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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys显示文摘 | Christopher L Coe Marian Kramer Boldizsár Czéh Elizabeth Gould Alison J Reeves Clemens Kirschbaum Eberhard Fuchs | 2003 | Biological Psychiatry2003，，10： | 1 |
| 3 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 4 | Com-parative toxicity and carcinogenicity of two chlorinated paraffins in F344N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | | 0，，03： | 1 |
| 5 | Telomere shortening in atherosclerosis显示文摘 | Nilesh J Samani Rachel Boultby Robert Butler John R Thompson Alison H Goodall | 2001 | The Lancet2001，，9280： | 1 |
| 6 | Rice yield and nitrogen utilization efficiency under alternative straw management practices显示文摘 | Alison J E Jeffrey A B William R H | 2000 | Agron J2000，92，6： | 1 |
| 7 | Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | 1987 | Fundamental and Applied Toxicology:Official Journal of the Society of Toxicology1987，9，3： | 1 |
| 8 | Microfluidics for Medical Diagnostics and Biosensors 显示文摘 | Catherine R Lee H Alison H | 2011 | Chemical Engineering Science2011，66，7： | 1 |
| 9 | Strategic Distribution of Protective Proteins within Bran Layers of Wheat Protects the Nutrient-Rich Endosperm1[W][OA]显示文摘 | Jerkovic Ante Kriegel Alison M Bradner John R Atwell Brian J Roberts Thomas H Willows Robert D | 2010 | Plant Physiology2010，，3： | 1 |
| 10 | Nucleation control in solution mediated polymorphic phase transformations:the case of 2,6-dihydroxybenzoic acid显示文摘 | Davey R J Blagden N Righini S Alison H Ferrari E S | | 0，，： | 1 |
| 11 | Microfluidics for medical diagnostics and biosensors显示文摘 | Catherine R Hyewon L Alison H | | 0，，07： | 1 |
| 12 | Cost effectiveness and patient satisfaction and vacuum formed retainers显示文摘 | Lisa H Heidi R Alison W | 2007 | Eur J Orthod2007，29，4： | 1 |
| 13 | Functional genomic analysis of the A UXIN/INDOLE-3-ACET1C ACID gene family members in Arabidopsis thaliana显示文摘 | Paul J O Yoko O Jos6 M A April C Chang C Joseph R E Beth H Liu A Courtney O Hong Q Alison S Yu G X Athanasios T | 2005 | Plant Cell2005，，17： | 1 |
| 14 | Apolipoprotein B gene polymorphisms,lipoproteins and coronary atherosderosis:A study of young myocardial infarction survivors and healthy population-based individuals显示文摘 | Peacock R Alison D Anders H | 1992 | Atheroselerosis1992，92，： | 1 |
| 15 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree 显示文摘 | Alison M R Golding M H Sarraf C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 16 | Microfludics for Medical Diagnostics and Biosensors 显示文摘 | Catherine R Hyewon L Alison H | 2010 | Chemical Engineering2010，66，： | 1 |
| 17 | Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice显示文摘 | BUCHER J R ALISON R H MONTGOMERY C A | 1987 | Fund Appl Toxicol1987，9，3： | 1 |
| 18 | Shear band emergence in granular materials-A numerical study 显示文摘 | ALISON O BRUCE H KLAUS R | 2007 | International Journal for Numerical and Analytical Methods in Geomechanics2007，37，3： | 1 |
| 19 | Plurpotential liver stem cells:Facultative stem cells located in the biliary tree显示文摘 | Alison M R Golding M H Sarraf C E | 1996 | Cell Prolif1996，29，： | 1 |
| 20 | Infantile Fibrosarcoma: Clinical and Histologic Responses to Cytotoxic Chemotherapy 显示文摘 | Heidi R John H Alison AB | 2009 | Pediatr Blood Cancer2009，53，1： | 1 |
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