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| 1 | Endothelial progenitor cells in cardiovascular diseases显示文摘Endothelial dysfunction has been associated with the development of atherosclerosis and cardiovascular diseases. Adult endothelial progenitor cells(EPCs) are derived from hematopoietic stem cells and are capable of forming new blood vessels through a process of vas-culogenesis. There are studies which report correlations between circulating EPCs and cardiovascular risk fac-tors. There are also studies on how pharmacotherapies may influence levels of circulating EPCs. In this review, we discuss the potential role of endothelial progenitor cells as both diagnostic and prognostic biomarkers. In addition, we look at the interaction between cardio-vascular pharmacotherapies and endothelial progenitor cells. We also discuss how EPCs can be used directly and indirectly as a therapeutic agent. Finally, we evalu-ate the challenges facing EPC research and how these may be overcome. | Poay Sian Sabrina Lee Kian Keong Poh | 2014 | World Journal of Stem Cells2014，6，3： | 22 |
| 2 | 一种社交网络虚假信息传播控制方法显示文摘针对社交网络中日渐泛滥的虚假信息,提出了一种社交网络虚假信息传播控制方法Fidic,针对社交网络中虚假信息传播时途经的用户序列,该方法基于PageRank的思想并结合用户传播虚假信息时的指向关系来对用户进行评级,用户的评级越高表明其在虚假信息传播过程中起到的作用越大.该方法通过控制高评级用户的传播行为从而缩小虚假信息传播的覆盖面,最终达到遏制甚至消除虚假信息传播的目的.实验证明该方法既可以获得较高的精度,而且方便可行,具有较高实用价值. | 王永刚 蔡飞志 Eng Keong Lua 胡建斌 陈钟 | 2012 | 计算机研究与发展2012，49，S2： | 18 |
| 3 | Recurrent giant fibrovascular polyp of the esophagus显示文摘Giant fibrovascular polyps of the esophagus and hypopharynx are rare benign esophageal tumors. They arise most commonly in the upper esophagus and may, rarely, originate in the hypopharynx. They can vary significantly in size. Even though they are benign, they may be lethal due to either bleeding or, rarely, asphyxiation if a large polyp is regurgitated. Patients commonly present with dysphagia or hematemesis. The polyps may not be well visualized on endoscopy and imaging plays a vital role in aiding diagnosis as well as providing important information for preoperative planning, such as the location of the pedicle, the vascularity of the polyp and the tissue elements of the mass. They can also be recurrent in rare cases, especially if the resection margins of the base are involved. We review the recent literature and report a case of a 61-year-old man with a recurrent giant esophageal fibrovascular polyp with illustrative contrast barium swallow, CT and intra-operative images, who required several surgeries via a combination of endoscopic, trans-oral, trans-cervical, trans-thoracic and trans-abdominal approaches. | Ser Yee Lee Weng Hoong Chan Ranjiv Sivanandan Dennis Teck Hock Lim Wai Keong Wong | 2009 | World Journal of Gastroenterology2009，15，29： | 7 |
| 4 | Prevalence and Risk Factors of Atrial Fibrillation in Chinese Elderly: Results from the Chinese Longitudinal Healthy Longevity Survey显示文摘 | Choy-Lye Chei Prassanna Raman Chi Keong Chino Zhao-Xue Yin Xiao-Ming Shi Yi Zeng David B Matchar | 2015 | Chinese Medical Journal2015，，18： | 7 |
| 5 | 珍稀食药用真菌虎乳灵芝的研究概况显示文摘综述虎乳灵芝的分类地位、生物学性质、生物化学、营养价值及药理活性等方面的研究进展,并对其发展前景进行展望。 | 吴吉安 曾念开 CHOONG Yew keong 陈向东 | 2013 | 浙江农业科学2013，54，6： | 6 |
| 6 | Benign prostatic hyperplasia and male lower urinary symptoms:A guide for family physicians显示文摘Male patients with lower urinary tract symptoms(LUTS)and benign prostatic hyperplasia(BPH)are increasingly seen by family physicians worldwide due to ageing demographics.A systematic way to stratify patients who can be managed in the community and those who need to be referred to the urologist is thus very useful.Good history taking,physical examination,targeted blood or urine tests,and knowing the red flags for referral are the mainstay of stratifying these patients.Case selection is always key in clinical practice and in the setting of the family physician.The best patient to manage is one above 40 years of age,symptomatic with nocturia,slower stream and sensation of incomplete voiding,has a normal prostatespecific antigen level,no palpable bladder,and no haematuria or pyuria on the labstix.The roles of α blockers,5-α reductase inhibitors,and antibiotics in a primary care setting to manage this condition are also discussed. | Farhad Fakhrudin Vasanwala Michael Yuet Chen Wong Henry Sun Sien Ho Keong Tatt Foo | 2017 | Asian Journal of Urology2017，4，3： | 5 |
| 7 | CRYSTALLISATION KINETICS AND PHASE TRANSFORMATION BEHAVIOUR OF ELECTROLESS NICKEL-PHOSPHORUS DEPOSIT WITH 6-9wt% PHOSPHORUS CONTENT显示文摘Crystallisation kinetic and phase transformation behaviour of the electroless nickel-phosphorus deposit with 6-9wt% phosphorus content were studied. The deposit was heated in the differential scanning calorimetry (DSC) apparatus to 300℃-800℃ at 20℃/min, followed by the X-ray diffraction (XRD) analysis. The sequence of crystallisation process was: mixture of amorphous and microcrystalline nickel phases → intermediate metastable, f. c. c. nickel and stable N13P phases → f. c. c. nickel and stable Ni3P phases. Preferred orientation of nickel {200} plane was developed after the heating processes. Activation energy of crystallisation process was determined from the DSC analyses at 5-50℃/min. Crystallisation temperatures were found increased with increasing heating rate. | K.G. Keong, W. Sha and S. Malinov (School of Civil Engineering, The Queen’s University of Belfast, Belfast BT7 1NN, UK) | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 4 |
| 8 | 智慧促进健康,健康利增智慧——智慧健康引领医药卫生事业发展显示文摘智慧健康是将人类的智慧应用于人民的健康,将智慧含有的综合知识、技能、思想、方法、仪器、设备、材料等应用于健康事业,应用于药物开发、医疗保健、疾病诊治、养生康复、卫生防疫等诸多方面,并产生前所未有的高效,较为轻松、容易、方便、灵活地实现人类的健康目标。为了加速健康事业的快速发展,当代'智慧健康'研究领域引入了人工智能系统,集合了医学、药学、保健、信息、网络、计算机、远程通信、信号处理等多学科的知识、技能、技术、设备,构成了'智慧健康'的统一体与集约化。智慧地感知、智慧地运用、智慧地运作、智慧地管理、智慧地互动等,已经成为'智慧健康'的基石,具体表现在智能化采集健康信息,智能处理、应用健康知识与健康信息,形成健康的智能决策过程,应用网络和计算机等现代技术,建立起健康资源与健康需求联系的通道,形成云服务系统。在智慧健康条件下,人们可以利用这些互联网和远程通讯设备,多渠道获得更多的卫生保健知识,提高预防疾病和治疗疾病的水平。在智慧健康的时代,可望破解'看病难'、'看病贵'的社会难题。有了智慧健康,社会人群的个性化需求也较易实现,能更好地满足特殊需求,实现医疗服务的多样性和层次性。卫生服务与信息科技紧密结合,将共同为医药产业的发展指路领航。运用智慧健康的思路和方法研究中西医和中西药,寻觅二者之间物质基础的共同点,实现中西药理论会通,为中医药现代化、中西医结合、中西药会通等研究探寻出路,寻找突破方向。 | 王兴华 王光耀 盛良 汪宇 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui | 2015 | 智慧健康2015，1，1： | 4 |
| 9 | Can intravesical prostatic protrusion predict bladder outlet obstruction even in men with good flow?显示文摘Objective:Men with benign prostate hyperplasia(BPH)with good urinary flow may still have bladder outlet obstruction(BOO).Intravesical prostatic protrusion(IPP)has been shown to be able to predict BOO.We aim to investigate the use of IPP to predict BOO in men with good urinary flow.Methods:One hundred and fourteen consecutive men(>50 years old)presenting with lower urinary tract symptoms suggestive of BPH were recruited in 2001 and 2002.They were evaluated with serum prostate specific antigen(PSA),uroflowmetry and transabdominal ultrasound measurement of IPP and prostate volume(PV).Pressure-flow urodynamic studies were performed on all men and BOO was defined by BOO index>40.Men with Qmax12.0 mL/s were considered to have good flow.Results:Among the 114 men,61 patients had good urinary flow.Their median age,PV and Qmax were 66 years,32.9 mm3 and 14.5 mL/s respectively.14/61(23.0%)patients had BOO and their distribution of IPP were as follows:Grade 1 e 0/20(0%)obstructed,Grade 2 e 6/22(27.3%)and Grade 3 e 8/19(42.1%).Sensitivity of Grade 2/3 IPP for BOO was 100% while specificity of Grade 3 IPP was 76.6%.The area-under-curve(AUC)for IPP was greater than that for PV(0.757 vs.0.696).Conclusion:Even in men with good flow,high grades of IPP were more likely to have BOO and hence,may be a useful adjunct to predict BOO. | Alvin Lee Han Jie Lee Kok Bin Lim Hong Hong Huang Henry Ho Keong Tatt Foo | 2016 | Asian Journal of Urology2016，3，1： | 4 |
| 10 | Multiaxially-stretchable kirigami-patterned mesh design for graphene sensor devices显示文摘In wearable electronics,significant research has gone into imparting stretchability and flexibility to otherwise rigid electronic components while maintaining their electrical properties.Thus far,this has been achieved through various geometric modifications of the rigid conductive components themselves,such as with microcracked,buckled,or planar meander structures.Additionally,strategic placement of these resulting components within the overall devices,such as embedding them at the neutral plane,has been found to further enhance mechanical stability under deformation.However,these strategies are still limited in performance,failing to achieve fully strain-insensitive electrical performance under biaxial stretching,twisting,and mixed strain states.Here,we developed a new platform for wearable,motion artifact-free sensors using a graphene-based multiaxially stretchable kirigami-patterned mesh structure.The normalized resistance change of the electrodes and graphene embedded in the structure is smaller than 0.5%and 0.23%under 180°torsion and 100%biaxial strain,respectively.Moreover,the resistance change is limited to 5%under repeated stretching-releasing cycles from 0%to 100%biaxial strain.In addition,we investigated the deformation mechanisms of the structure with finite element analysis.Based on the simulation results,we derived a dimensionless geometric parameter that enables prediction of stretchability of the structure with high accuracy.Lastly,as a proof-of-concept,we demonstrated a biaxially-stretchable graphene-based sensor array capable of monitoring of temperature and glucose level with minimized motion-artifacts. | Hyo Chan Lee Ezekiel YHsieh Keong Yong SungWoo Nam | 2020 | Nano Research2020，13，5： | 3 |
| 11 | 运用电子鼻检测活血化瘀中药物质基础研究显示文摘目的探讨具有相同功效的中药材是否具有共同的物质基础,运用电子鼻能否对中药的药性进行初步量化。方法运用电子鼻检测常用具有活血化瘀功效的12种中药材,分析其PCA图和特征指纹图谱的相似性,并通过差异指数和判别指数对其作用作进一步说明。结果检测的12种具有活血化瘀功效的中药材具有相似的PCA图和特征指纹图谱。结论 12种活血化瘀的中药具有共同的物质基础。 | 王光耀 盛良 王兴华 汪宇 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui | 2015 | 智慧健康2015，1，1： | 3 |
| 12 | 蛋白质组学研究的原理、技术与应用显示文摘蛋白质组包括细胞或生物所表达的全部蛋白质,蛋白质组学是在大规模水平上研究蛋白质的特征,包括蛋白质的表达水平、翻译后的修饰、蛋白与蛋白之间的相互作用等。借以探析生命活动的生理基础及其内在规律,了解疾病发生、发展与细胞代谢过程,在蛋白质水平上获得整体而全面的认识,它是蛋白质(多肽)谱研究以及基因产物图谱研究的进一步延伸。蛋白质组学的核心技术是双向电泳、质谱及生物信息学,相关技术还涉及相对和绝对定量同位素标记、蛋白质芯片,多维色谱等。已被广泛应用于生命科学研究的诸多领域,尤其是癌症等危害人类较大的疾病防治,受到越来越多的关注。 | 王兴华 王光耀 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui 叶儒佳 王智航 | 2016 | 智慧健康2016，2，4： | 2 |
| 13 | Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment显示文摘Hepatocellular carcinoma(HCC)has become a challenging disease worldwide.There are still limitations in the diagnosis and treatment of HCC,and its high metastatic capacity and high recurrence rate are the main reasons for its poor prognosis.The ability of extracellular vesicles(EVs)to transfer functionally-active substances and their widespread presence in almost all body fluids suggest their unprecedented potential in the study of various cancers.The unique physicochemical properties of EVs determine their potential as antitumor vaccines and drug carriers.In the last decade,the study of EVs in HCC has evolved from a single hot topic to a system with considerable scale.This paper summarizes the role of EVs,especially exosomes,in the occurrence,metastasis and tumor immunity of HCC,reviews their applications in tumor diagnosis,prognosis and treatment,describes the pros and cons of these studies,and looks forward towards the future research directions of EVs in HCC. | Hang Wang Liang Yu Peng Huang Yongxu Zhou Wangyang Zheng Nanfeng Meng Risheng He Yi Xu Tey Sze Keong Yunfu Cui | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 14 | 中草药性味物质基础的化学探析显示文摘中草药的'四气五味'有物质基础,气味源于物质的化学成分,与其物质能量有关。化学反应中的电子、质子及带电基团得失吸推转移是能量变化的基础,酸碱理论和软硬酸碱原则以及前线轨道理论与中草药的气味学说相应,是其化学结构特性的反映,是众多化学成分在广义酸、碱性上的共同体现。电子鼻、电子舌能感受一类群化学物质,能区分中草药的'四气五味',做出准确鉴别。这将对中草药标准化、中草药质量控制、中西药会通、方剂配伍、中医现代化等一系列重大课题产生影响。 | 王兴华 王光耀 盛良 叶儒佳 Te Kian Keong TehSiew Hoon OoiCiat Hui | 2015 | 智慧健康2015，1，3： | 2 |
| 15 | Solving the benign prostatic hyperplasia puzzle显示文摘1.Introduction Benign prostatic hyperplasia(BPH)is a common urological condition,and yet there are many puzzles waiting to be solved.This perspective is to help explain some of these puzzles,based on our recent publications and previous clinical studies on BPH.2.Why small prostates obstruct and some big prostates do not obstruct? | Keong Tatt Foo | 2016 | Asian Journal of Urology2016，3，1： | 2 |
| 16 | Patients with small prostates and low-grade intravesical prostatic protrusion e A urodynamic evaluation显示文摘Abstract Objective:Despite high-grade intravesical prostatic protrusion(IPP)being closely related to bladder outlet obstruction(BOO),up to 21%of patients with low IPP remain obstructed.This study evaluates the characteristics and urodynamic findings of men with small prostates and low IPP.Methods:One hundred and fourteen men aged>50 years old with lower urinary tract symptoms(LUTS)were assessed with symptoms,uroflowmetry,serum prostate-specific antigen(PSA),transabdominal ultrasound measurement of prostate volume(PV),IPP and post-void residual urine(PVRU).All patients underwent pressure flow studies.Patients with PV<30 mL and IPP10 mm were examined for parameters correlating with BOO or impaired detrusor contractility.Results:Thirty-six patients had PV<30 mL and IPP<10 mm.Nine patients(25.0%)had urodynamic BOO,all with normal bladder contractility.Fourteen patients(38.9%)had poor detrusor contractility and all had no BOO.PV,PVRU and IPP were significantly associated with BOO,with IPP showing greatest positive correlation.Both Qmax and IPP were significantly associated with detrusor contractility.At 5-year follow-up,most patients responded to medical therapy.Only three out of nine patients(33.3%)with BOO eventually underwent surgery,and all had a high bladder neck seen on the resectoscope.Only one patient(7.1%)with poor detrusor contractility eventually required surgery after repeat pressure flow study revealed BOO.Conclusion:In men with small prostates and low IPP,the presence of BOO is associated with higher PV,PVRU and IPP,and most respond well to medical management.BOO can possibly be explained by elevation of the bladder neck by a small subcervical adenoma. | Han Jie Lee Alvin Lee Hong Hong Huang Palaniappan Sundaram Keong Tatt Foo | 2017 | Asian Journal of Urology2017，4，4： | 2 |
| 17 | A Review of Current Routing Protocols for Ad hoc Mobile Wireless Networks显示文摘 | Royer Elizabeth M Chai- keong Toh | 1999 | IEEE Personal Communication1999，6，2： | 2 |
| 18 | Pathophysiology of clinical benign prostatic hyperplasia显示文摘A disease can be defined as an abnormal anatomy(pathology)and/or function(physiology)that may cause harm to the body.In clinical benign prostatic hyperplasis(BPH),the abnormal anatomy is prostate adenoma/adenomata,resulting in a varying degree of benign prostatic obstruction(BPO)that may cause harm to the bladder or kidneys.Thus clinical BPH can be defined as such and be differentiated from other less common causes of male lower urinary tract symptoms.Diagnosis of the prostate adenoma/adenomata(PA)can be made by measuring the intravesical prostatic protrusion(IPP)and prostate volume(PV)with non-invasive transabdominal ultrasound(TAUS)in the clinic.The PA can then be graded(phenotyped)according to IPP and PV.Multiple studies have shown a good correlation between IPP/PV and BPO,and therefore progression of the disease.The severity of the disease clinical BPH can be classified into stages from stage Ⅰ to Ⅳ for further management.The classification is based on the effect of BPO on bladder functions,namely that of emptying,normal if postvoid residual urine(PVRU)<100 mL;and bladder storage,normal if maximum voided volume(MVV)>100 mL.The effect of BPO on quality of life(QoL)can be assessed by the QoL index,with a score≥3 considered bothersome.Patients with no significant obstruction and no bothersome symptoms would be stage Ⅰ;those with no significant obstruction but has bothersome symptoms(QoL≥3)would be stage Ⅱ;those with significant obstruction(PVRU>100 mL;or MVV<100 mL),irrespective of symptoms would be stage Ⅲ;those with complications of the disease clinical BPH such as retention of urine,bladder stones,recurrent bleeding or infections would be stage Ⅳ.After assessment,further management can then be individualised.A low grade and stage disease can generally be watched(active surveillance)while a high grade and stage disease would need more invasive management with an option for surgery.The final decision making would take into account the patient’s age,co-morbidity,social economic background and his preferences/values. Proper understanding of pathophysiology of clinical BPH would lead to better selection of patients for individualised and personalised care andmore cost effective management. | Keong Tatt Foo | 2017 | Asian Journal of Urology2017，4，3： | 2 |
| 19 | 地域视角下人工智能研究团队合作状态及其对比研究显示文摘[目的/意义]从地域视角出发,探讨人工智能研究团队的合作及其差异,以揭示跨地域或者地域内科研合作的状态与规律。[方法/过程]以Web of Science为数据来源,采集2009—2018年间人工智能学科领域所有科技论文数据,通过算法设计与人工核查进行数据清洗,从多维角度提取与划分研究团队。在此基础上,按地域划分3种类型合作模式,从对比角度综合分析各模式下团队中的地理位置分布、内部合作指标、合作主题内容3个方面,同时突出中国和美国人工智能研究团队的比较。[结果/结论]研究结果表明:中外人工智能研究核心团队均与科研大国保持密切联系;中国合作核心团体的国内合作依赖度较高,国际合作更有利于跨入核心团队行列;中国国内人工智能合作研究的主题主要表现在数据处理和应用层面,而核心技术层面和基础算法层面需与国外进行合作;中美在国际合作中,均占据重要地位且互为紧密合作对象。 | 王曰芬 曹嘉君 余厚强 Kwoh Chee Keong | 2020 | 科技情报研究2020，2，4： | 2 |
| 20 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
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