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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | Simulation of hot-electron trapping and aging of nMOSFET's 显示文摘 | Patrick R Amer S | 1988 | IEEE Trans ElecDev1988，35，12： | 1 |
| 4 | Concurrent Multipath Transfer Using SCTP Multihoming over Independent End-to-End Paths显示文摘 | Iyengar J Amer P Stewart R | 2006 | IEEE/ACM Transactions on Networking2006，14，5： | 1 |
| 5 | The modified banzhaf value for games with coalition structure:an axiomatic characterization显示文摘 | Amer R Carreras F Gimenez J M | 2002 | Mathematical Social Sciences2002，43，： | 1 |
| 6 | Module identification in bipartite and directed networks 显示文摘 | GUIMERA R SALES-PARDO M AMERAL L | 2007 | Physical Review E2007，76，03： | 1 |
| 7 | Traumatic carotid-rosenthal fistula treated with Jostent Graftmaster显示文摘Traumatic injuries of the carotid artery may result in severe morbidity and mortality. The most common location of carotid artery injury is the cavernous segment, which may result in fistulous connection to the cavernous sinus and ophthalmic veins, which in turn lead to pressure symptoms in the ipsilateral orbit. Unlike the commonly reported direct traumatic carotid-cavernous fistula, we describe an unusual case of a 38-year-old man presented with a traumatic brain injury led to a fistula connection between the cavernous carotid artery and the ipsilateral basal vein of Rosenthal, with eventual drainage to the straight and transverse sinuses. The basal vein of Rosenthal is usually formed from confluence of anterior and middle cerebral veins deep in the Sylvian fissure and drain the insular cortex and the cerebral peduncles to the vein of Galen. Immediate endovascular deployment of a covered stent in the cavernous carotid artery allowed sealing the laceration site. Three months follow up showed a non-focal neurological examination and healed carotid laceration over the covered stent. | Hesham Allam R Charles Callison Daniel Scodary Aws Alawi Daniel W Hogan Amer Alshekhlee | 2014 | World Journal of Radiology2014，6，12： | 1 |
| 8 | Prospective comparative study between microsurgical and conventional testicular sperm extraction in non-obstructive azoospermia:follow-up by serial ultrasound examinations显示文摘 | Amer M Ateyah A Hany R | 2000 | Hum Reprod2000，15，： | 1 |
| 9 | Femto- second versus nanosecond laser micmmachining: comparison of induced stresses and structural changes in silicon wafers显示文摘 | AMER M S EL- ASHRY M A DOSSER L R | 2005 | Ap- plied Surface Science2005，242，： | 1 |
| 10 | Punctate inner choroidopathy 显示文摘 | Amer R Lois N | 2011 | Surv Oph- thaimol2011，56，1： | 1 |
| 11 | Molecular basis for target RNA Recognition and cleavage by human RISC显示文摘 | Ameres S Martinez J Schroeder R | 2008 | Cell2008，130，： | 1 |
| 12 | cadmium biosorption by a cadmium resistant strain of Bacillus thuringiensis:regulation and op- timization of cell surface affinity for metal cations 显示文摘 | E1 - Helow E R Sabry S A Amer R M | 2000 | Biometals2000，13，4： | 1 |
| 13 | Breeding objectives for beef cattle in Ireland显示文摘 | Amer P R | 2001 | Livestock Production Science2001，67，3： | 1 |
| 14 | Concurrent multipath trans-fer using SCTP multihoming over independent end-to-endpaths显示文摘 | Iyengar J R Amer P D Stewart R | 2006 | IEEE/ACM Transactions on Networking2006，14，5： | 1 |
| 15 | Detection of genetic diversity in Libyan wheat genotypesusing wheat microsatellite markers显示文摘 | Ibrahim M. Ben Amer Andreas B?rner Marion S. R?der | 2001 | Genetic Resources and Crop Evolution2001，，6： | 1 |
| 16 | Molecular basis for target RNA recognition and cleavage by human RISC 显示文摘 | Ameres SL Martinez J Schroeder R | 2007 | Cell2007，130，： | 1 |
| 17 | Punctate inner choroidopathy 显示文摘 | Amer R Lois N | 2011 | Surv Oph- thalmo12011，56，1： | 1 |
| 18 | Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006) 显示文摘 | Amer M Oayyum R | 2012 | T Am J Cardiol2012，109，1： | 1 |
| 19 | Characterization of soil phosphorus by anion exchange resin adsorption and P32 equilibraton 显示文摘 | AMER F BULDIN D R BLACK C A | 1955 | Plant Soil1955，6，： | 1 |
| 20 | Introduction of compressive residual stresses in Ti-6Al-4Al simulated airfoils via laser shock processing 显示文摘 | SHEPARD M J SMITH P R AMER M S | 2001 | Journal of Materials Engineering and Performance2001，10，6： | 1 |
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