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| 1 | Active power regulation of wind power systems through demand response显示文摘With the specific characteristics of low-carbon intensity and economy,wind power has been widely promoted around the world.Due to the variable and intermittent nature of wind power production,the system has to frequently redispatch generators in order to ensure the effective use of wind power whilst maintaining system security.In this way,traditional generation costs are increased and the social benefit of wind power decreases indirectly.In this paper,a new regulation strategy based on power flow tracing was proposed,taking advantage of a comfort-constrained demand response strategy to follow the fluctuations of wind farm output,with the remaining imbalance of active power compensated by traditional generators.Examples showed that compared with conventional regulation,demand response could reduce the gross operating costs of the system,and the rapid response could help maintaining system stability in case of contingency.The strategy in this paper also applies to other large-scale integration problems associated with renewable energy resources which display short-term production variability. | MIAO WeiWei JIA HongJie WANG Dan PARKINSON Simon CRAWFORD Curran DJILALI Ned | 2012 | Science China(Technological Sciences)2012，55，6： | 24 |
| 2 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 3 | Mouse embryos cloned from brain tumors显示文摘Cancer cells escape from growth cont rol by accumulating genetic and epig enetic alterations.In rare instances,epigenetic changes alone are oncogenic.Furthermore,a gents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations.How ever,it is unclear to what extent epi genetic reprogramming can reverse o ncogenesis.Using somatic nuclear transfer,we show that medul loblastomas arising in Ptc1+/-mice can direct preimplantation develop ment.Additionally,blastocysts derived from medullobl astoma nuclei form postimplantatio n embryos with typical cell layers.T hus,tumor cells can be epigenetically reprogrammed into n ormal cell types.This approach coul d lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis. | Li L Connelly MC Wetmore C Curran T Morgan JI | 2003 | 癌症2003，22，7： | 11 |
| 4 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 5 | Piezoelectric and piezomagnetic materials and their function in transducer显示文摘 | Berlincourt DA Curran DR Jaffe H | 1964 | Physical Acoustics1964，，： | 7 |
| 6 | Visible-Light-Induced Radical Cascade Cyclization: Synthesis of(20S)-Camptothecin, SN-38 and Irinotecan显示文摘(20S)-Camptothecin, irinotecan and SN-38 were successfully synthesized by a photocatalyzed radical cascade cyclization from an N-propargyliodopyridinone and an arylisonitrile under visible light with a ruthenium catalyst. This synthetic method provided a useful entry into composing campto-thecin family of antitumor agents in good yields under mild reaction conditions without the use of heavy metal reagents. | Yao Yuan Wuheng Dong Xiaoshuang Gao Xiaomin Xie Dennis P. Curran Zhaoguo Zhang | 2018 | Chinese Journal of Chemistry2018，36，11： | 6 |
| 7 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 8 | Emergency resection surgery for colorectal cancer: Patterns of recurrent disease and survival显示文摘AIM To evaluate prognostic pathological factors associated with early metachronous disease and adverse longterm survival in these patients.METHODS Clinical and histological features were analysed retrospectively over an eight-year period for prognostic impact on recurrent disease and overall survival in patients undergoing curative resection of a primary colorectal cancer. RESULTS A total of 266 patients underwent curative surgery during the study period. The median age of the study cohort was 68 year(range 26 to 91) with a followup of 7.9 years(range 4.6 to 12.6). Resection was undertaken electively in 225(84.6%) patients and emergency resection in 35(13.2%). Data on timing of surgery was missing in 6 patients. Recurrence was noted in 67(25.2%) during the study period and was predominantly early within 3 years(82.1%) and involved hepatic metastasis in 73.1%. Emergency resection(OR = 3.60, P = 0.001), T4 stage(OR = 4.33, P < 0.001) and lymphovascular invasion(LVI) (OR = 2.37, P = 0.032) were associated with higher risk of recurrent disease. Emergency resection, T4 disease and a high lymph node ratio(LNR) were strong independent predictors of adverse long-term survival. CONCLUSION Emergency surgery is associated with adverse disease free and long-term survival. T4 disease, LVI and LNR provide strong independent predictive value of longterm outcome and can inform surveillance strategies to improve outcomes. | Joe Littlechild Muneer Junejo Anne-Marie Simons Finlay Curran Darren Subar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，1： | 5 |
| 9 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 10 | Primary malignant lymphoma of the glans penis: a rare :ase report and review of the literature显示文摘 | Li Chu Wei Mao Kim Curran Vikramsingh Xi Liu Hui-Min Qiu jun-Hua Zheng Yi Wang Gen-Pei Yu Qing Xu | 2013 | Asian Journal of Andrology2013，15，4： | 4 |
| 11 | 沿海和海洋生态系统与人类人口系统间的相互作用:关于消费如何调解这种相互作用的看法显示文摘人口、环境及可持续发展的困境 20世纪的80和90年代,环境工作者和普通公众普遍认为,不加控制的人口增长是造成各类环境退化的根本原因。这种新马尔萨斯人口论的观点最初出现在20世纪60年代Ehrlich所著的《人口炸弹》的文章中,该文以危言耸听的语气解释了那十年空前高的人口增长率。在随后的几年中,这种观点,连同关于承载能力的工作以及不断发展的环境运动,导致产生一种表面上看起来是通情达理的结论,即:人口的高增长率,特别是高出生率,对环境有破坏作用。这种夸张的语言往往是无法控制的(见20世纪90年代世界观察研究所的各种出版物),并已扩散到超出学术界和非政府组织部门的范围。 | Sara Curran Anuradha Kumar Wolfgang Lutz Meryl Williams 林宝法 | 2002 | AMBIO-人类环境杂志2002，31，4： | 3 |
| 12 | The MERIS terrestrial chlorophyll index显示文摘 | J. Dash P. J. Curran | 2004 | International Journal of Remote Sensing2004，，23： | 3 |
| 13 | Engineered polyketides:Synergy between protein and host level engineering显示文摘Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical functionalities.Polyketides encompass one of the largest classes of chemically diverse natural products.With thousands of known polyketides,modular polyketide synthases(PKSs)share a particularly attractive biosynthetic logic for generating chemical diversity.The engineering of modular PKSs could open access to the deliberate production of both existing and novel compounds.In this review,we discuss PKS engineering efforts applied at both the protein and cellular level for the generation of a diverse range of chemical structures,and we examine future applications of PKSs in the production of medicines,fuels and other industrially relevant chemicals. | Jesus F.Barajas Jacquelyn M.Blake-Hedges Constance B.Bailey Samuel Curran Jay.D.Keasling | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 3 |
| 14 | MicroRNA-21 and PDCD4 expression in colorectal cancer显示文摘 | K.H. Chang N. Miller E.A.H. Kheirelseid H. Ingoldsby E. Hennessy C.E. Curran S. Curran M.J. Smith M. Regan O.J. McAnena M.J. Kerin | 2011 | European Journal of Surgical Oncology2011，，7： | 3 |
| 15 | Immunochmistry of the Extracellular Matrix显示文摘 | PESEIOTTA D M CURRAN S OISEN B R | 1982 | Bio Res1982，1，： | 2 |
| 16 | A Comprehensive Modeling Study of n -Heptane Oxidation显示文摘 | H.J. Curran P. Gaffuri W.J. Pitz C.K. Westbrook | 1998 | Combustion and Flame1998，，1： | 2 |
| 17 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 18 | Crystal structure of a TAF1-TAF7 complex in human transcription factor liD reveals a promoter binding module显示文摘 | Hui Wang Elizabeth C Curran Thomas R Hinds Edith H Wang Ning Zheng | 2014 | Cell Research2014，24，12： | 2 |
| 19 | Fuzzy cluster algorithm for the automatic identification of joint sets显示文摘 | R.E. Hammah J.H. Curran | 1998 | International Journal of Rock Mechanics and Mining Sciences1998，，7： | 2 |
| 20 | Adherence to treatment guidelines in the pharmacological management of chronic heart failure in an Australian population显示文摘背景将记录长期的心失败(CHF ) 的 pharmacotherapy 并且在澳大利亚的人口评估坚持到治疗指南。方法 677 个病人的药理学管理(女性 46.7% , 75.5 +/- 11.6 年) 与 CHF 回顾地被分析。结果血管收缩素变换的使用酶(王牌) 禁止者 / 血管收缩素受体 blockers (ARB ) 和 -blockers 分别地是 58.2% 和 34.7% 。为王牌 inhibitors/ARBs 的弃权的主要原因是 hyperkalemia 并且提高了浆液 creatinine 水平。为没收到 -blockers, 的病人,气喘和长期的妨碍的肺的疾病是主要禁止徵候。在为王牌 inhibitors/ARBs 和 -blockers 的以上目标剂量的治疗为每药是低的(40.3% 和 28.9% ,分别地) 。为心失败的结论基于证据的医药治疗在下面在一张农村耐心的人口使用。进一步的研究被要求开发过程改进心失败药的最佳的使用。 | Dao-Kuo Yao Le-Xin Wang Shane Curran Patrick Ball | 2011 | Journal of Geriatric Cardiology2011，8，2： | 2 |
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