|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Adsorption of thiacyanine dyes on silver hilide nanoparticles:study of the adsorption site显示文摘 | Jeunieau L Alin V Nagy B | 2000 | Langmuir2000，16，： | 1 |
| 3 | Monte Carlo localization for mobile wireless sensor networks显示文摘 | Aline B Koen L | 2006 | Lecture Notes in Computer Science2006，4325，11： | 1 |
| 4 | Purification of GSK 3 by affinity chromatography on immobilized axin显示文摘 | Aline P Blandine B Marie G | 2000 | Protein Exp and Purifiea2000，20，3： | 1 |
| 5 | The role of rhizobacteria in rice plants: Growth and mitigation of toxicity显示文摘Allelopathic compounds reduce the growth and productivity of upland rice plants, especially in consecutive plantations. The rhizobacteria Pseudomonas fluorescens BRM-32111 and Burkholderia pyrrocinia BRM-32113 have been recorded as growth promoters in rice. This study was developed to understand the effect of the application of rhizobacteria on upland rice plants in consecutive plantations. Experiments were conducted in a completely randomized design with four replications of four treatments: rice seed inoculated with P. fluorescens BRM-32111, rice seed inoculated with B. pyrrocinia BRM-32113(both sown on soil with rice residue), non-inoculated plants sown on soil with rice residue(control with residue(WR)), and non-inoculated plants on soil with no residue(NR). Roots and seedling growth were adversely affected by allelopathic compounds in control WR plants. Plants inoculated with rhizobacteria P. fluorescens BRM-32111 or B. pyrrocinia BRM-32113 induced an increase of 88% in biomass, 3% in the leaf area, 40% in length, 67% in root biomass, 21% in chlorophyll a, 53% in chlorophyll(a+b), 50% in rate of carbon assimilation(A), 227% in A/rubisco carboxylation efficiency(C_i) and 63% in water use efficiency(WUE) compared to control WR plants. These results indicate that rhizobacteria P. fluorescens BRM-32111 and B. pyrrocinia BRM-32113 increase the tolerance of rice plants to stress from allelochemicals. There are possible practical agricultural applications of these results for mitigating the effects of environmental allelochemistry on upland rice. | Marcela C F Rêgo Aline F Cardoso Thayná da C Ferreira Marta C C de Filippi Telma F V Batista Rafael G Viana Gisele B da Silva | 2018 | Journal of Integrative Agriculture2018，17，12： | 1 |
| 6 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling 显示文摘 | ALINE R B EMILENE M B CI~LINE L | 2011 | Spectrochimica Acta Part B2011，66，7： | 1 |
| 7 | Prognostic impact of isoeitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group 显示文摘 | Nicolas B Olivier N Aline R | 2010 | J Clin Oncol2010，28，23： | 1 |
| 8 | Occupational Exposure of Farm Workers to Pesticides:Biochemical Parameters and Evaluation of Genotoxicity显示文摘 | ALINE P R ALVES M JANE M B | | 0，，： | 1 |
| 9 | High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate显示文摘We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic electrons.SHHG spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity c.For all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/10.This universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions. | Stefan Haessler Marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy Louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens | 2022 | Ultrafast Science2022，，3： | 1 |
| 10 | 查看详情显示文摘 | Aline R B Emilene M B Celine L Maria G R V Sergio L C F Bernhard W | | 0，，： | 1 |
| 11 | Coastal erosion in eastern black sea region, Turkey显示文摘 | Omer Yuksek Hizir Onsoy Alin R B | 1995 | Coastal Engineering1995，，26： | 1 |
| 12 | Age - related changes in oxidized proteins 显示文摘 | Oliver C N Alin B W Moerman E J | 1987 | The Journal of Biological Chemistry1987，262，12： | 1 |
| 13 | Monte-Carlo Localization for mobile wireless sensor networks 显示文摘 | ALINE B KOEN L | 2006 | Ad Hoc Networks2006，6，5： | 1 |
| 14 | Maternal Personal Exposure to Airborne Benzene and Intrauterine Growth显示文摘 | Slama Rémy Thiebaugeorges Olivier Goua Valérie Aussel Lucette Sacco Paolo Bohet Aline Forhan Anne Ducot Béatrice Annesi-Maesano Isabella Heinrich Joachim Magnin Guillaume Schweitzer Michel Kaminski Monique Charles Marie-Aline | 2009 | Environmental Health Perspectives2009，，8： | 1 |
| 15 | Spatial patterns of photosynthesis in thin-and thick-leaved epiphytic orchids:unravelling C3-CAM plasticity in an organ-compartmented way显示文摘 | IVhria A R Alejandra M Aline B C | 2013 | Annals of Botany2013，112，： | 1 |
| 16 | Localized hyperhldrosis treated with aluminum chloride in a salicylic acid in a salicylic acid gel ase显示文摘 | Antranik B Alin D Chantal B | 1998 | Int J Dermatology1998，37，9： | 1 |
| 17 | MonteCarlo localization formobile wireless sensor networks显示文摘 | Aline B Koen L | 2008 | Ad Hoe Networks2008，6，5： | 1 |
| 18 | Purification of GSK-3 by affinity chromatography on immobilized Axin 显示文摘 | Aline P Blandine B Marie G | 2000 | Protein Exp and Purifica2000，20，3： | 1 |
| 19 | Method develop- ment for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling 显示文摘 | Aline R B Emilene M B Celine L | 2011 | Spectrochimica Acta Part B2011，66，7： | 1 |
| 20 | Respiratory carbon fluxes in leaves 显示文摘 | Guillaume T Edouard B Aline M | 2012 | Current Opinion in Plant Biology2012，15，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员