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| 1 | Current management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer worldwide and leading cause of death among patients with cirrhosis.Treatment guidelines are based according to the Barcelona Clinic Liver Cancer staging system.The choice among therapeutic options that include liver resection,liver transplantation,locoregional,and systemic treatments must be individualized for each patient.The aim of this paper is to review the outcomes that can be achieved in the treatment of HCC with the heterogeneous therapeutic options currently available in clinical practice. | Parissa Tabrizian Sasan Roayaie Myron E Schwartz | 2014 | World Journal of Gastroenterology2014，20，30： | 18 |
| 2 | 中国艾滋病综合防治政策发展及影响因素分析显示文摘在艾滋病的防治过程中,无论是联合国(UN)、世界卫生组织(WHO),以及发达和发展中国家,防治政策一直是处于不断的争论、修改、完善的过程,这也是政策的特性所决定[1].自1985年我国发现首例艾滋病病例以来,我国的艾滋病防治政策也在不断地发展和完善.为了进一步了解我国艾滋病政策的发展,以及影响政策制定和实施的主要因素,为今后的防治政策的制定提供建议,本文对我国艾滋病流行不同阶段中政策的发展及可能的影响因素进行分析.依据政策的概念及内容[2,3],本次研究选取政策的标准为与艾滋病防治有关的国家级法律、法规及有关部委颁布的文件中涉及艾滋病或与艾滋病有关的预防、治疗与关怀等内容.为描述方便将本研究中所涉及到的法律、行政法规和有关部委文件统称为'政策文件'.本次研究收集的'政策文件'时间范畴为1984-2005年3月,所收集与艾滋病防治相关国家级的'政策文件'的总数为217件. | 颜江瑛 陈秋兰 马彦民 索罗丹 Myron Cohen | 2005 | 中华流行病学杂志2005，26，11： | 14 |
| 3 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 4 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 5 | Assessing the impact of arthropod natural enemies on crop pests at the field scale显示文摘有许多原因,我们发现方法保存,是重要的,并且更好利用无脊椎的庄稼害虫的生来的敌人。当前,生来的敌人影响的措施很少被合并到声称检验害虫控制的研究。大多数研究检验害虫和生来的敌人存在或丰富然后品质上推断影响。当这提供有用数据探讨生态的问题的一个范围时,影响的一项措施为指导害虫管理决策是批评的。经常,一些很简单的技术能被用来获得生来的敌人影响的估计。我们使用了笼子,限制生来的敌人或猎物运动的障碍,生来的敌人攻击的直接观察,和哨兵的基于地的研究的现在的例子估计的猎物项目死亡。在每研究使用的生来的敌人影响的措施需要被定制到农民和他们面对的特定的害虫问题的需要。例如,归因于生来的敌人的死亡的大小可能不比预定和在季节之间的那死亡的一致性重要。定制影响评价将导致简单地不提供怎么保存生来的敌人,但是怎么把这些生来的敌人用作决策的不可分的部分的一般信息的研究结果。 | Sarina Macfadyen Andrew P. Davies Myron P. Zalucki | 2015 | Insect Science2015，22，1： | 7 |
| 6 | 海上执法显示文摘在美国,海上执法权由美国海岸警卫队行使。美国海岸警卫队过去隶属于交通部,由于恐怖主义的威胁及海岸警卫队所承担的重要职责,现已转入国土安全部。今天演讲的内容包括:司法管辖权和职权、紧追权、靠近并登船检查、登船的程序、各个机构间的合作,最重要的是武力的使用和相关政策。 | Myron Nordquist 卢佳(译) | 2005 | 中国海洋法学评论(中英文版)2005，，1： | 7 |
| 7 | Connecting scales: Achieving in-field pest control from areawide and landscape ecology studies显示文摘Areawide 管理有完成然而,在那里指向害虫的答案的长历史是节肢动物天赋敌人的 areawide 管理的小焦点。显示出在生来的敌人丰富和产地差异之间的一种积极关系的风景生态学研究表明风景依赖者害虫抑制,但是还没有清楚地连接了他们的调查结果到害虫管理或到与要求控制的庄稼联系的害虫的套房。相反焦点经常在单个害虫种类和他们的生来的敌人的模型系统上。我们建议从生来的敌人捕获害虫控制的管理行动可能向前正在来如果:(i) 害虫建筑群和特定的管理行动上的反应和预言者变量焦点的套房;(ii )“the landscape” 的贡献被估计预定和生来的敌人移民并且移民到并且从目标庄稼,以及害虫的数字识别;并且(iii ) 与庄稼发展阶段排列的害虫控制阀值是基准在害虫上测量生来的敌人的影响,接着允许在学习区域之间的比较,和归纳。为了完成害虫控制,我们将需要合并什么从模型害虫和生来的敌人系统的生态的理解被学习了并且与内场害虫管理集成 areawide 风景管理。 | Nancy A. Schellhorn Hazel R. Parry Sarina Macfadyen Yongmo Wang Myron P. Zalucki | 2015 | Insect Science2015，22，1： | 6 |
| 8 | Species Exclusion Between an Invasive and an Indigenous Whitefly on Host Plants with Differential Levels of Suitability显示文摘The whitefly Bemisia tabaci has risen to international prominence since the 1980s due to the rapid spread around the globe by the two species B and Q within this species complex.The invasion of B has often been associated with the displacement of indigenous whiteflies.As the genetic structure of B.tabaci is diverse,more case studies of the competitive relationships between B and indigenous species of the whitefly species complex will help to understand further the mechanisms underlying the invasion of B.We examined the competitive interactions between B and ZHJ2,a widely distributed indigenous whitefly in Asia,on host plants with differential levels of suitability to the two species in the laboratory,and also tested the effect of insecticide application on the competitive relationships.Three species of plants were tested including cotton,a plant showing similar levels of suitability to both species,squash,a plant showing higher suitability to B than to ZHJ2,and kidney bean,a plant showing higher suitability to ZHJ2 than to B.In the case of no insecticide application,B displaced ZHJ2 on cotton,squash,and kidney bean by the 6th,3rd and 10th generation,respectively.With the application of imidacloprid,the displacement of ZHJ2 by B on cotton occurred by the 5th generation.As the displacement progressed,the proportion of B females increased,and the proportion of ZHJ2 females decreased on cotton and squash.In contrast,on kidney bean the proportion of B females remained unchanged while that of ZHJ2 increased.These results show the strong capacity of the invasive B to displace ZHJ2,and indicate that host plants with differential levels of suitability to the two species may affect the speed but not the trend of displacement and insecticide application may accelerate the process of displacement. | LUAN Jun-bo XU Jing LIN Ke-ke Myron P Zalucki LIU Shu-sheng | 2012 | Journal of Integrative Agriculture2012，11，2： | 6 |
| 9 | 差示扫描量热法用于不同类型药物的纯度分析显示文摘本文应用差示扫描量热法对11种不同类型药物的纯度进行了分析测定。着重探讨了实验条件的选择及的限制等技术关键点。 | 张伟 赵明 Myron Rhodes | 1993 | 中国药学杂志1993，28，10： | 5 |
| 10 | 《Science》杂志发表关于计算社会科学的文章:Computational Social Science显示文摘计算科学是一门正在兴起的综合性学科,它依赖于先进的计算机及计算技术对理论科学、大型实验、观测数据、应用科学、国防以及社会科学进行模型化、模拟与仿真、计算等。特别是对极复杂系统进行模型与程序化,然后利用计算机给出严格理论及实验无法达到的过程数据或者直接模拟出整个复杂过程的演变或者预测过程的发展趋势。对基础科学、应用科学、国防科学、社会科学以及工程技术等的发展有着不可估量的科学作用与经济效益。其中,随着信息化和网络化的不断普及与深入,社会动态变化的速度和规模已经提高到一个前所未有的水平,计算科学在社会科学中的深入应用,即计算社会科学也将成为科研信息化发展中一个新的热点。本刊对《Science》2009年2月发表的一篇关于计算社会科学的文章《Computational Social Science》进行了摘编,该文由美国多个大学及研究机构的共15名研究人员共同编写,文章从计算社会科学的数据获取、研究方法及其制约因素,以及人才的培养等几个方面,描述了计算社会科学的发展、讨论了社会科学研究的特点等。其主要目的是想借此文向广大读者介绍计算社会科学这一学科理念,推动这一对于提高社会科学研究水平和规范性的研究方法在国内的发展,并以此进一步繁荣我国社会科学研究工作。 | 张鉴 孔丽华 David Lazer Alex Pentland Lada Adamic Sinan Aral Albert-László Barabási Devon Brewer Nicholas Christakis Noshir Contractor James Fowler Myron Gutmann Tony Jebara Gary King Michael Macy Deb Roy Marshall Van Alstyne | 2010 | 科研信息化技术与应用2010，0，2： | 5 |
| 11 | 肝的周期性的巨大的 hemangiomas : 有文学评论的二个稀罕案例的报告显示文摘 Most hepatic hemangiomas(HHs) are small,asymptomatic and do not require clinical intervention.Surgical resection is only indicated for symptomatic hemangiomas.We report here cases of recurrent HHs in 2 women of 37 and 40 years old,who initially presented with abdominal pain and mass.Radiological examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter,respectively.Surgical liver segmental resections were performed in both,and the diagnosis of cavernous hemangioma was confirmed.Both patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial surgery.In the first patient,a 15 cm recurrent hemangioma was resected,but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe,which was not amendable for resection.In the second patient,a 16 cm hemangioma was seen on radiogram,and because the lesion was not symptomatic,conservative observation was offered.Recurrence after liver resection of giant hemangioma is extremely rare.The pathogenesis of tumor progression and recurrence is unknown,as is the management of these patients with recurrent hemangioma,particularly when it is extensive and unresectable. | Hongfa Zhu Khaled Obeidat Jie Ouyang Sasan Roayaie Myron E Schwartz Swan N Thung | 2012 | World Journal of Gastrointestinal Surgery2012，4，11： | 5 |
| 12 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 13 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 14 | Assessing the impact of natural enemies in agroecosystems: toward "real" IPM or in quest of the Holy Grail?显示文摘 | Myron P. Zalucki Michael J. Furlong Nancy A. Schellhorn Sarina Macfadyen Andrew P. Davies | 2015 | Insect Science2015，22，1： | 4 |
| 15 | Temperature-dependent development of Xyleborus fornicatus (Coleoptera: Scolytidae), the shot-hole borer of tea in Sri Lanka: Implications for distribution and abundance显示文摘Xyleborus fornicatus (Eichh ) 的开发的率上的温度的效果被在经常的温度(15-32 度 C ) 的一个范围下面扶养个人决定。开发的率在大量温度上以一种线性方式变化了。更低的发展阀值的估计为鸡蛋(加或减 0.5 度 C 的 15.7 )被获得,幼虫(加或减 0.8 度 C 的 15.8 )和为开发的度天( DD )是加或减 4.4 的 70 ,加或减加或减 5.1 DD 的 8.5 和 72 的 95 分别地。为开发的最适温度在为所有阶段的 30 度 C 附近。在更凉爽的高国家区域的温度变化(在 1400 m 上面) 与在 15 度附近的平均温度, C 似乎为害虫的发展批评,它可能为在那些区域的害虫的近的缺席负责。在中间的国家区域(600-1200 m ) 的温度变化(18-30 度 C ) 在经常的条件下面与开发相比赞成害虫的发展。因此,越过在斯里兰卡种区域的茶的射击洞 borer 的高度的分发被温度主要管理。 | RAVINDRA SAMPATH WALGAMA MYRON PHILLIP ZALUCKI | 2007 | Insect Science2007，14，4： | 3 |
| 16 | Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis显示文摘 | Sasan Roayaie Jonathan D. Schwartz Max W. Sung Sukru H. Emre Charles M. Miller Gabriel E. Gondolesi Nancy R. Krieger Myron E. Schwartz | 2004 | Liver Transpl2004，，4： | 3 |
| 17 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 18 | Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA显示文摘 | John P. Duffy Andrew Vardanian Elizabeth Benjamin Melissa Watson Douglas G. Farmer Rafik M. Ghobrial Gerald Lipshutz Hasan Yersiz David S. K. Lu Charles Lassman Myron J. Tong Jonathan R. Hiatt Ronald W. Busuttil | 2007 | Annals of Surgery2007，，3： | 3 |
| 19 | Evaluation of different models to describe egg and pupal development of Xyleborus fornicatus Eichh, (Coleoptera: Scolytidae), the shot-hole borer of tea in Sri Lanka显示文摘鸡蛋的发展数据和 Xyleborus fornicatus Eichh 的蛹(翘目:Scolytidae ) ,在斯里兰卡的茶的射击洞 borer,在常数,温度被用来评估一线性并且为昆虫开发的七个非线性的模型。模型评估基于对数据(决心的剩余平方和和系数或非线性的回归的系数) 合适,可测量的参数的数字,在阀值的评价的适合的系数和精确性的生物的值。非线性的模型, Lactin 模型适合试验性的数据很好并且与线性模型一起,能被用来描述这种的 thetemperature 依赖的开发。 | RAVINDRA SAMPATH WALGAMA MYRON PHILLIP ZALUCKI | 2006 | Insect Science2006，13，2： | 3 |
| 20 | Resection and Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Josep Llovet Myron Schwartz Vincenzo Mazzaferro | 2005 | Semin Liver Dis2005，，02： | 3 |
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