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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | 显示文摘 | Coleman H M Chiang K Amal R | 2005 | Chemical Engineering Journal2005，113，1： | 1 |
| 3 | A study on the removal of humic acid using advanced oxidation processes显示文摘 | Lim S M Chiang K Amal R | 2007 | Separation Science and Technology2007，42，7： | 1 |
| 4 | Novel photocatalyst: titania-coated magnetite activity and photodissolution 显示文摘 | Beydoun D Amal R Low G | 2000 | J Phys Chem B2000，104，18： | 1 |
| 5 | Implications of heat treatment on the properties of a magnetic iron oxide/titanium dioxide photo- catalyst 显示文摘 | Beydoun D Amal R | 2002 | Materials Science and Engineering2002，94，1： | 1 |
| 6 | Effect of fulvic acid adsorption on the aggregation kinetics and structure of hematite particles显示文摘 | Amal R Raper J A Waite T D | 1992 | Journal of Colloid and Interface Science1992，151，1： | 1 |
| 7 | Photocatalytic oxidation of organics in water using pure and silver-modified titanium dioxide particles显示文摘 | VAMATHEVAN V AMAL R BEYDOUN D | 2002 | J Photochem and Photobiol A2002，148，13： | 1 |
| 8 | Direct repair ( nerve gra- fting), neurotization, and end-to-side neurorrhaphy in the treatment of brachial plexus injury 显示文摘 | Haninec P S(amal F Tom(as R | 2007 | J Neurosurg2007，106，： | 1 |
| 9 | Reduced graphene oxide as a solid-state electron mediator in Z-scheme photocatalytic water splitting under visible light显示文摘 | Iwase A Ng Y H Ishiguro Y Kudo A Amal R | 2011 | Journal of the American Chemical Society2011，133，11： | 1 |
| 10 | Enteric pathogens associated with childhood diarrhea in tripoli-liby显示文摘 | Amal R John D Zaine B | 2011 | Am J Trop Med2011，84，6： | 1 |
| 11 | Implications of the structure of cementitious wastes containingPb(Ⅱ),Cd(Ⅱ),As(Ⅴ)and Cr(Ⅵ)on the leaching of metals显示文摘 | Halim C Amal R Beydoun D | 2004 | Cement and Concrete Research2004，34，7： | 1 |
| 12 | Selective synthesis of TiO2-based nanoparticles with highly active surface sites for gas-phase photocatalytic oxidation显示文摘 | Jiang Y Amal R | 2013 | Applied Catalysis B Environmental2013，，： | 1 |
| 13 | Heavy reflux PSA cycles for CO2 recovery from flue gas:Part 1 performance evaluation显示文摘 | Steven P R Amal M Armin D E | 2008 | Adsorption2008，，14： | 1 |
| 14 | Synthesis of a novelmagnetic photocatalyst by direct deposition of nano sized TiO2 crystals onto a magnetic core 显示文摘 | WATSON S BEYDOUN D AMAL R | 2002 | J Photochem Photobio A:Chem2002，148，： | 1 |
| 15 | Effects of Fe3+ and Ag+ ions on the photocatalytic degradation of sucrose in wa- ter显示文摘 | Vamathevan V Tes H Amal R | 2001 | Catal Today2001，68，13： | 1 |
| 16 | Occurrence and prevention of photodissolution at the phase junction of magnetite and titanium di- oxide显示文摘 | Beydoun D Amal R Low G | 2002 | Journal of Molecular Catalysis A : Chemical2002，180，1： | 1 |
| 17 | Synthesis of a novel magnetic photocatalyst by direct deposition of nanosized crystals onto a magnetic core 显示文摘 | Watson S Beydoun D Amal R | 2002 | Journal of Photochemistry and Photobiology A2002，148，1： | 1 |
| 18 | Synthesis of a novel magnetic photocatalyst by direct deposition of nanosized TiO2 crystals onto a magnetic core显示文摘 | Watson S Beydoun D Amal R | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，13： | 1 |
| 19 | Photocatalytic oxidation of organics in water using pure and silver-modified titanium dioxide particles 显示文摘 | Vamathevan V Amal R Beydoun D | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，1： | 1 |
| 20 | Photocatalytic oxidation of cyanide:Kinetic and mechanistic studies显示文摘 | Chiang K Amal R Tran T | 2003 | J Mol Catal A:Chem2003，，193： | 1 |
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