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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 4 | Molecular dynamics simulations of consolidation processes during fabrication of nanophase palladium显示文摘 | Liu C L Adams J B Siegal R W | 1994 | Nanostructured Materials1994，4，4： | 1 |
| 5 | Transient homodynamic effect of recruitment maneuvers in three experimental models of acute lung injury显示文摘 | Lin S C Adams A B Sinonson D A | 2004 | Crit Care Med2004，32，12： | 1 |
| 6 | Occurrence of glutathione in bacteria显示文摘 | Fahey R C Brown W C Adams W B | 1978 | Journal of Bacteriology1978，133，3： | 1 |
| 7 | Process configurations adapted to membrane bioreactors for enhanced biological phosphorus and nit rogen removal 显示文摘 | L ESJ FAN B GNIRSS R ADAM C | 2002 | Desalination2002，149，： | 1 |
| 8 | A vibration technique for non - destructive assessing the integrity of structures显示文摘 | Cawley P Pye C J Stone B J | 1978 | Journal of Mechanical Engineering Science1978，20，： | 1 |
| 9 | A variable force binder for a draw press显示文摘 | Zhang S L Karl B O | 1998 | Journal of Materials Processing Technology1998，73，： | 1 |
| 10 | Ca Cu3Ti4O12:One-step internal barrier layer capacitor显示文摘 | Sinclair D C Adams T B Morrison F D | 2002 | Applied Physics Letters2002，80，12： | 1 |
| 11 | Understanding precision ni- trogen stress to optimize the growth and lipid content tradeoff in ole- aginous green microalgae 显示文摘 | Adams C Godfrey V Wahlen B | 2013 | Bioresource Technology2013，131，： | 1 |
| 12 | Hydrogen electrosorption into Pd-Cd nanostruetures显示文摘 | ADAMS B D OSTROM C K CHEN A C | 2010 | Langmuir2010，26，10： | 1 |
| 13 | Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes 显示文摘 | Riechmann J L Heard J Martin G Reuber L Jiang C Keddie J Adam L Pineda O Ratcliffe O J Samaha R R Creelman R Pilgrim M Broun P Zhang J Z Ghandehari D Sherman B K Yu G | 2000 | Science2000，290，： | 1 |
| 14 | Developing sustainability criteria for urban infrastructure systems 显示文摘 | Sahely H R Kennedy C A Adams B I | 2005 | Canadian Journal of Civil Engineering2005，32，1： | 1 |
| 15 | Host immune response deter- mines visceral hypeialgesia in a rat model of post-inflammatory irrt- able bowel syndrome 显示文摘 | Adam B Tsopelas C Liebregts T | 2013 | J Gastroenterol2013，11，6： | 1 |
| 16 | Esmolol prevents movement and attenuates the BIS response to orotracheal intubation显示文摘 | MENIGAUX C GUIGNARD B ADAM F | 2002 | Br J Anaesthesia2002，89，6： | 1 |
| 17 | 显示文摘 | Proell W A Adams C E Shoemaker B H | 1948 | Ind Eng Chem1948，40，： | 1 |
| 18 | High-performance Pd-based hydrogen spillover catalysts for hydrogen storage显示文摘 | Adams B D Ostrom C K Chen S | 2010 | J Phys Chem C2010，114，19： | 1 |
| 19 | Guidelines for the primary prevention of stroke a guideline for heahhcare pro- fessionals from the American heart association/American stroke association显示文摘 | Goldstein L B Bushnell C D Adams R J | 2011 | Stroke2011，42，2： | 1 |
| 20 | Cost effective and advanced phosphorus removal in membrane bioreactors for a decentralised wastewater technology 显示文摘 | Gnirss R Lesjean B Adam C | 2003 | Water Sci Technol2003，47，12： | 1 |
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