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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | One decade of salivary proteomics: Currentapproaches and outstanding challenges显示文摘 | AMADO F M L FERREIRA R P VITORINAR | 2013 | ClinicalBiochemistry2013，46，6： | 1 |
| 3 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 4 | Reduction of'no-reflow'phenomenon by intraaortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study显示文摘 | AMADO L C KRAITCHMAN D L GERBER B L | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 5 | Regulation of muscle hydration upon hypo-or hyper-osmotic shocks:Differences related to invasion of the freshwater habitat by decapod crustaceans显示文摘 | FREIRE C A SOUZA-BASTOS L R AMADO E M | 2013 | J Exp Zool A Ecol Genet Physiol2013，319，6： | 1 |
| 6 | Reduction of 'no-reflow' phe- nomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study 显示文摘 | Luciano C Amado Dara L | 2004 | JACC2004，2004，： | 1 |
| 7 | Accurate and ob- jective infarct sizing bycontrast-enhanced magnetic reso- nance imaging in a canine myocardialinfaretion model 显示文摘 | Amado L Gerber B Gupta S etal | 2004 | J Am Coil Cardiol2004，44，12： | 1 |
| 8 | Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model显示文摘 | AMADO L C GERBER B L GUPTA S N | 2004 | J Am Coll Cardiol2004，44，12： | 1 |
| 9 | Reduction of 'no-reflow' phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study 显示文摘 | AMADO L C KRAITCHMAN D L GERBER B L | 2004 | J Am Coil Cardiol2004，43，7： | 1 |
| 10 | Morning rise, morning surge and daytime variability of blood pressure and cardiovascular target organ damage= a cross sectional study in 743 subjects显示文摘 | Polonia J Amado P Barbosa L | 2005 | RevPort Cardiol2005，24，1： | 1 |
| 11 | Brown algae species as biomonitors of Zn and Cd at Sepetiba Bay, Rio de Janeiro,Brazil显示文摘 | Amado F Andrade L R Karez C S | 1999 | Marine Environmental Research1999，，38： | 1 |
| 12 | A family of human beta4-galactosyltransferases:cloning and expression of two novel UDP-galactose:beta-n-acetylglycosamine beta1,4-galactosyltransferase,beta4Gal-T2 and beta4Gal-T3显示文摘 | Almeida R Amado M David L | 1997 | J Biol Chem1997，272，31： | 1 |
| 13 | Gastrointestinal complications in renal transplant recipients: MITOS study显示文摘 | Gil Vernet S Amado A Ortega F Alarcon A Bernal G Capdevila L | 2007 | Transplant Proc2007，39，： | 1 |
| 14 | Heuristic method for a mixed capacitated arc routing problem: a refuse collection application显示文摘 | MOURAO M C AMADO L | 2005 | European Journal of Operational Research2005，160，： | 1 |
| 15 | Reduction of 'no-reflow' phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study显示文摘 | LUCIANO C AMADO DARA L | 2004 | JACC2004，7，： | 1 |
| 16 | Contrast-enhancement multidetector compu ted tomography viability imaging after myocardial infarction characterization of myocyte death, microvascular obstruction and chronic scar显示文摘 | Lardo A C Cordeiro M A S Silva C Amado L C George R T Saliaris A P | 2006 | Circulation2006，113，： | 1 |
| 17 | Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction显示文摘 | Amado L C Saliaris A P Schuleri K H | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 18 | Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging显示文摘 | Azevedo C F Amado L C Kraitchman D L | 2004 | Eur Heart J2004，25，16： | 1 |
| 19 | Fe-Nx/C Electrocat- alysts Synthesized by Pyrolysis of Fe(Ⅱ)-2,3,5,6-Tetra(2- Pyridyl) Pyrazine Complex for PEM Fuel Cell Oxygen Re- duction Reaction 显示文摘 | Amado V Zhang L Wang L | 2011 | Electrochimiea Acta2011，56，13： | 1 |
| 20 | Reduction of 'no-reflow' phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study显示文摘 | AMADO L C KRAITCHMAN D L GERBER B L | 2004 | J Am Coll Cardiol2004，43，7： | 1 |
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