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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Changes in soluble nitrogenous compounds, caseins and free amino acids during ripening of artisanal prato cheese: a Brazilian semi-hard cows variety显示文摘 | Gorostiza A Alexandre J C Alice T V | 2004 | Food Chemistry2004，85，3： | 1 |
| 3 | Quantitative Genetic Bases of Anthocyanin Variation in Grape (Vitis vinifera L. ssp. sativa) Berry: A Quantitative Trait Locus to Quantitative Trait Nucleotide Integrated Study显示文摘 | Fournier-Level Alexandre Le Cunff Lo?c Gomez Camila Doligez Agnès Ageorges Agnès Roux Catherine Bertrand Yves Souquet Jean-Marc Cheynier Véronique This Patrice | 2009 | Genetics2009，，3： | 1 |
| 4 | Photocatalytic Oxidation of VX Simulant 2-(butylamino)Ethanethiol显示文摘 | ALEXANDRE V V CHEN Y C PANAGIOTIS G S | 2004 | Journal of Hazardous Materials B2004，113，： | 1 |
| 5 | Lactose malabsorption and colonic fermentations alter host metabolism in rats显示文摘 | Alexandre V Even PC Larue-Achagiotis C | 2013 | Br J Nutr2013，110，4： | 1 |
| 6 | Lactose malab- sorption and colonic fermentations alter host metabolism in rats显示文摘 | Alexandre V Even PC Larue-Achaqiotis C | 2013 | Br J Nutr2013，110，4： | 1 |
| 7 | Early life blockade of 5-hydrexytryptamine 1 A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter显示文摘 | Alexandre C Popa D Fabre V | 2006 | J Neurosci2006，26，20： | 1 |
| 8 | Loop heat pipe for cooling of high-power electronic components 显示文摘 | Vasiliev L Lossouarn D Romestant C Alexandre A Bertin Y Piatsiushyk Y Romanenkov V | 2009 | International Journal of Heat and Mass Transfer2009，52，12： | 1 |
| 9 | The Role of Ultrasound in the Diagnosis of Hepatic Steatosis in Morbidly Obese Patients显示文摘 | Cláudio C Mottin MD Myriam Moretto MD Alexandre V Padoin MD Aline M Swarowsky MD Marcelo G Toneto MD Luiz Glock PhD Giuseppe Repetto MD | 2004 | Obesity Surgery2004，，5： | 1 |
| 10 | Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depres- sion-like behavior in adult knock-out mice lacking the sero- tonin transporter显示文摘 | Alexandre C Popa D Fabre V | 2006 | J Neurosci2006，26，20： | 1 |
| 11 | A gain-of- function mutation of arabidopsis CRYPTOCHROME1 promotes flowering 显示文摘 | Exner V Alexandre C Rosenfeldt G | 2010 | Plant Physiology2010，154，： | 1 |
| 12 | The Role of Ultrasound in the Diagnosis of Hepatic Steatosis in Morbidly Obese Patients显示文摘 | Cláudio C Mottin MD Myriam Moretto MD Alexandre V Padoin MD Aline M Swarowsky MD Marcelo G Toneto MD Luiz Glock PhD Giuseppe Repetto MD | 2004 | Obesity Surgery2004，，5： | 1 |
| 13 | Anti - oxidant activity of exracts from the leaves of Smallanthus显示文摘 | Katerina V Ladislav C Alexandr M | 2003 | European Joumat of Nutrition2003，42，1： | 1 |
| 14 | Anti-oxidant activity of extracts from the leaves of Smallanthus显示文摘 | Katerina V Ladislav C Alexandr M | 2003 | European Journal of Nutrition2003，42，1： | 1 |
| 15 | The Role of Ultrasound in the Diagnosis of Hepatic Steatosis in Morbidly Obese Patients显示文摘 | Cláudio C Mottin MD Myriam Moretto MD Alexandre V Padoin MD Aline M Swarowsky MD Marcelo G Toneto MD Luiz Glock PhD Giuseppe Repetto MD | 2004 | Obesity Surgery2004，，5： | 1 |
| 16 | Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin trans-porter显示文摘 | Alexandre C Popa D Fabre V | 2006 | J Neurosci2006，26，20： | 1 |
| 17 | Lymphatic system as a path underlying the spread of lung and gut injury after iniestinal isehemia/reperfusion in rats显示文摘 | GABRIELA C HELORI V D ALEXANDRE L S | 2005 | Shock2005，23，4： | 1 |
| 18 | Antioxidant activity of extracts from the leaves of Smallanthus 显示文摘 | Katerina V Ladislav C Alexandr M | 2003 | European Journal of Nutrition2003，42，1： | 1 |
| 19 | Photocatalytie oxidation of VX simulant 2-(butylamino) ethanethiol 显示文摘 | ALEXANDRE V V CHEN Y C PANAGIOTIS G S | 2004 | Journal of Hazardous Materials B2004，113，： | 1 |
| 20 | 3D porosity prediction from seismic inversion and neural networks显示文摘 | Emilson P L ALexandre C V | 2011 | Computers & Geosciences2011，37，8： | 1 |
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