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| 1 | 肝细胞焦亡和炎性小体颗粒释放诱发肝星状细胞活化和肝纤维化显示文摘【据Journal of Hepatology 2020年8月报道】肝细胞焦亡和炎性小体颗粒释放诱发肝星状细胞活化和肝纤维化(作者Gaul S等)肝细胞死亡增加导致急性和慢性肝病的病理改变。肝细胞焦亡和细胞外炎性小体释放在肝病中的作用尚不清楚。来自美国圣地牙哥加利福尼亚大学儿科部的Gaul等使用原代小鼠和人肝细胞、肝细胞特异性L351P Nlrp3 KI CreA小鼠和Gsdmd KO小鼠研究肝细胞焦亡及其对肝脏炎症和损伤的影响。从突变型NLRP3-yfp HEK细胞中分离到细胞外NLRP3炎性体,并在LX2和原代人肝星状细胞中研究内化。进一步使用了154例经活检证实的NAFLD成人受试者的肝细胞(西澳大利亚奈德兰兹查尔斯·盖德纳爵士医院)。 | 李杰 牛俊奇 GAUL S LESZCZYNSKA A ALEGRE F | 2020 | 临床肝胆病杂志2020，36，10： | 26 |
| 2 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 3 | Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes显示文摘Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is unknown.This study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for NSTE-ACS.Methods LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged>80 years.Clinical variables and a complete geriatric evaluation were assessed during hospitalization.The association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding variables.We also analysed its association with 6-month bleeding and cognitive or functional decline.Results Among 527 patients included,thirty-seven(7%)patients presented delirium during the hospitalization.Delirium was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P<0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P<0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P<0.05)but similar cognitive or functional decline.Delirium was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P<0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality. | Miquel Vives-Borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators | 2019 | Journal of Geriatric Cardiology2019，16，2： | 3 |
| 4 | The pursuit of transplantation tolerance:new mechanistic insights显示文摘Donor-specific transplantation tolerance that enables weaning from immunosuppressive drugs but retains immune competence to non-graft antigens has been a lasting pursuit since the discovery of neonatal tolerance.More recently,efforts have been devoted not only to understanding how transplantation tolerance can be induced but also the mechanisms necessary to maintain it as well as how inflammatory exposure challenges its durability.This review focuses on recent advances regarding key peripheral mechanisms of T cell tolerance,with the underlying hypothesis that a combination of several of these mechanisms may afford a more robust and durable tolerance and that a better understanding of these individual pathways may permit longitudinal tracking of tolerance following clinical transplantation to serve as biomarkers.This review may enable a personalized assessment of the degree of tolerance in individual patients and the opportunity to strengthen the robustness of peripheral tolerance. | Pawan K.Gupta Christine M.McIntosh Anita S.Chong Maria-Luisa Alegre | 2019 | Cellular & Molecular Immunology2019，16，4： | 3 |
| 5 | Bile duct hamartomas-the von Meyenburg complex显示文摘ABSTRACT: Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma. We report a 42-year-old female patient with symptomatic cholecystitis, whose gross and ultrasonic appearance suggestive of multiple liver metastases. Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition. | Valdemir José Alegre Salles Alexandre Marotta Jorge Miguel Kather Netto Manlio Basílio Speranzini Marcos Roberto Martins | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 3 |
| 6 | Antidiabetic activities of Tecoma stans (L.) Juss. ex Kunth显示文摘 | L. Aguilar-Santamaría G. Ramírez P. Nicasio C. Alegría-Reyes A. Herrera-Arellano | 2009 | Journal of Ethnopharmacology2009，，2： | 2 |
| 7 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 8 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 9 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 10 | Novel purification method for recombinant 3AB1 nonstructural protein of foot-and-mouth disease virus for use in differentiation between infected and vaccinated animals 显示文摘 | NANNI M ALEGRE M COMPAIRED D | 2005 | J Vet Diagn Invest2005，17，3： | 1 |
| 11 | Differentiating between malignant and idiopathic pleural effusions:the value of diagnostic procedures显示文摘 | Aleman C Sanchez L Alegre J | 2007 | QJM2007，100，： | 1 |
| 12 | Vitreous amyloidosis without systemic or familial involvement显示文摘 | Salvador F Mateo C Alegre J | 1994 | Int Ophthalmol 1993-1994，17，6： | 1 |
| 13 | T-cell regulation by CD28 and CTLA-4显示文摘 | Alegre ML Frauwirth KA Thompson CB | 2001 | Nat Rev Immunol2001，1，3： | 1 |
| 14 | Thymidine kinase 1 up- regulation is an early event in breast tumor formation显示文摘 | MM Alegre RA Robison KL O' Neill | 2012 | J Oncol2012，20，57： | 1 |
| 15 | Effect of low temperature tempering prior cryogenic treatment on carburized steels显示文摘 | Preciado M Bravo P M Alegre J M | 2006 | Journal of Materials Processing Technology2006，176，1： | 1 |
| 16 | Enhanced oxidation of flava- neols and proanthocyanidin accumulation in water - stressed tea Plants 显示文摘 | Hemandez I Alegre L Munne - Bosch S | 2006 | Phytochemistry2006，67，： | 1 |
| 17 | The subtha- lamic nucleus is involved in successful inhibition in the stopsignal task: a local field potential study in Parkinson's disease显示文摘 | Alegre M Eopez-Azcarate J Obeso I | 2013 | Exp Neurol2013，239，： | 1 |
| 18 | Shaping the Firm' S External Search Strategy 显示文摘 | Granero A C Jurado J V Alegre J | 2014 | Innovation Management Policy and Prac- tices2014，16，3： | 1 |
| 19 | Diurnal of variations of photosynthesis and dew absorption by leaves in two evergreen shrubs growing in Mediterranean field conditions显示文摘 | Munn~-Bosch S Nogu6s S Alegre L | 1999 | New Phy- tologist1999，144，： | 1 |
| 20 | Regulatory role of tryptophan degradation pathway in HLA-G expression by human mono- cyte-derived dendritic cells 显示文摘 | Lopez A S Alegre E LeMaouh J | 2006 | Mol Immunol2006，43，14： | 1 |
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