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| 1 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Bee Parasitic Mite Syndrome(II):The Role of Varroa Mite and Virues 显示文摘 | Hung A C F Adams J R Shimanuki H | 1995 | American Bee Journal1995，12，： | 2 |
| 5 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 6 | Surrogate end points in heart failure 显示文摘 | LEC C R ADAMS K F PATTERSON J H | 2002 | Ann Pharmacother2002，36，3： | 1 |
| 7 | Measurements of acute cerebral infarction: a clinical examination scale 显示文摘 | Brott T Adams H P Jr Olinger C P | 1989 | Stroke1989，20，7： | 1 |
| 8 | Postoperative pain management in orthopaedic patients: no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 9 | Effect of timing of diammonium phosphate addition to fermenting grape must on the production of ethyl carbamate in wine显示文摘 | Adams C Van Vuuren H J J | 2010 | Am J Enol Viticuh2010，61，1： | 1 |
| 10 | Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment(TOAST)显示文摘 | ADAMS H P J R DAVIS P H LEIRA E C | 1999 | Neurology1999，53，1： | 1 |
| 11 | A Coarse/Fine Search PN Code Acquisition Scheme显示文摘 | Adam C V Ronald D W Maximo H S | 2001 | IEEE Transactions on Aerospace and Electronic Systems2001，37，1： | 1 |
| 12 | A simple sulfuric acid pretreatment method to improve the adsorption of Cr(Ⅵ)by chitosan显示文摘 | Lasko C L Adams K H Debenedet E M | | 0，，： | 1 |
| 13 | Security-related comments regarding McEliece's public-key cryptosystem显示文摘 | ADAMS C M MEIJER H | 1989 | IEEE Transactions on Infor- marion Theory1989，35，2： | 1 |
| 14 | Developing sustainability criteria for urban infrastructure systems 显示文摘 | Sahely H R Kennedy C A Adams B I | 2005 | Canadian Journal of Civil Engineering2005，32，1： | 1 |
| 15 | Relations between the photoluminescence efficiency of CdTe nanocrystals and their surface properties revealed by synchrotron XPS显示文摘 | BORCHERT H TALAPIN D V GAPONIK N MCGINLEY C ADAM S LOBO A MOLLER T WELLER H | 2003 | J Phys Chem B2003，107，36： | 1 |
| 16 | Develop- ment and validation of a screening tool to identify eating disor- ders in female athletes显示文摘 | MCNULTY K Y ADAMS C H ANDERSON J M | 2001 | J Am Diet Assoc2001，101，： | 1 |
| 17 | 显示文摘 | Proell W A Adams C E Shoemaker B H | 1948 | Ind Eng Chem1948，40，： | 1 |
| 18 | Postoperative pain management in orthopaedic patients:no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 19 | Raman Cooling of Atoms in an Optical Dipole Trap 显示文摘 | LEE H J ADAMS C S KASEVICH M | 1996 | Phys Rev Lett1996，76，15： | 1 |
| 20 | Mechanisms of immune-mediated liver injury显示文摘 | Adams DH Ju C Ramaiah SK Uetrecht J Jaeschke H | 2010 | Toxicol Sci2010，115，2： | 1 |
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