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| 1 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 3 | Keloids and hypertrophic scars: review and treatment strategies 显示文摘 | Urioste S S Arndt K A Dover J S | 1999 | Semin Cutan Med Surg1999，18，2： | 1 |
| 4 | Keloids and hypertrophic scars:review and treatment strategies显示文摘 | Urioste SS Amdt KA Dover JS | 1999 | Semin Cutan Med Surg1999，18，1： | 1 |
| 5 | Allelic losses and genetic instabilities of PTEN and p73 in non-Hodgkin lymphomas显示文摘 | Urioste M Santos J | 2000 | Leukemia2000，14，7： | 1 |
| 6 | Keloids and hypertrophytic scars,review and treatment strategies显示文摘 | Urioste SS Amdt KA Dover JS | 1999 | Semin Gutan Med Sury1999，18，： | 1 |
| 7 | Long - term safety and efficacy of the selective aldosterone blocker eplerenone in pa- tients with essential hypertension 显示文摘 | Burgess ED Lacourciere Y Ruilope - Urioste LM | 2003 | Clin Ther2003，25，9： | 1 |
| 8 | NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes 显示文摘 | Hansen L Jensen JN Urioste S | 2000 | Diabetes2000，49，： | 1 |
| 9 | Keloids and hypertrophic scars:review and treatment strategies显示文摘 | Urioste SS Arndt KA Dover JS | 1999 | Semin Cutan Med Surg1999，18，2： | 1 |
| 10 | Identification of breeding objectives using a bio-economic model for a beef cattle production system in Uruguay 显示文摘 | Pravia M I Ravagnolo O Urioste J I et ol | 2014 | Livest Sci2014，160，： | 1 |
| 11 | Cultivation effects on phosphate forms sorption in loesssoils of Argentina显示文摘 | BUSCHZAZZO D E HEVIA G G URIOSTE A M | 2000 | Soil Sci2000，165，5： | 1 |
| 12 | Cultivation effects on phosphate forms and sorption inloess-soils of Argentina显示文摘 | Buschiazzo DE Hevia GG Urioste AM Hepper EN | 2000 | Soil Science2000，165，42： | 1 |
| 13 | Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array显示文摘 | Urioste M Melcho L | 2005 | Genes Chromosome Canc2005，42，3： | 1 |
| 14 | High-frequency network oscillation in the hippocampus显示文摘 | BUZSAKI G HORVATH Z URIOSTE R | 1992 | Science1992，256，： | 1 |
| 15 | Keloids and hypertrophytic scars,review and treatm ent strategies显示文摘 | Urioste SS Am dt KA Dover JS | 1999 | Sem in Gutan Med Sury1999，10，8： | 1 |
| 16 | Complex cytogenetic abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma 显示文摘 | Urioste M Martinez- Ramirez A Cigudosa JC et al | 2002 | Cancer Genet Cytogenet2002，138，2： | 1 |
| 17 | Keloids and hypertrophic scars:review and treatment strategies显示文摘 | Urioste SS Amdt KA Dover JS | 1999 | Semin Cutan Med Surg1999，18，： | 1 |
| 18 | NeuroD/BETA2 gene variability and diabetes : no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes 显示文摘 | Hansen L Jensen JN Urioste S | 2000 | Diabetes2000，49，5： | 1 |
| 19 | Long- term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension显示文摘 | Lacourciere Y Ruilope - Urioste LM | 2003 | Clin Ther2003，25，9： | 1 |
| 20 | Genetic relationships among mastitis and alternative somatic cell count in the first 3lactations of Swedish Holsteins显示文摘 | URIOSTE J I FRANZEN J WINDIG J J | 2012 | Journal of Dairy Science2012，95，6： | 1 |
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