|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 2 | Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival. | Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud | 2012 | World Journal of Gastroenterology2012，18，5： | 7 |
| 3 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 4 | Transradial approach for acute stroke intervention: technical procedure and clinical outcomes显示文摘background and purpose Radial artery catheterisation is an alternate route of access that has recently started to gain more widespread use for neuroendovascular procedures,including acute stroke intervention.In this small case series,we present our institution’s outcomes in patients undergoing acute stroke interventions via transradial access.Materials and methods We present a retrospective study of 15 patients who underwent acute stroke intervention via radial artery access.We analyse these patients’periprocedural and clinical outcomes after undergoing mechanical thrombectomy.results A total of 15 consecutive patients were included in the study(9 males and 6 females),and all patients were able to successfully undergo mechanical thrombectomy via radial artery access.The mean time of arterial puncture to reperfusion was 50±28 min(range:15-104).A TICI 2b/3 revascularisation was achieved in 13/15 patients(87%);a TICI 1 and TICI 2a outcome was achieved on the other two patients.One patient incurred an iatrogenic vessel dissection during the procedure.Eight of out 15 patients(53%)had favourable mRS(0-3)at the time of discharge from the hospital.Conclusion Radial artery catheterisation is technically feasible for performing acute stroke interventions with favourable time to revascularisation and good overall clinical outcomes. | Omaditya Khanna Nikolaos Mouchtouris Ahmad Sweid Nohra Chalouhi Ritam Ghosh Fadi Al Saiegh Michael R Gooch Stavropoula Tjoumakaris Robert H Rosenwasser Victor Romo Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 4 |
| 5 | Shellfish allergy and relation to iodinated contrast media: United Kingdom survey显示文摘AIM: To assess current practice of United Kingdom cardiologists with respect to patients with reported shellfish/iodine allergy, and in particular the use of iodinated contrast for elective coronary angiography.Moreover we have reviewed the current evidence-base and guidelines available in this area.METHODS: A questionnaire survey was send to 500senior United Kingdom cardiologists(almost 50% cardiologists registered with British Cardiovascular Society)using email and first 100 responses used to analyze practise. We involved cardiologists performing coronary angiograms routinely both at secondary and tertiary centres. Three specific questions relating to allergy were asked:(1) History of shellfish/iodine allergy in pre-angiography assessment;(2) Treatments offeredfor shellfish/iodine allergy individuals; and(3) Any specific treatment protocol for shellfish/iodine allergy cases. We aimed to establish routine practice in United Kingdom for patients undergoing elective coronary angiography. We also performed comprehensive PubMed search for the available evidence of relationship between shellfish/iodine allergy and contrast media.RESULTS: A total of 100 responses were received, representing 20% of all United Kingdom cardiologists. Ninety-three replies were received from consultant cardiologists, 4 from non-consultant grades and 3 from cardiology specialist nurses. Amongst the respondents, 66% routinely asked about a previous history of shellfish/iodine allergy. Fifty-six percent would pre-treat these patients with steroids and anti-histamines. The other 44% do nothing, or do nonspecific testing based on their personal experience as following:(1) Skin test with 1 mL of subcutaneous contrast before intravenous contrast;(2) Test dose 2 mL contrast before coronary injection;(3) Close observation for shellfish allergy patients; and(4) Minimal evidence that the steroid and anti-histamine regime is effective but it makes us feel better.CONCLUSION: There is no evidence that allergy to shellfish alters the risk of reaction to intravenous contrast more than any other allergy and asking about such allergies in pre-angiogram assessment will not provide any additional information except propagating the myth. | Mudassar Baig Ahmad Farag Jamal Sajid Rahul Potluri R Bruce Irwin Hafiz Mohammed Idrees Khalid | 2014 | World Journal of Cardiology2014，6，3： | 3 |
| 6 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 7 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 8 | Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins显示文摘Testicular cancer seminoma is one of the most common types of cancer among men of reproductive age.Patients with this condition usually present reduced semen quality,even before initiating cancer therapy.However,the underlying mechanisms by which testicular cancer seminoma affects male fertility are largely unknown.The aim of this study was to investigate alterations in the sperm proteome of men with seminoma undergoing sperm banking before starting cancer therapy,in comparison to healthy proven fertile men(control group).A routine semen analysis was conducted before cryopreservation of the samples(n=15 per group).Men with seminoma showed a decrease in sperm motility(P=0.019),total motile count(P=0.001),concentration(P=0.003),and total sperm count(P=0.001).Quantitative proteomic analysis identified 393 differentially expressed proteins between the study groups.Ten proteins involved in spermatogenesis,sperm function,binding of sperm to the oocyte,and fertilization were selected for validation by western blot.We confirmed the underexpression of heat shock-related 70 kDa protein 2(P=0.041),ubiquinol-cytochrome C reductase core protein 2(P=0.026),and testis-specific sodium/potassium-transporting ATPase subunit alpha-4(P=0.016),as well as the overexpression of angiotensin I converting enzyme(P=0.005)in the seminoma group.The altered expression levels of these proteins are associated with spermatogenesis dysfunction,reduced sperm kinematics and motility,failure in capacitation and fertilization.The findings of this study may explain the decrease in the fertilizing ability of men with seminoma before starting cancer therapy. | Tania R Dias Ashok Agarwal Peter N Pushparaj Gulfam Ahmad Rakesh Sharma | 2020 | Asian Journal of Andrology2020，22，1： | 2 |
| 9 | Urea-Induced Unfolding of F Isomer of Human Serum Albumin:A Case Study Using Multiple Probes显示文摘 | KHAN A R H | 2005 | Arch Biochem Biophys2005，437，： | 1 |
| 10 | RAPDanalysis of Fusarium isolates causing Mango Malformation disease inPakistan显示文摘 | ZAFAR I MEHBOOB R ALTAF D AHMAD S YUSUF Z | 2006 | World Journal Microbiology and Biotechnology2006，22，11： | 1 |
| 11 | Shear lag in composite box girders of complex cross section显示文摘 | Evans H R Ahmad M K Kristek V | 1993 | J Constructional Steal Research1993，24，3： | 1 |
| 12 | Primary secondary,and tertiary hyperparathyroidism显示文摘 | Ahmad R Hammond JM | 2004 | Otolaryngol Clin N Am2004，37，4： | 1 |
| 13 | A Composite core conductor for low sag at high temperatures显示文摘 | Ahmad A Eric J B Steven R N | 2005 | IEEE Transactions on Power Delivery2005，20，3： | 1 |
| 14 | Role of silicon in salt tolerance of wheat显示文摘 | Ahmad R Zaheers S H Ismail S | 1992 | Plant Sci1992，85，： | 1 |
| 15 | Relative sensitive of spring wheat grain yield and quality parameters to moisture deficit 显示文摘 | Guttieri M J Ahmad R Stark J C | 2001 | Crop Science2001，41，： | 1 |
| 16 | Apoptosis in fresh and cryopr- eserved Buffalo sperm 显示文摘 | Khan D R Ahmad N Anzar M | 2009 | Theriogenology2009，71，5： | 1 |
| 17 | Fitting of statistical distributions to wind speed data in Malaysia 显示文摘 | Azami Z Ahmad M R | 2009 | European Journal of Scientific Research2009，26，1： | 1 |
| 18 | ERCP core curriculum显示文摘 | Chutkan R K Ahmad A S Cohen J Cruz-Correa M R Desilets D J Dominitz J A ERCP Core Curriculum prepared by the ASGE Training Committee | 2006 | Gastrointest Endosc2006，63，： | 1 |
| 19 | In vitro evolved non-aggregating and thermostable lipase:structural and thermodynamic investigation显示文摘 | Kamal M Z Ahmad S Molugu T R | 2011 | J Mol Biol2011，413，： | 1 |
| 20 | The blue-light receptor cryptochrome 1 shows functional dependence on phytochrome A or phytochrome B in Arabidopsis thaliana显示文摘 | AHMAD M CASHMORE A R | 1997 | Plant J1997，11，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员