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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | A review on therapeutic potential of Nigella sativa:A miracle herb显示文摘Nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil have a long history of folklore usage in various systems of medicines and food.The seeds of N.saliva have been widely used in the treatment of different diseases and ailments.In Islamic literature,it is considered as one of the greatest forms of healing medicine.It has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin disorders.Extensive studies on N.sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,etc.Due to its miraculous power of healing,N.sativa has got the place among the top ranked evidence based herbal medicines.This is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant. | Aftab Ahmad Asif Husain Mohd Mujeeb Shah Alam Khan Abul Kalam Najmi Nasir Ali Siddique Zoheir A.Damanhouri Firoz Anwar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 16 |
| 3 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 4 | Conversion of Malaysian low-rank coal to mesoporous activated carbon:Structure characterization and adsorption properties显示文摘Malaysian Selantik low-rank coal(SC)was used as a precursor to prepare a form of mesoporous activated carbon(SC-AC)with greater surface area(SA)via a microwave induced KOH-activation method.The characteristics of the SC and SC-AC were evaluated by the iodine number,ash content,bulk density,and moisture content The structure and surface characterization was carried out using pore structure analysis(BET),scanning electron microscopy with energy dispersive X-ray spectroscopy(SEM-EDX),X-ray diffraction(XRD),Fourier Transform Infrared(FTIR),elemental analysis(CHNS),thermogravimetric analysis(TGA),and determination of the point of zero charge(pH(PZC)).These results signify a mesoporous structure of SC-AC with an increase of ca.1160 times(BET SA=1094.3 m^2·g^-1)as compared with raw SC without activation(BET SA=1.23 m^2·g^-1).The adsorptive properties of the SC-AC with methylene blue(MB)was carried out at variable adsorbent dose(0.2-1.6 g·L^-1),solution pH(2-12),initial MB concentrations(25-400 mg·L^-1),and contact time(0-290 min)using batch mode operation.The kinetic profiles follow pseudo-second order kinetics and the equilibrium uptake of MB conforms to the Langmuir model with a maximum monolayer adsorption capacity of 491.7 mg g^-1 at 303 K.Thermodynamic functions revealed a spontaneous endothermic adsorption process.The mechanism of adsorption included mainly electrostatic attractions,hydrogen bonding interaction,andπ-πstacking interaction.This work shows that Malaysian Selantik low-rank coal is a promising precursor for the production of low-cost and efficient mesoporous activated carbon with substantive surface area. | Ali H.Jawad Khudzir Ismail Mohd Azlan Mohd Ishak Lee D. Wilson | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 7 |
| 5 | Effect of Primary and Eutectic Mg_2Si Crystal Modifications on the Mechanical Properties and Sliding Wear Behaviour of an Al–20Mg_2Si–2Cu–xBi Composite显示文摘This work investigated the microstructure evolution, tensile, impact, hardness, and sliding wear properties of an Al–20Mg_2Si–2Cu in situ composite treated with different Bi contents. The desired modification of primary Mg_2 Si particles was achieved with the addition of 0.4 wt% Bi. Increasing Bi beyond 0.4 wt%resulted in a loss of modification, possibly due to the formation of Al_8 MgB iS i4 compound before the precipitation of the primary Mg_2 Si. Additionally, the structure of the pseudo-eutectic Mg_2 Si was transformed from plate to fibrous, which was consistent with decrease of growth temperature extracted from the cooling curve thermal analysis. Addition of Bi had an effect on the morphology of Al_5 Fe Si(β), Al_2Cu(θ) and Al_5Cu_2Mg_8Si_6(Q) intermetallic compounds. The tensile strength, elongation percentage, impact toughness, and hardness increased by 6%, 13%, 75%, and 23%, respectively, due to modification of both the primary and eutectic Mg_2 Si crystals. The tensile and impact fracture surfaces showed fewer decohered particles in the Bi-treated composite. The enhancement in wear resistance of the Bi-treated composite could be attributed to solid lubricant function of insoluble soft Bi phase and modification effects on Mg_2 Si particles. | Saeed Farahany Hamidreza Ghandvar Nur Azmah Nordin Ali Ourdjini Mohd Hasbullah Idris | 2016 | Journal of Materials Science & Technology2016，32，11： | 7 |
| 6 | Review of sustainability, pretreatment, and engineering considerations of asphalt modifiers from the industrial solid wastes显示文摘The escalating mass of solid waste at an overwhelming sum requires a global attention to strive for efficient waste management and to outsource the ecological treatments. The asphalt pavement industry that consumes a vast scale of natural resources while contributing to thermal and greenhouse emissions is viewed as a high potential alternative for the application of solid waste as asphalt modifier and substantial waste reduction. In efforts to urge for cleaner and greener asphalt production, a growing trend towards usage of solid waste as a renewable material is paving a sustainable future for the asphalt pavement industry. The economic options of incorporating solid waste into the asphaltic mixture coupled with proven effective performances are a green and cost-effective alternative to mitigate various pavement distresses. Various options either as coarse or fine aggregates and as fillers in powder, ash, or fibre form are to stimulate further research interest to incorporate a diversified range of solid waste into the asphalt binder and asphalt mixture. Prior to incorporating solid waste into the asphaltic mixture through the selected options, prerequisite tests in addressing engineering limitations due to the unknown properties of solid waste are reviewed. The concerns on environmental impact are given heavy metals leaching possibilities into water sources are addressed by Toxicity Characterization Leaching Procedure test, to leverage further the systematic reuse of solid waste in steering towards the cleaner production of the asphalt mixture. The microcosmic traits of solid waste namely surface morphology, mineralogical composition and chemical composition are summarized based on the usage of Scanning Electron Microscope, X-Ray Diffraction, and X-Ray Fluorescence, respectively. This systematic review is an enactment and stimulus for researchers to have a general overview before incorporating solid waste into asphalt mixture. | Mohd Rosli Mohd Hasan J-Wei Chew Ali Jamshidi Xu Yang Meor Othman Hamzah | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，3： | 7 |
| 7 | New coating formulation for the slow release of urea using a mixture of gypsum and dolomitic limestone显示文摘 | Farahnaz Eghbali Babadi Robiah Yunus Suraya Abdul Rashid Mohamad Amran Mohd Salleh Salmiaton Ali | 2015 | Particuology2015，13，6： | 6 |
| 8 | 涂层厚度对消失模铸Al-Si-Cu合金铸件的影响(英文)显示文摘对Al-Si-Cu合金进行消失模铸造,研究涂层厚度对Al-Si-Cu合金铸件缺陷、孔隙率和共晶硅间距的影响。结果表明,提高涂层浆料黏度和延长浸渍时间对铸件的完整性和显微组织有影响。薄的涂层有利于模腔充填性能的改善、显微组织的细化和低孔隙度高质量铸件的获得。 | Majid KARIMIAN Ali OURDJINI Mohd HASBULLAH IDRIS Hassan JAFARI | 2012 | Transactions of Nonferrous Metals Society of China2012，22，9： | 5 |
| 9 | 影响增殖性糖尿病视网膜病变玻璃体切除术后视力改善的因素(英文)显示文摘目的:分析影响增殖性糖尿病视网膜病变(PDR)玻璃体切除术后视力改善的因素。方法:回顾性分析。收集2014-01/2014-12在马来西亚吉打州,亚罗士打Sultanah Bahiyah医院收治的PDR行玻璃体切除术病例资料,包括1y内患者统计,基线视力(VA)和LogMAR术后最佳矫正视力。使用IBM SPSS Statistics Version 22.0进行数据分析。结果:共103例患者。平均年龄51.2y。在多变量分析中,每个0 logMAR基线VA的1 logMAR术前正偏差与0.859logMAR的术后改善相关(P<0.001)。同样,术前附着的黄斑与玻璃体切除术后的logMAR视力改善相关(b=0.374,P=0.003)。无虹膜新血管和无术后并发症与玻璃体切除术后改善的logMAR视力相关,分别为1.126(P=0.001)和0.377(P=0.005)。无长效眼内填充与玻璃体切除术后logMAR视力改善相关,为0.302(P=0.010)。结论:玻璃体切除术后与视力改善的相关因素是:术前视力较差,黄斑附着,无虹膜新生血管,无术后并发症和未使用长效眼内填充物。了解视力改善的因素将有助于玻璃体视网膜手术的决策。 | Evelyn Tai Li Min Goh Yihu Wan-Hazabbah Wan Hitam Haslina Mohd Ali | 2017 | 国际眼科杂志2017，17，8： | 4 |
| 10 | Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study显示文摘 | Yahya Shehabi Lucy Chan Suhaini Kadiman Anita Alias Wan Nasrudin Ismail Mohd Ali T. Ismail Tan Tien Meng Khoo Saedah Binti Ali Mat Ariffin Saman Ahmad Shaltut Cheng Cheng Tan Cow Yen Yong Michael Bailey | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 11 | Advances in reduction of NO_x and N_2O emission formation in an oxy-fired fluidized bed boiler显示文摘Fossil fuel combustion is one of the major means to meet the mounting global energy demand. However, the increasing NO_x and N_2 O emissions arising from fossil fuel combustion process have hazardous effects. Thus, mitigating these gases is vital to attain a sustainable environment. Interestingly, oxy-fuel combustion in fluidized bed for carbon capture and minimized NO_x emissions is strongly sustainable compare to the other approaches. It was assessed that NO_x formation and fuel-N conversion have significant limitation under oxy-fluidized bed compared to air mode and the mechanism of NO_x formation is still deficient and requires further development. In addition, this review paper discussed the potential of primary measure as low emission process with others supplementary techniques for feasible NO_x reduction. The influences of combustion mode, operating parameters, and reduction techniques such as flue gas recirculation, oxygen staging, biomass co-firing, catalyst, influence of fluidized bed design and structure, decoupling combustion and their merges are respectively evaluated. Findings show that significant minimization of NO_x emission can be achieved through combination of primary and secondary reduction techniques. | Khalid El Sheikh Mohammad Jakir Hossain Khan Mahar Diana Hamid Siddhartha Shrestha Brahim Si Ali G.A.Ryabov Lya A.Dolgushin Mohd Azlan Hussain Tatiana V.Bukharkina Elena A.Gorelova | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 12 | Artificial neural network simulation for prediction of suspended sediment concentration in the River Ramganga,Ganges Basin,India显示文摘The relation between the water discharge (Q) and suspended sediment concentration (SSC) of the River Ramganga at Bareilly, Uttar Pradesh, in the Himalayas, has been modeled using Artificial Neural Networks (ANNs). The current study validates the practical capability and usefulness of this tool for simulating complex nonlinear, real world, river system processes in the Himalayan scenario. The modeling approach is based on the time series data collected from January to December (2008-2010) for Q and SSC. Three ANNs (T1-T3) with different network configurations have been developed and trained using the Levenberg Marquardt Back Propagation Algorithm in the Matlab routines. Networks were optimized using the enumeration technique, and, finally, the best network is used to predict the SSC values for the year 2011. The values thus obtained through the ANN model are compared with the observed values of SSC. The coefficient of determination (R2), for the optimal network was found to be 0.99. The study not only provides insight into ANN modeling in the Himalayan river scenario, but it also focuses on the importance of understanding a river basin and the factors that affect the SSC, before attempting to model it. Despite the temporal variations in the study area, it is possible to model and successfully predict the SSC values with very simplistic ANN models. | Mohd Yawar Ali Khan Fuqiang Tian Faisal Hasan Govind Joseph Chakrapani | 2019 | International Journal of Sediment Research2019，34，2： | 2 |
| 13 | Influence of Gating System,Sand Grain Size,and Mould Coating on Microstructure and Mechanical Properties of Thin-Wall Ductile Iron显示文摘Two gating systems namely stepped and tapered runners were used to cast strip samples with different thicknesses by CO2/silicate process using sand grain sizes of AFS 151 and 171.To assess the effect of mould coating on the properties of thin-wall ductile iron,half of the moulds were coated whilst the rest were not coated.Molten metal with the carbon equivalent of 4.29% was prepared and poured at 1450 ℃.Microstructure of the specimens was analyzed by optical and scanning electron microscopes.Count,area fraction,roundness and diameter of the graphite nodules of the samples were measured by image analyzer.Brinell hardness and tensile tests of all the samples were also conducted.The results show that by using stepped runner gating system with uncoated and coarse sand mould,roundness and count of the graphite nodules decrease whereas diameter and area fraction increase.Although fine sand and coated mould cause longer distance of molten metal travel,hardness and strength of the samples decrease. | Hassan Jafari Mohd Hasbullah Idris Ali Ourdjini Majid Karimian Gholamhassan Payganeh | 2010 | Journal of Iron and Steel Research(International)2010，17，12： | 2 |
| 14 | Prevalence of H elicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in K ashmir, I ndia显示文摘 | Jaswinder Singh Sodhi Gul Javid Showkat Ali Zargar Syed Tufail Altaf Shah Bashir Ahmad Khan Ghulam Nabi Yattoo Ghulam Mohamad Gulzar Mushtaq Ahmad Khan Mohd Iqbal Lone Riyaz u Saif Shaheena Parveen Abid Shoukat | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 15 | The effects of carbonization temperature on pore development in palm-shell-based activated carbon显示文摘 | Wan Mohd Ashri Wan Daud Wan Shabuddin Wan Ali Mohd Zaki Sulaiman | 2000 | Carbon2000，38，： | 1 |
| 16 | Investigation of the over current characteristics of HTS tapes considering the application for HTS power devices 显示文摘 | Kim Jae - Ho Park Minwon Ali Mohd Hasan | 2008 | IEEE Transactions on Applied Superconductivity2008，18，2： | 1 |
| 17 | A Review of Pneumatic Actuators (modeling and Control)显示文摘 | Hazem I Ali Samsul Bahari B Mohd Noor S M Bashi M H Marhaban | 2009 | Australian Journal of Basic and Applied Sciences2009，3，2： | 1 |
| 18 | A comparative study on wall degrading enzymes, pectin modifications and softening during ripening of selected tropical fruits 显示文摘 | Low temperature storage and modified atmosphere packa- changes wall modification and chilling injury symptoms Zainon Mohd Ali Lieng-Hong Chin Hamid Lazan | 2004 | Plant Science2004，167，2： | 1 |
| 19 | New Aliphatic Alcohol and Ester Constituents from Rice Hulls of Oryza sativa显示文摘n-octacos-9-enyl propionate ( 1 )的六新脂肪族的白酒和酉旨混合物,4-( 3-formylheptyl )出租机动三轮车--己基的4-( cyclohexylcarbonyloxymethyl )cyclohexyl羧化物( 2 ), n-hentriacont-25-en-5-ol ( 3 ),n-hexetriacont- 9,26-dien-8,11,23-triol ( 4 ), n-tetracontan-15-ol ( 5 )和 n-tritetracontan-5-ol ( 6 )从 Oryza sativa 的壳被孤立。结构根据分光镜的分析被建立。 | CHUNG, ILL-Min ALI, Mohd CHUN, Se-Chul JIN, Cheng-Wu CHO, Dong-Ha HONG, Seung-Beom AHMAD, Ateeque | 2007 | Chinese Journal of Chemistry2007，25，6： | 1 |
| 20 | A compar ative study on wall degrading enzymes, pectin modifications and softening during ripening of selected tropical fruits 显示文摘 | Zainon Mohd Ali Lieng-Hong Chin Hamid Lazan | 2004 | Plant Science2004，167，： | 1 |
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