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| 1 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 2 | Remote heart rate measurement using low-cost RGB face video: a technical literature review显示文摘 | Philipp V. ROUAST Marc T. P. ADAM Raymond CHIONG David CORNFORTH Ewa LUX | 2018 | Frontiers of Computer Science2018，12，5： | 12 |
| 3 | Evolutionary Optimization: Pitfalls and Booby Traps显示文摘Evolutionary computation (EC), a collective name for a range of metaheuristic black-box optimization algorithms, is one of the fastest-growing areas in computer science. Many manuals and 'how-to's on the use of different EC methods as well as a variety of free or commercial software libraries are widely available nowadays. However, when one of these methods is applied to a real-world task, there can be many pitfalls and booby traps lurking - certain aspects of the optimization problem that may lead to unsatisfactory results even if the algorithm appears to be correctly implemented and executed. These include the convergence issues, ruggedness, deceptiveness, and neutrality in the fitness landscape, epistasis, non-separability, noise leading to the need for robustness, as well as dimensionality and scalability issues, among others. In this article, we systematically discuss these related hindrances and present some possible remedies. The goal is to equip practitioners and researchers alike with a clear picture and understanding of what kind of problems can render EC applications unsuccessful and how to avoid them from the start. | Thomas Weise Raymond Chiong Ke Tang | 2012 | Journal of Computer Science & Technology2012，27，5： | 5 |
| 4 | 重组人骨形态发生蛋合7、转化生长因子β_1对兔脂肪基质细胞体外成骨潜能的初步实验研究显示文摘目的分离兔脂肪基质细胞并诱导培养其成骨表型,为扩增种子细胞提供实验依据。方法获取兔脂肪组织,胶原酶消化得到脂肪基质细胞,进行原代培养,消化传代后诱导培养,设置含重组人骨形态发生蛋白7(rhBMP-7)、转化生长因子β1(TGF-β1)的改良成骨诱导化培养组、常规成骨诱导培养组及对照非成骨诱导培养组,绘制生长曲线并对其成骨表型进行鉴定。结果与常规成骨诱导化方式相比,rhBMP-7、TGF-β1能明显促进的脂肪基质细胞增殖,并促使其向成骨细胞演变,碱性磷酸酶及VonKossa染色强阳性,群体倍增时间为32h;对照组未显示成骨细胞方向分化。结论采用多因子的成骨诱导培养利于脂肪基质细胞的增殖及诱导分化,是扩增组织工程种子细胞的有效方法。 | 郭洪刚 刘静 Yong Soon Chiong 刘海峰 | 2007 | 中国骨与关节损伤杂志2007，22，11： | 4 |
| 5 | Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse显示文摘 | Xiang Jin Kang Chiong Isabella Noelle Caparas Boon Seng Soh Yong Fan | 2017 | Protein & Cell2017，8，11： | 3 |
| 6 | Photon momentum transfer in inhomogeneous dielectric mixtures and induced tractor beams显示文摘The determination of optical force as a consequence of momentum transfer is inevitably subject to the use of the proper momentum density and stress tensor.It is imperative and valuable to consider the intrinsic scheme of photon momentum transfer,particularly when a particle is embedded in a complex dielectric environment.Typically,we consider a particle submerged in an inhomogeneous background composed of different dielectric materials,excluding coherent illumination or hydrodynamic effects.A ray-tracing method is adopted to capture the direct process of momentum transfer from the complex background medium,and this approach is validated using the modified Einstein–Laub method,which uses only the interior fields of the particle in the calculation.In this way,debates regarding the calculation of the force with different stress tensors using exterior fields can be avoided.Our suggested interpretation supports only the Minkowski approach for the optical momentum transfer to the embedded scatterer while rejecting Peierls’s and Abraham’s approaches,though the momentum of a stably moving photon in a continuous background medium should be considered to be of the Abraham type.Our interpretation also provides a novel method of realizing a tractor beam for the exertion of negative force that offers an alternative to the use of negative-index materials,optical gain,or highly non-paraxial or multiple-light interference. | Cheng-Wei Qiu Weiqiang Ding MRCMahdy Dongliang Gao Tianhang Zhang Fook Chiong Cheong Aristide Dogariu Zheng Wang Chwee Teck Lim | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 7 | PRP及RGD联合修饰表面改性后仿生基质对ADSCs生物学行为的调控显示文摘目的 评估富血小板血浆(plateletrichplasma,PRP)及精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp.RGD)联合修饰表面改性后支架的细胞生物学特征,验证优化界面整合的方法。方法兔脂肪基质干细胞成骨诱导化,nB-TCP/Cs/PCL仿生基质Nd:YAG激光处理,表面改性及细胞接种:A组(PRP凝胶加RGD修饰表面改性基质加ADSCs)、B组(RGD修饰表面改性基质加ADSCs)、C组(表面改性基质加ADSCs)、D组(未表面改性基质加ADSCs);第1、4、8、12、16、20、24、28天,显微镜和电镜、共聚焦技术观察和检测细胞的存活率、增殖活力、Westenblot测定碱性磷酸酶及I型胶原蛋白表达活性,分析Runx2与OPG表达。结果A组细胞生长旺盛、细胞外基质丰富,存活率高于其它组(88.16±1.29,P〈0.05),增殖活力、碱性磷酸酶及I型胶原水平均高于其它组(0.92±0.13,87.27.4-3.08,93.27±3.91,P〈O.05),Runx2和OPG表达显著。结论PRP及RGD修饰联合支架表面改性能促进细胞增殖,为理想的骨整合方法。 | 郭洪刚 刘静 Yong Soon Chiong 姚芳莲 王芳 李晓眠 马信龙 | 2010 | 中华显微外科杂志2010，33，6： | 3 |
| 8 | 携载人重组骨形态形成蛋白2及脂肪基质细胞的仿生骨膜构建及强化兔桡骨的再生能力显示文摘目的:从仿生学角度出发,首次将脂肪基质细胞、人重组骨形态形成蛋白2、壳聚糖/胶原蛋白/β磷酸三钙膜材基质有机的结合,体外构建仿生骨膜,探讨仿生骨膜修复兔桡骨缺损的可行性,分析其生物相容性及骨再生特点。方法:实验于2005-05/2006-11分别在新加坡国立大学组织工程研究中心、天津医科大学完成。材料制备:成骨诱导化培养兔脂肪①基质细胞、制备释放人重组骨形态形成蛋白2的壳聚糖/胶原蛋白/β磷酸三钙膜材基质,联合生物凝胶+动态种植,三维方式构建仿生骨膜。②实验动物:72只新西兰兔随机分为3组:移植仿生骨膜组,移植诱导骨膜组,空白支架组。③实验方法:建立兔右侧桡骨10mm骨缺损模型,将制备的携载人重组骨形态形成蛋白2及脂肪基质细胞的仿生骨膜、携载人重组骨形态形成蛋白2的诱导骨膜、壳聚糖/胶原蛋白/β磷酸三钙膜材支架分别移植到各组骨缺损区域。④实验评估:术后第2,4,6,8,10,12周观察桡骨移植区域,了解新骨生长及重建情况。苏木精-伊红染色及Masson染色,观察骨组织修复情况。免疫组织化学观察骨形态形成蛋白的表达。双能X射线吸收法测量骨矿物含量、骨密度值。术后第12周,生物力学测试检查骨结构强度力学指标和刚度指标。结果:72只新西兰兔均进入结果分析。①大体观察显示:仿生骨膜组第6周有大量新生骨痂,第12周呈现骨性连接;诱导骨膜组骨质仅部分连接;空白支架组部分骨痂呈向心性生长。②组织学观察情况:仿生骨膜组第6周存在膜内成骨为主的大量新骨,第12周,恢复正常骨结构;诱导骨膜组存在软骨内成骨为主的新骨,第12周,缺损基本修复;空白支架组部分板层骨形成;各组均未见炎性及免疫排斥反应。③免疫组织化学观察:仿生骨膜组增生骨内膜、骨痂骨细胞、骨髓腔骨形态发生蛋白表达显著;诱导骨膜组软骨基质及部分骨膜出现骨形态发生蛋白表达;空白支架组仅软骨基质骨形态发生蛋白表达。④双能X射线吸收法检测:仿生骨膜组骨矿物含量、骨密度值均高于诱导骨膜组及空白支架组(P<0.05)。⑤生物力学测试:与诱导骨膜组、空白支架组相比,仿生骨膜组最大弯曲负荷及抗弯刚度显著提高(P<0.05)。结论:体外构建的仿生骨膜能有效的修复骨缺损,其生物相容性良好,通过协同诱导、引导、传导效应,增强骨再生能力,促进缺损修复。 | 郭洪刚 刘静 刘海峰 Yong Soon Chiong | 2007 | 中国组织工程研究与临床康复2007，11，48： | 2 |
| 9 | RGD修饰的仿生骨膜及纳米化诱导骨促进兔脊柱融合的实验研究显示文摘目的分析联用RGD修饰的仿生骨膜及纳米化诱导骨促进兔脊柱融合的可行性,探讨其应用潜力。方法成骨诱导化培养兔脂肪基质细胞、制备释放rhBMP-2的壳聚糖/胶原蛋白/B磷酸三钙膜材及生物衍生型复合基质,联合生物凝胶+动态种植,构建RGD修饰的仿生骨膜与纳米化诱导骨;建立兔腰5~6横突间融合模型,移植5组:A组RGD修饰的仿生骨膜及纳米化诱导骨;B组纳米化诱导骨;C组RGD修饰的仿生骨膜、D组空白支架(nCs-PCL-β-TCP),E组自体髂骨行组织学、免疫组织化学、双能X线吸收法、手动触检及生物力学检查。结果A组骨性融合能力最强,骨矿物含量(BMC)、骨密度值(BMD)、融合率及力学指标均高于其他组,差异具有统计学意义(P〈0.05);E、C组次之,B组融合相对延缓。D组未融合。结论RGD修饰的仿生骨膜及纳米化诱导骨能强化骨再生,通过协同诱导、引导、传导效应,促进脊柱融合。 | 郭洪刚 刘静 刘海峰 Yong Soon Chiong 马信龙 刘印忠 | 2009 | 中华小儿外科杂志2009，30，12： | 2 |
| 10 | Gallstone disease is associated with rectal cancer: a meta-analysis显示文摘 | Corinna Chiong Michael R. Cox Guy D. Eslick | 2012 | Scandinavian Journal of Gastroenterology2012，，5： | 2 |
| 11 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 12 | Effects of carvedilol on oxidative stress and ehronotropic response to exercise in patients with chronic heart failure显示文摘 | Castro P Vukasovic JL Chiong M | 2005 | Eur J Heart Fail2005，7，6： | 1 |
| 13 | Effects of angiotenist Ⅱ type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation显示文摘 | Kareti K R Chiong J R Hsu S S | 2005 | J Card Fail2005，11，： | 1 |
| 14 | Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis 显示文摘 | Parra V Eisner V Chiong M | 2008 | Cardiovasc Res2008，77，2： | 1 |
| 15 | Flow visualization and flow cytometry with holographic video microscopy显示文摘 | Cheong Fook Chiong Sun Bo Dreyfus R | 2009 | Opt Express2009，17，13： | 1 |
| 16 | Airway and craniofacial changes with mandibular advancement device in Chinese with obstructive sleep apnoea 显示文摘 | Pooh KH Chay SH Chiong KF | 2008 | Ann Acad Med Singapore2008，37，8： | 1 |
| 17 | Recent insights and therapeutic perspectives of angiotensin-(1-9)in the cardiovascular system显示文摘 | Ocaranza MP Michea L Chiong M | 2014 | Clin Sci(Lond)2014，127，9： | 1 |
| 18 | Effects of angiotenist Ⅱ type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation显示文摘 | Kareti K R Chiong J R Hsu S S | 2005 | J Card Fail2005，11，： | 1 |
| 19 | Autophagy as a therapeutic target in cardiovascular disease 显示文摘 | Nemchenko A Chiong M Turer A | 2011 | J Mol Cell Cardiol2011，51，4： | 1 |
| 20 | Investigating Pain in Heart Failure Patients: The Pain Assessment, Incidence, and Nature in Heart Failure (PAIN-HF) Study显示文摘 | Sarah J. Goodlin Sue Wingate Nancy M. Albert Susan J. Pressler Janet Houser Jennifer Kwon Jun Chiong C. Porter Storey Timothy Quill John R. Teerlink | 2012 | Journal of Cardiac Failure2012，，10： | 1 |
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