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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 5 | Porous silicon bulk micromachining for thermally isolated membrane formation 显示文摘 | Ducs6 Cs Vazsonyi E Adam M | 1997 | Sens Actuat1997，60，13： | 2 |
| 6 | Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection显示文摘 | Adams LA Bulsara M Rossi E | 2005 | Clin Chem2005，51，10： | 1 |
| 7 | The sequence of the human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，： | 1 |
| 8 | Condensed tannin biosynthesis genes are regulated separately from other flavonoid biosynthesis genes in apple fruit skin显示文摘 | Adam M T Benjamin E U Robinson S P | 2006 | Plant Science2006，170，： | 1 |
| 9 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 10 | Endocan or endothelial cell specific molecule-1 (ESM-1):a potential novel endothelial cell marker and a new target for cancer therapy显示文摘 | Sarrazin S Adam E Lyon M | 2006 | Biochim Biophys Acta2006，1765，1： | 1 |
| 11 | Assessing liver fi- brosis with serum marker models显示文摘 | Rossi E Adams LA Bulsara M | 2007 | Clin Biochem Rev2007，28，： | 1 |
| 12 | Endocan or endothelial cell specific molecule-1 -(ESM-1):a potential novel endothelial cell marker and a new target for cancer therapy显示文摘 | Sarrazin S Adam E Lyon M | | 0，，01： | 1 |
| 13 | Use of a whole genome approach to identify vaccine molecules affording protection against topneumococcal bacteremia infection显示文摘 | Wizemann T M Heinrichs J H Adamou J E | | 0，，03： | 1 |
| 14 | Hepascore:an accurate validated predictor of liver fibrosis in chronic hepatitis C infection显示文摘 | Adams LA Bulsara M Rossi E | 2005 | Clinical Chemistry2005，51，10： | 1 |
| 15 | Dietary restriction reduces the rate of estradiol clearance in sheep 显示文摘 | Requist B J Adams T E Adams B M | 2010 | J Anim Sci2010，86，： | 1 |
| 16 | Assessing operations management from a strategic perspective显示文摘 | Adam E E Swamidass P M | 1989 | Journal of Management1989，15，2： | 1 |
| 17 | The sequence of human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，5507： | 1 |
| 18 | Assessing liver fibrosis with serum marker models显示文摘 | Rossi E Adams LA Bulsara M | | 0，，： | 1 |
| 19 | ACC/AHA2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction显示文摘 | Anderson J L Adams C D Antman E M | 2007 | Journal of the American College of Cardiology2007，50，7： | 1 |
| 20 | Variability in root production, phenology, and turnover rate among 12 temperate tree species 显示文摘 | MCCORMACK M L ADAMS T S SMITHWICK E A | 2014 | Ecology2014，95，8： | 1 |
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