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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Cost-sensitive learning based on Bregman divergences 显示文摘 | RAUL S R ROCIO A R ALICIA G C | 2009 | Machine Learning Journal2009，76，： | 1 |
| 4 | 16S rRNA gene sequence analysis of Photobacterium damselae and nested PCR method for rapid detection of the causative agent of fish pasteruellosis显示文摘 | CARLOS R O MATTHEW D C ALICIA E T | 1999 | Appl Environ Microbiol1999，65，7： | 1 |
| 5 | Effect of com- bined treatment with hot air and UV-C on senescence and quality parameters of minimally processed broccoli( Bras- sica oleracea L var Italica) 显示文摘 | Maria L L Pedro M C Alicia R C | 2008 | Postharvest Biology and Technology2008，48，1： | 1 |
| 6 | Effect of heat treatment on strawberry fruit damage and oxidative metabolism during storage显示文摘 | Ariel R V Gustavo A M Alicia R C | 2006 | Postharvest Biolog'' and Teclmolo:v2006，40，： | 1 |
| 7 | Texture changes in fresh - cut celeryduring refrigerated storage显示文摘 | Sonia Z V Alicia R C | 2003 | Science of Food and Agriculture2003，83，13： | 1 |
| 8 | Effect of heat treatment on strawberry fruit damage and oxidative metabolism during storage显示文摘 | ARIEL R V GUSTAVO A M ALICIA R C | 2006 | Postharvest Biology and Technology2006，40，6： | 1 |
| 9 | Effect of heat treatment on Strawberry fruit damage and oxidative metabolism during storage 显示文摘 | ARIEL R V GUSTAVO A M ALICIA R C | 2006 | Postharvest Biology and Technology2006，40，： | 1 |
| 10 | Effect of chilling on ethylene production in eggplant fruit 显示文摘 | Analia Concellon Maria C Anon Alicia R Chaves | 2005 | Food Chemistry2005，92，1： | 1 |
| 11 | Uterine Fibroids:Uterine Artery Embolization versus Abdominal Hysterectomy for Treatment-A Prospective,Randomized,and Controlled Clinical Trial显示文摘 | Isabel P Paloma C Alicia R | 2003 | Radiology2003，226，： | 1 |
| 12 | Effect of heat treatment on strawberry fruit damage and oxidative metabolism during storage 显示文摘 | Ariel R V Gustavo A M Alicia R C Civello P M | 2006 | Postharvest Biology and Technology2006，40，2： | 1 |
| 13 | Texture changes in fresh-cut celery during refrigerated storage 显示文摘 | Sonia Z V Alicia R C | 2003 | Science of Food and Agriculture2003，83，13： | 1 |
| 14 | Parvovirus-like particles as vaccine vectors 显示文摘 | Ignacio C J Paloma R Alicia H | 1999 | Methods1999，19，： | 1 |
| 15 | The Rela- tionship of Organizational Politics and Support to Work Behaviors, Attitudes, and Stress 显示文摘 | Cropanzano R Howes John C Grandey Alicia A | 1997 | Journal of Organizational Behavior1997，18，2： | 1 |
| 16 | Influence of self-produced CO2 on postharvest life of heat treated strawberries显示文摘 | Ariel R V Gustavo A M Alicia R C | 2003 | Postharvest Biology and Technology2003，27，： | 1 |
| 17 | Antioxidant responses in minimally processed celery during refrigerated storage 显示文摘 | Sonia Z V Alicia R C | 2006 | Food Chemistry2006，94，1： | 1 |
| 18 | Comparison of different genetic markers for molecular epidemiology of bovine tuberculosis 显示文摘 | Maria I R Alicia A Juan C F | 1996 | Veterinary Microbiology1996，50，： | 1 |
| 19 | Ethnic Differences in C-Reactive Protein Concentrations显示文摘 | Lloyd-Jones Donald M Colvin Alicia Matthews Karen A Johnston Janet Sowers MaryFran R Sternfeld Barbara Pasternak Richard C Chae Claudia U | 2008 | Clinical Chemistry2008，，6： | 1 |
| 20 | Antioxidant responses in minimally processed celery during refrigerated storage显示文摘 | SONA A V ALICIA R C | 2006 | Food Chemistry2006，，94： | 1 |
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