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| 1 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 2 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 3 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | 显示文摘 | Ju H Y Kwon C Li Q | 1995 | Appl Phys Rev Lett1995，75，： | 2 |
| 5 | Giant magnetoresistance in La1-xSrxMnOz films near room temperature显示文摘 | Ju H L Kwon C Qi Li | 1994 | Appl Phys Lett1994，65，： | 2 |
| 6 | Molecular cloning, expression and phylogenetic analyses of parvalbumin in tilapia, Oreochromis mossambicus显示文摘 | Lee S J Ju C C Chu S L | 2007 | J Exp Zool2007，307，1： | 1 |
| 7 | Nucleic acid biosensor for detection of hepatitis B virus using 2,9-dimethyl- 1,10-phenanthroline copper complex as electrochemical indicator显示文摘 | Li X Ju H Ding C | 2007 | Analytica ChimicaActa2007，582，1： | 1 |
| 8 | 显示文摘 | Ding S J Ju C P Lin J H C | 2000 | Journal of Materials Science:Materials in Medicine2000，11，1： | 1 |
| 9 | Gaussian Mixture Discriminant Analysis and Sub-pixel Land Cover Characterization in Remote Sensing 显示文摘 | JU J C KOLACZYK E D GOPAL S | 2003 | Remote Sensing Environment2003，84，： | 1 |
| 10 | Giant magnetoresistance in La1-xSrxMnO2 films near room temperature 显示文摘 | JU H L K WON C LI Q GREENE R L VENKATESAN T | 1994 | Appl Phys Lett1994，65，16： | 1 |
| 11 | A process for synthesizing high purity monoglycerid 显示文摘 | YANG Y C VALI S R JU Y J | 2003 | Chin Inst Chem Engrs2003，34，6： | 1 |
| 12 | Solvent extraction ofstrontium nitrate by a crown ether using room temperatureionic liquids 显示文摘 | DAI S JU Y H BARNES C E | 1999 | J Chem Soc Dalton Trans1999，8，： | 1 |
| 13 | Nitrogen balance and groundwater nitrate contamination: Comparison among three intensive cropping systems on the North China Plain 显示文摘 | Ju X T Kou C L Zhang F S | 2006 | Environmental Pollution2006，143，1： | 1 |
| 14 | Pulsating and Hydrodynamic Instabilities at Large Lewis Numbers 显示文摘 | Yuan J Ju Y Law C K | 2006 | Combustion and Flame2006，4，： | 1 |
| 15 | Sturcture damage diagnosis using neural network and feature fusion 显示文摘 | Liu Y Y Ju Y F Duan C D | 2011 | Engineering Applications of Artificial Intelli- gence2011，24，1： | 1 |
| 16 | A microfluidie approach to fabricate monodJsperse hollow or porous poly (HEMA - MMA) microspheres using single emulsions as templates 显示文摘 | Zhang H Ju X J Cheng C J | 2009 | J Colloid Interf Sci2009，336，： | 1 |
| 17 | Managing lower extremity muscle tone and function in children with cerebral palsy via eight- week repetitivepassive knee movement intervention 显示文摘 | Cheng H Y Ju Y Y Chen C L | 2013 | Res Dev Disabil2013，34，1： | 1 |
| 18 | A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption显示文摘 | Meng T Xie R Chen Y C Cheng C J Li P F Ju X J Chu L Y | 2010 | Journal of Membrane Science2010，349，12： | 1 |
| 19 | Coupled hydrodynamicand diffusional-thermal instabilities in flame propaga-tion at subunity Lewis numbers显示文摘 | YUAN J JU Y LAW C K | 2005 | Physics of Fluids2005，17，07： | 1 |
| 20 | 显示文摘 | Ju H L Kwon C Li Qi | 1994 | Appl Phys Lett1994，65，： | 1 |
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