Himalayan alien flora,of which a large proportion is native to Europe,was used to test this model.Methods The Kashmir Himalayan alien flora comprises 436 species of vascular plants at different stages of invasion.We focussed on plant species at two critical invasion stages(sensu Colautti and MacIsaac 2004),i.e.Stage II(species that are just at the earliest phase of introduction)and Stage V(species that are widespread and dominant in the invaded region and are thus considered invasive).We used the territorial distribution in Europe(number of countries)as a surrogate for the native range size of plants of European origin.Important Findings Using a subset of 88 species,for which information on the native European range was available,we showed that a large proportion(68%)of Stage II species growing in the Kashmir Valley had a relatively restricted European range(present in<20 countries);on the other hand,77%of Stage V species had an extensive native range(present in>20 countries).We consequently hypothesized that 14 Kashmir Himalayan Stage II species of European origin that are distributed in>20 European countries are at risk of becoming future invaders in Kashmir.On the other hand,those Kashmir Himalayan Stage II species of European origin distributed in<20 European countries are less likely to become invasive.Although this analysis is quite simple,the data suggest that a wider native range is a good predictor of plant invasiveness and could be used as a simple and low-cost early warning tool in predicting potential invasive species. | Manzoor A.Shah Zafar A.Reshi Claude Lavoie | 2012 | Journal of Plant Ecology2012，5，2： | 1 |
| 16 | In‐hospital mortality from liver resection for hepatocellular carcinoma显示文摘 | Jessica P.Simons Sing ChauNg Joshua S.Hill Shimul A.Shah Jennifer F.Tseng | 2010 | Cancer2010，，7： | 1 |
| 17 | Repair and regeneration properties of Ginkgo biloba after ischemic brain injury显示文摘The irretrievable fate of neurons dominated the neuroscience rhetoric for the first half of this century,a position that was fiercely contested and recently debunked by extensive studies carried out in the field of neuroregeneration research.The turning point came in the year 1928,when Ramon Y.Cajal’s(Lobato,2008)work suggested that the regenerative capacity | Aparna Raghavan Zahoor A.Shah | 2014 | Neural Regeneration Research2014，9，11： | 1 |
| 18 | Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry显示文摘A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography–tandem mass spectrometry(LC–MS/MS) was developed for the simultaneous determination of amiloride(AMI) and hydrochlorothiazide(HCTZ) in human plasma. Sample clean-up with 250 μL of plasma was done on Phenomenex Strata^(?)-X extraction cartridges using their labeled internal standards(AMI-15 N3 and HCTZ-13 C,d2). Chromatography was performed on Hypersil Gold C18(50 mm×3.0 mm, 5 μm) column using acetonitrile with 4.0 m M ammonium formate(p H 4.0, adjusted with 0.1% formic acid)(80:20, v/v) as the mobile phase. Detection was carried out on a triple quadrupole API 5500 mass spectrometer utilizing an electrospray ionization interface and operating in the positive ionization mode for AMI and negative ionization mode for HCTZ. Multiple reaction monitoring was used following the transitions at m/z 230.6/116.0, m/z233.6/116.0, m/z 296.0/204.9 and m/z 299.0/205.9 for AMI, AMI-15 N3, HCTZ and HCTZ-13 C,d2,respectively. Calibration curves were linear(r2≥0.9997) over the concentration range of 0.050–50.0 and0.50–500 ng/m L for AMI and HCTZ, respectively, with acceptable accuracy and precision. The signal-to-noise ratio at the limit of quantitation was ≥14 for both the analytes. The mean recovery of AMI and HCTZ from plasma was 89.0% and 98.7%, respectively. The IS-normalized matrix factors determined for matrix effect ranged from 0.971 to 1.024 for both the analytes. The validated LC–MS/MS method was successfully applied to a bioequivalence study using 5 mg AMI and 50 mg HCTZ fixed dose tablet formulation in 18 healthy Indian volunteers with good reproducibility. | Jaivik V.Shah Priyanka A.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 1 |
| 19 | SPE-UPLC-MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women显示文摘A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method is described for determination of letrozole in human plasma.Following solid phase extraction(SPE) of letrozole and letrozole-d4 on Orochem DVB-LP cartridges,chromatography was performed on Acquity UPLC BEH C_(18)(50 mm × 2.1 mm.1.7 μm) column using methanol-0.1%formic acid in water(85:15,v/v) as the mobile phase.Detection was carried out on a triple quadrupole mass spectrometer with an electrospray source,operated under positive ionization mode.Quantitation of letrozole and letrozole-d4 was done using multiple reaction monitoring(MRM) following the transitions at m/z286.2→217.0 and m/z 290.2→221.0,respectively.The calibration plots were linear through the concentration range of 0.10-100 ng/mL(r^2 ≥ 0.9990) using 100 μL human plasma.The extraction recovery of letrozole ranged from 94.3%to 96.2%and the intra-batch and inter-batch precision was ≤ 5.2%.The method was successfully applied to a bioequivalence study of letrozole after oral administration of2.5 mg tablet formulation to 16 healthy postmenopausal Indian women.The assay reproducibility was also established through incurred sample reanalysis(ISR) of 74 subject samples. | Pravin G.Vanol Puran Singhal Priyanka A.Shah Jaivik V.Shah Pranav S.Shrivastav Mallika Sanyal | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 1 |
| 20 | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline显示文摘Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders.Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases.Maintaining a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic diseases.Understanding the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic conditions.This review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging. | Amsha S.Alsegiani Zahoor A.Shah | 2022 | Neural Regeneration Research2022，17，11： | 1 |
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