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| 1 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 2 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 3 | The effects of octreotide on GH receptor and IGF-I expression in the GH-deficient rat显示文摘 | Amber G R Butle A A Padmanabhan J | 1996 | J Endocrinol1996，149，2： | 1 |
| 4 | Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated eardiomyopathy显示文摘 | MUNGER M A JOHNSON B AMBER I J | 1996 | Am J Cardiol1996，77，： | 1 |
| 5 | Autosomal and Y-STR analysis of degraded DNA from the 120-year-old skeletal remains of Ezekiel Harper显示文摘 | Ambers A Gill-King H Dirkmaat D | 2014 | Forensic Sci Int Genet2014，9，： | 1 |
| 6 | Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer显示文摘 | Li Chaoyang Yu Shuiliang Nakamura Fumihiko Yin Shaoman Xu Jinghua Petrolla Amber A Singh Neena Tartakoff Alan Abbott Derek W Xin Wei Sy Man-Sun | 2009 | Journal of Clinical Investigation2009，，9： | 1 |
| 7 | Battlefield extremity injuries in Operation Iraqi Freedom显示文摘 | Amber L Dougherty A Charlene R | 2009 | Injury2009，40，7： | 1 |
| 8 | Are 4-hydroxy-2(E)-nonenal derived mereapturie acids and H-1 NMR metabonomics Potential biomarkers of ehemically induced oxidative stress in the kidney显示文摘 | Mally A Ambers A Hard GC | 2007 | Tox- icology2007，230，23： | 1 |
| 9 | Pitfalls in the diagnosis of blunt diaphragmatic injury显示文摘 | Amber A Guth H Leon P | 1995 | Am J Surg1995，170，5： | 1 |
| 10 | Are 4- hydroxy- 2(E )- nonenal derived mercapturic acids and IH-NMR metabo- nomics Potential biomarkers of chemically induced oxidative stress in the kidney 显示文摘 | Mally A Ambers A Hard GC | 2007 | Toxicology2007，230，23： | 1 |
| 11 | Artificial insemination of swine:fecundity of boar semen stored in Beltsville TS(BTS),modified modena(MM),or MR-A and inseminated on one,three and four days after collection显示文摘 | Johnson L A AMbers J G Grooten H J G | 1998 | Reproduction in Domestic Animals1998，23，2： | 1 |
| 12 | Comparing the Effects of Echoic Prompts and Echoic Prompts plus Modeled Prompts on Intraverbal Behavior显示文摘 | Valentino Amber L Shillingsburg M Alice Call Nathan A | 2012 | Journal of Applied Behavior Analysis2012，，45： | 1 |
| 13 | Hepatic Angiomyolipoma显示文摘 | Petrolla Amber A Xin Wei | 2008 | Archives of Pathology & Laboratory Medicine2008，，10： | 1 |
| 14 | Associations between body weight and personality disorders in a nationally representative sample 显示文摘 | Amber A Mather BA ( HONS) Bian J | 2005 | Am Psychosom Soc2005，70，： | 1 |
| 15 | Search for evidence of impact at the Permian -Triassic boundary in Antarctica and Australia显示文摘 | Retallack G J Seyodolali A Krull E S Holser W T Ambers C P Kyte F T | 1998 | Geology1998，26，： | 1 |
| 16 | Pseudopterosin biosynthesispathway elucidation,enzymology,and a proposed production method for anti-inflammatory metabolites from Pseudopterogorgia elisabethae显示文摘 | Amber C K Athar A Russell G K | 2003 | J Ind Microbiol Biotechnol2003，30，： | 1 |
| 17 | Anticandidal effect of Ocimum sanctum essential oils and its synergy with fluconazole and ketoconazole显示文摘 | Amber K Aijaz A Immaculata X | 2010 | Phytomedicine2010，17，12： | 1 |
| 18 | Anticandidal effect of Ocimum sanctum essential oil and its synergy with fluconazole and ketoconazole 显示文摘 | Amber K Aijaz A Immaculata X Luqman K A Nikhat M | 2010 | Phytomedieine2010，17，： | 1 |
| 19 | Pitfalls in the diagnosis of blunt diaphragmatic injury显示文摘 | Amber A Guth H Leon P | 1995 | Am J Surg1995，170，5： | 1 |
| 20 | High efficiency GaN-based LEDs and lasers on SiC显示文摘 | JOHN E AMBER A MIKE B JAYESH B KRISTIN L B DAVE E KEVIN H JAMES I MICHAEL L PHIL R DAVID S | 2004 | Journal of Crystal Growth2004，272，14： | 1 |
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