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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | The feasibility of integrating ME-TVC+MEE with azzour south power plant:Economic evaluation显示文摘 | F N Alasfour A O Bin Amer | 2006 | Desalination2006，，197： | 1 |
| 3 | The modified banzhaf value for games with coalition structure:an axiomatic characterization显示文摘 | Amer R Carreras F Gimenez J M | 2002 | Mathematical Social Sciences2002，43，： | 1 |
| 4 | Quantitative gas-solid diazotization of 3-aminopyrazolo pyri- dine derivatives and azo dye synthesis by means of solid- solid reactions显示文摘 | Kaupp G Metwally M A Amer F A | 2003 | European Journal of Organic Chemis- try2003，8，： | 1 |
| 5 | Genotoxic effect of 2,4-dichlorophenoxy ace- tic acid and its metabolite 2,4-dichlorophenol in mouse显示文摘 | Amer S M Aly F A | 2001 | Mutat Res2001，494，12： | 1 |
| 6 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiology Letters1987，46，3： | 1 |
| 7 | Thermal analysis of METVC + MEE desalination systems 显示文摘 | ALAFOUR F N DARWISH M A BIN AMER A O | 2005 | Desalination2005，174，39： | 1 |
| 8 | Thermal analysis of ME - TVC + MEE desalination systems 显示文摘 | ALASFOUR F N DARISH M A BIN AMER A O | 2005 | Desalination2005，174，： | 1 |
| 9 | Characterization of soil phosphorus by anion exchange resin adsorption and P32 equilibraton 显示文摘 | AMER F BULDIN D R BLACK C A | 1955 | Plant Soil1955，6，： | 1 |
| 10 | Mobilization of soil and fertilizer phosphate by cover crops显示文摘 | Kamh M Horst W J Amer F | 1999 | Plant and Soi11999，211，： | 1 |
| 11 | Comparison of the pharmacokinetics of lansoprazole 15- and 30-mg sachets for suspension versus intact capsules 显示文摘 | AMER F KAROL MD PAN WJ | 2004 | Clin Ther2004，26，12： | 1 |
| 12 | Therapeutic role of dietary Lactobacilli and Lactoba- cillic fermented dairy productions 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbi- ology Reviews1987，46，： | 1 |
| 13 | Industrial application of microbial lipases显示文摘 | HASAN F AMER A S HAMEED A | 2006 | Enz Microb Technol2006，39，2： | 1 |
| 14 | Nitric oxide synthase in models of focal Ischemia显示文摘 | Amer F Ted M Valina L | 1997 | Stroke1997，28，： | 1 |
| 15 | Mobilization of soil and fertilizer phosphate by cover crops显示文摘 | Kamh M Horst W J Amer F | 1999 | Plant and Soil1999，211，： | 1 |
| 16 | Characterization of soil phosphorus by anion exchange resin adsorption and 32p equilibraton显示文摘 | Amer F Buldin D R Black C A | 1955 | Plant Soil1955，6，： | 1 |
| 17 | A multiplex polymerase chain reaction method for reliable, sensitive and simultaneous detection of multiple viruses in citrus trees显示文摘 | AVIJIT R AMER F BARTHE G | 2005 | Journal of Virological Methods2005，129，： | 1 |
| 18 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiol Rev1987，46，3： | 1 |
| 19 | Development of a SYBR Green I based real-time RT-PCR assay for detection and quantification of bovine eoronavirus显示文摘 | Amer H M Almajhdi F N | 2011 | Mol Cell Probes2011，25，23： | 1 |
| 20 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiol Rev1987，46，5： | 1 |
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